National University of Singapore

Associations of carboxypeptidase A1 and gamma-glutamyltransferase 1 genotypes with refractory functional dyspepsia: a potential link to pancreatic pathophysiology and refractory dyspepsia

Background and Aims This study aimed to investigate the associations between SNPs in CPA1, GGT1, and SPINK1 genes and the clinical characteristics of refractory FD including clinical symptoms, pancreatic enzyme abnormalities, and exocrine pancreatic function.Methods 97 Patients w...

A tutorial on fitting flexible meta-analytic models with structural equation modeling in R

Abstract There are various statistical models with different features and assumptions in meta-analysis. Popular models include the fixed-effect (or common effect), random-effects, and mixed-effects models. Apart from these models, several alternative models, such as the multiplic...

Correlated insulator Moiré bolometer

Light incident on an insulator is generally not expected to turn it into a metal without invoking intense ultrafast excitation that leads to transient structural transitions. Here we show that magic-angle twisted bilayer graphene tuned to half filling of the moiré band provides a...

Spin-quenching cobalt center for efficient ammonia synthesis derived from oxide mixology

The spin polarization plays a critical role in heterogeneous catalysis by influencing the properties of active sites and thereby altering catalytic performance. However, precise construction of active sites with well-tuned spin states remains challenging. Here we demonstrate to m...

Multimodal Bioinspired Self‐Healing Composites Enabling Durable and High‐Efficiency Wearable Perovskite Light‐Emitting Diodes

ABSTRACT Wearable and flexible optoelectronic devices are rapidly advancing toward human‐interactive applications. However, their operational lifespan is often limited by mechanical damage, interface delamination, and environmental influences. Existing encapsulation methods provi...

Artificial intelligence-enabled insights into dietary modifications driving the progression from metabolic dysfunction-associated steatotic liver disease to hepatocellular carcinoma

Dietary patterns represent a major modifiable risk factor contributing to metabolic dysfunction-associated steatotic liver disease (MASLD), which can lead to insulin resistance, inflammation, gut dysfunction and hepatic steatosis. Diet-induced animal models have become essential...

Phenotypes of painful TMDs and bruxism based on clinical, psychosocial and somatosensory features: a cluster analysis

To identify pain phenotypes among individuals with bruxism and painful temporomandibular disorders (TMD) by integrating clinical, psychosocial, and somatosensory variables. This cross-sectional observational study included 54 adults who self-reported and were clinically assessed...

Age-Associated Patterns of Cardiovascular Risk and Disease Phenotypes Across Diverse Care Settings: The GLOB-cAGE Consortium

Reported prevalence of cardiovascular disease (CVD) risk factors and phenotypes varies widely. In multi-cohort analyses, such variation reflects population risk, care setting, and data capture. We harmonized baseline data from four analytic cohorts (N=54,188, aged ≥50 years) in f...

Characterisation of liver disease using quantitative MRI: report of the imaging arm of the ELEGANCE study

Evolving disease aetiology and rising prevalence of chronic liver disease are driving an increase in hepatocellular carcinoma (HCC). Non-contrast quantitative MRI (qMRI) has shown promising capability for characterising liver health and risk of liver related outcomes, but has not...

High‐Performance Self‐Assembled Amphiphilic Block Copolymer Thermoelectric Ionogel for Low‐Humidity Heat Harvesting

ABSTRACT Ionic thermoelectric (i‐TE) materials have attracted considerable interest due to their abilities to generate high thermovoltage for low‐grade waste heat harvesting. However, challenge still remains to develop high‐performance i‐TE materials, especially at relative low h...

Tea and cognitive health in aging: Current evidence and future directions

The health benefits of tea drinking have been extensively studied, and in the past 20 years, there has been increasing interest in the role of tea drinking in promoting cognitive health among older adults. This review aims to analyze existing evidence on the benefits of tea drink...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Genomic, transcriptomic, and molecular predictors of response to neoadjuvant therapy in locally advanced rectal cancer: a narrative review

Total neoadjuvant therapy (TNT) has emerged as a key treatment paradigm for locally advanced rectal cancer, reducing distant metastasis rates and facilitating organ preservation in selected patients. However, treatment response remains heterogeneous, highlighting the need for bio...

Vulnerable groups’ engagement with interventions to mitigate the health impacts of exposure to extreme temperature events: a qualitative systematic review

Abstract Extreme temperature events are becoming more frequent. Such events are defined as unusually hot weather persisting for at least two consecutive days (heatwave) or unusually cold weather persisting for at least two consecutive days (cold wave) within the context of geogra...

Nitro Reduction‐Based RNA Control and Ultrafast Release

RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post-synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straightforward...

Nitro Reduction‐Based RNA Control and Ultrafast Release

ABSTRACT RNA protection and controlled release are critical for both fundamental research and therapeutic applications, yet the development of simple, efficient, and reversible post‐synthetic RNA modification strategies remains a significant challenge. Here, we introduce a straig...

Risk of new‐incident mental health diagnoses following SARS ‐ CoV ‐2 infection amongst children and young adults in Singapore: a retrospective cohort study

Background Mental‐health‐disorders in children/young adults increased post‐pandemic; however, the absence of linkage to COVID‐19 registries made direct attribution of psychological sequelae to acute infection challenging. Methods Healthcare‐claims databases in Singapore were util...

Passive sampling reveals composition of airborne bacteria and fungi across five East African cities

Airborne microbes significantly influence environmental processes and human exposure, yet they remain poorly characterized in Africa. This study presents a regional survey of airborne bacterial and fungal communities across 10 sites in five East African countries: Burundi, the De...

Targeting FibroblastActivation Protein for PrecisionMedicine

Conspectus The advancement of precision medicine depends critically on well-defined molecular targets. Pathologically activated fibroblasts drive disease progression in cancer, fibrosis and chronic inflammation through sustained inflammation, extracellular matrix remodeling and p...

A Multi-Modal Pre-training Framework-Driven Active Learning System for Enhanced Protein Evolution of Cs CE

Abstract Protein language models have shown strong potential in modeling fitness landscapes for directed evolution; however, their predictive accuracy and generalization to unexplored sequence space remain limited under few-shot learning conditions. Here, we present MmALS (Multi-...