Nanjing University

APE1-Responsive Adaptive DNA Nanomachines for Prolonged Intracellular Bioanalysis and Sustained Gene Silencing

Abstract Rapid cellular clearance severely restricts the effective analytical and functional windows of intracellular probes. Herein, we developed an endogenous enzyme-driven adaptive DNA nanomachine (TRZL) that synchronizes target recognition with in situ morphological transform...

The Effect of Smile Cues on Food Calorie Perception: The Moderating Role of Dietary Restraint

ABSTRACT Consumers are becoming increasingly attentive to healthy eating and the caloric content of their food. However, when judging a food's calories, they often lack sufficient knowledge or objective information and therefore rely on marketplace cues to make subjective evaluat...

Who will replace their phones? An explainable machine learning approach using large-scale telecom behavioral data

Purpose Rapid technological innovation has accelerated the diffusion of mobile phones and communication networks, making phone replacement an important consumer behavior in the telecommunications market. However, limited research has examined the determinants of phone replacement...

Multimodal Transformer Integrating CT and Pathology for Postoperative Risk Stratification in Stage I Non–Small Cell Lung Cancer

A biologically interpretable multimodal artificial intelligence framework outperformed guideline-based postoperative risk stratification for stage I non–small cell lung cancer and identified patients who would benefit from adjuvant therapy.

The mechanosensitive channel TMEM63B contributes to noxious heat sensation in the dorsal root ganglia

In mammals, heat sensation is primarily mediated by thermosensitive channels, particularly transient receptor potential (TRP) channels, in dorsal root ganglion (DRG) neurons. However, whether additional channels contribute to noxious heat detection remains unclear. Here, we inves...

Net carbon emission accounts, drivers, and mitigation measures in China, 1980–2020

Mitigating net CO 2 emissions under socioeconomic development and climate variability is essential for climate action and sustainable development goals. Here, focusing on anthropogenic emissions and terrestrial ecosystem sinks, we construct a national-scale account of China's net...

Condensation Sink Efficiency of Atmospheric Particles Regulated by Their Chemical Compositions and Hygroscopicity

Abstract Condensation sink (CS) from atmospheric pre-existing particles is a crucial limiting factor for the occurrence of new particle formation (NPF). However, intense NPF events occur frequently in polluted urban areas despite high CS levels. Here, to address this discrepancy,...

Electronic tuning of dynamic imine bonds enables programmable pore gating in metal–organic frameworks

Metal–organic frameworks (MOFs) are promising host matrices for molecular encapsulation, yet their application is often limited by fixed pore apertures that exclude guest molecules larger than the pore openings. Herein, we overcome this limitation by electronic tuning of dynamic...

Visible-Light-Driven C–H Arylation of Aminoquinones with Diaryliodonium Salts

Abstract A visible-light-driven C–H arylation of 2-amino-1,4-naphthoquinones with diaryliodonium salts has been developed using 10-phenylphenothiazine (PTH) as a photocatalyst. Mechanistic studies reveal that aminoquinone serves both as the substrate and as an electron shuttle in...

Pd-Catalyzed Freon-Enabled Aminocarbonylation of Aryl Iodides

Abstract A palladium-catalyzed Freon-to-carbonyl transfer strategy has been developed for the CO-free aminocarbonylation of aryl and heteroaryl iodides with amines. Using chlorodifluoromethane (Freon-22) as both a difluorocarbene precursor and a carbonyl source, this protocol ena...

High‐Speed Electrically Driven Liquid‐Crystal Compact Optical Skyrmion Encoder

ABSTRACT Optical skyrmions are topologically nontrivial polarization textures with intrinsic robustness under external perturbations, making them promising carriers for disturbance‐resistant optical information transmission. However, existing optical skyrmion generation schemes m...

Single-Molecule Studies Reveal That Water Starts to Protect Proteins Even at the ppm Level

Abstract A consensus established by extensive thermodynamic and structural studies of proteins and DNA is that water acts as an indispensable structural cofactor rather than a passive solvent for biomolecules. Nevertheless, it remains unclear whether trace water still exerts a st...

From office to living room: linking AI awareness and career sustainability from a work–family boundary perspective

Purpose Drawing upon work–family boundary theory and the significance of employees career sustainability amid widespread artificial intelligence (AI) adoption, this study examines the impact of AI awareness on two indicators of career sustainability (i.e. well-being and productiv...

Nanopore Identification of Nicotine in Cigarette Tobacco and Its Smoke

Abstract Smoking poses a severe threat to global public health. Nicotine, as the predominant addictive constituent existing in both tobacco matrices and inhaled smoke, requires direct and reliable detection for health risk evaluation and tobacco quality control. In this work, we...

Architecting Anisotropic Force‐Responsive Bidirectional High‐Contrast Three‐Color Fluorescence Switches via Effective Molecular Modulation for High‐Security Information Storage

ABSTRACT Although bidirectional three‐color fluorescent molecular switches triggered by anisotropic force are promising for enhancing the security of information storage, the engineering and development of such force‐responsive smart emissive materials face significant challenges...

A renal cyst-clear cell renal cell carcinoma comorbidity analysis identifies a FOXM1-positive epithelial COL6A1-CD44 axis that remodels fibroblasts

Background Renal cystic conditions are heterogeneous. We used a broad renal cyst-associated disease-gene framework to identify molecular programs shared with clear cell renal cell carcinoma (ccRCC), without modeling a specific cystic disorder or direct cyst-to-cancer progression....

Experimental Signature of Transient Symmetry Breaking in a Cavity Dirty-Limit Superconductor

Abstract Transient states of matter far from equilibrium may exhibit physical properties beyond those allowed by the equilibrium-state crystalline symmetries. We explore ultrafast and direct electronic excitations of transient states in a dirty-limit superconductor with time-reso...

Calcium-Associated Cellular Integrity and MAPK/cAMP Signaling Are Associated with Low-Temperature Acclimation in Schizophyllum commune 20R-7-F01

Temperature is a critical environmental factor affecting fungal growth, morphogenesis, and reproduction. Schizophyllum commune, a model basidiomycete fungus, exhibits remarkable developmental plasticity under environmental fluctuations; however, the mechanisms underlying its adap...

Manganese-modified biochar enhances white-rot fungi-mediated lignocellulose humification: insights from molecular transformation and multi-omics analyses

Humic substance formation is essential for soil health, yet natural humification is slow, and synthetic production is often inefficient. White-rot fungi (WRF)-mediated lignocellulose humification shows potential but is limited by slow substrate degradation. Given the high biocata...

Role of desolvation on biomolecular liquid–liquid phase separation

Abstract Biomolecular condensates play essential roles in cellular organization and are implicated in diverse pathological processes. Their formation is driven by liquid-liquid phase separation (LLPS), a process that requires coordinated multistep desolvation of biomolecular chai...