Nanjing University of Chinese Medicine

Early gastric carcinoma with lymphoid stroma associated with a low risk of lymph node metastasis and favorable prognosis: a multicenter study in a Chinese population

Abstract Objective Gastric carcinoma with lymphoid stroma is a rare subtype of gastric carcinoma. The clinicopathological features and prognosis of early gastric carcinoma with lymphoid stroma (EGCLS) remain elusive, especially in Chinese populations. Methods In this study, we in...

Joint association of estimated glucose disposal rate and physical activity with cardiovascular disease incidence in patients with cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study based on the CHARLS database

Cardiovascular-kidney-metabolic (CKM) syndrome is a new concept proposed by the American Heart Association (AHA) that emphasizes the complex relationship between kidney disease, heart disease and metabolic factors. Many studies have shown that insulin resistance (IR) in CKM syndr...

Latent profiles of perceived digital convenience and their associations with depressive symptoms among Chinese empty-nest older adults: evidence from the 2023 CLASS

Digital technology is increasingly discussed as a potential resource for supporting mental health in later life, yet empirical findings remain mixed. Prior studies have largely relied on variable-centered approaches that may obscure how perceived convenience of digital activities...

Occlusion-Robust Cattle Pose Estimation for Precision Livestock Monitoring Using Hierarchical Locality Refinement

Accurate cattle pose estimation is important for precision livestock farming because body landmarks can provide quantitative visual inputs for potential health monitoring, behavior analysis, lameness assessment, and welfare evaluation. This study focuses on keypoint-localization...

The Effects of Acupuncture at Shuigou (GV26) on Patients With Disorders of Consciousness: An EEG Nonlinear Dynamics Analysis

Background Disorders of consciousness (DOC) lack objective biomarkers. We evaluated the immediate cortical effects of acupuncture at Shuigou (GV26) in DOC patients using nonlinear EEG parameters: approximate entropy (ApEn), Lempel–Ziv complexity (LZC), correlation dimension ( D 2...

Remote electroacupuncture conditioning protects the heart via fine-tuning the dual role of the SDF-1α/CXCR4 axis in myocardial ischemia–reperfusion injury

BACKGROUND: Remote electroacupuncture (EA) conditioning on forearm protects against myocardial ischemia-reperfusion injury (MIRI). However, the cardioprotective mechanisms of RIC have not been fully elucidated. This study aimed to investigate whether EA could balance the pro-surv...

Anticancer effects of an XPO1 inhibitor (selinexor) with sotorasib following omeprazole preconditioning in KRAS G12C-mutant non-small cell lung cancer cells in vitro and in a mouse tumor xenograft

BACKGROUND: KRAS G12C-mutant advanced non-small cell lung cancer (NSCLC) is currently treated with KRAS G12C covalent inhibitors, such as sotorasib, or RAS (ON) G12-selective inhibitors; however, response rates and progression-free survival remain limited, with recurrence occurri...

Fructose directly remodels the translocase of the outer membrane to impair oxidative phosphorylation in podocytes

Excessive dietary fructose consumption contributes to the rapidly increasing prevalence of obesity, metabolic syndrome, and chronic kidney disease worldwide, and accumulating preclinical evidence has confirmed that excess fructose exposure provokes severe mitochondrial dysfunctio...

Has hydrological alteration driven ecosystem service risks in large floodplain lakes? A novel framework for spatiotemporal assessment and hydrological thresholds identification

Study region Poyang Lake, China’s largest freshwater lake, is a critical ecological hub. Study focus Hydrological alteration strongly affects floodplain ecosystem services (ES), yet their spatiotemporal risks and hydrological controls remain poorly understood. We developed an int...

Endothelial cell-microglia crosstalk mediates heart failure-associated synaptic loss and cognitive impairment in male mice

Cognitive impairment affects 30%–80% of patients with heart failure, yet the mechanisms beyond reduced brain blood flow remain poorly defined. Here we show that circulating factors released during heart failure trigger senescence of brain blood-vessel endothelial cells, which in...

Temporal Profiles and Clinical Associations of Lipoprotein and Apolipoprotein Profiles in Critically Ill Patients with Persistent Inflammation, Immunosuppression, and Catabolism Syndrome (PIICS): A Retrospective Cohort Study

Persistent inflammation, immunosuppression, and catabolism syndrome (PIICS) is a severe complication in critically ill patients, accompanied by profound disturbances in lipid metabolism. However, the sequential changes in these lipoproteins and apolipoproteins and their associati...

Active ingredients and molecular targets of Tripterygium wilfordii against colorectal cancer: network pharmacology, molecular docking, molecular dynamics simulations and in vitro evaluation

Colorectal cancer (CRC) is one of the common malignant tumors of the gastrointestinal tract, encompassing both colon cancer and rectal cancer. This study explores the therapeutic potential of T. wilfordii in CRC through network pharmacology, molecular docking, and in vitro experi...

A ParallelogramTetranickel Complex with a Short Ni–NiBond Supported by a Pentadentate N-Ligand

Abstract Metal–metal bonded complexes feature unique intermetallic synergy enabling small-molecule activation and organic transformations. Using a pentadentate N-ligand, a dinickel paddlewheel complex is obtained from NiCl2, while a tetranickel complex with a short Ni–Ni bond in...

Ginsenoside Rg1Attenuates Neuroinflammation in Parkinson’sDisease Models via Concomitant Modulation of Canonical and NoncanonicalWnt Pathways in Microglial M1/M2 Polarization

Abstract Microglial-mediated neuroinflammation is a core driver of brain disorders. Thus, modulating microglial activity is a critical therapeutic goal. In this study, we explored how Ginsenoside Rg1 (Rg1) protects against the inflammation seen in Parkinson’s disease (PD). Our ex...

Targeting breast cancer stem cells by restoring RBM38 function: mechanism and protein delivery therapy

Breast cancer stemness drives tumor progression and therapy resistance, yet the underlying mechanisms remain poorly understood. In this study, we observed that RBM38 expression gradually decreases during breast cancer progression in MMTV - PyMT transgenic mice. Using a model with...

From multifaceted mechanisms to targeted strategies: advances in PANoptosomes as regulatory hubs of PANoptosis in cancer

Programmed cell death (PCD) is a fundamental barrier to tumorigenesis, but cancer cells often evolve ways to evade single-mode death pathways. PANoptosis is a newly recognized form of PCD that integrates features of pyroptosis, apoptosis, and necroptosis. PANoptosomes organize th...

Spatial Partitioning of Phenylpropanoid- and Auxin-Related Metabolites in Sparganium stoloniferum Tubers

Phenolic acids and flavonoids are major bioactive constituents of Sparganium stoloniferum tubers (SL), yet their spatial organization within this medicinal organ remains insufficiently characterized, limiting understanding of how anatomical structure relates to metabolite distrib...

BCL9 inhibition promotes fibroblast lipogenesis by regulating macrophage–fibroblast interactions to attenuate pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal interstitial lung disease with an urgent need for novel therapeutic strategies. M2 macrophage-derived TGF-β1 promotes fibroblast myogenesis, contributing to IPF pathogenesis. Targeting macrophage polarization and fibr...

Assessing Dazhu Hongjingtian: Protection Against Acute Hypoxic Organ Damage and Analysis of Its Main Pharmaceutical Components

ABSTRACT Dazhu Hongjingtian (DZ), a traditional Tibetan medicine used for altitude sickness and blood stasis syndrome, currently lacks comprehensive pharmacological and quality control data. This study evaluated its antihypoxic effects in mice and established an HPLC‐MS/MS method...

Macrophage senescence and senescence-like states in senile osteoporosis: cellular cross-talk and therapeutic perspectives

Senile osteoporosis (SOP) is an age-related metabolic bone disease characterized by reduced bone quality and increased fracture risk, closely associated with immune senescence. Among immune components in the bone marrow niche, macrophages undergo age-associated phenotypic and fun...