Medical University of Vienna

Rebuilding a protective allele with ADAR site-directed RNA editing

De Chiara F, Coll-de la Rubia E, de Bruijn P et al. ADAR RNA editing for cardiovascular disease: Targeting B4GALT1 to modulate lipid metabolism through reduced galactosyltransferase activity. Molecular Therapy Nucleic Acids. 2026;37(3):103001. https://doi.org/10.1016/j.omtn.2026....

Functional pathway phenotyping reveals increased LRRK2 activity beyond recognised genetic causes of Parkinson’s disease

Abstract Pathogenic LRRK2 variants cause Parkinson’s disease (PD) through increased kinase activity, with VPS35 p.D620N and other emerging genetic factors also increasing LRRK2 signalling. Findings in idiopathic PD also suggest broader LRRK2 pathway involvement. As LRRK2-targeted...

No detectable association of APOE ε4 with spatial navigation and broader cognition in healthy young adults

Abstract Alzheimer’s disease (AD) causes progressive memory loss and disorientation. It is preceded by a prolonged preclinical phase marked by pathological changes in medial temporal lobe regions involved in spatial navigation. Spatial navigation tasks have been proposed for earl...

Re‐evaluating impaired consciousness in temporal lobe epilepsy: The role of language dominance and network reorganization

Abstract Objective Temporal lobe epilepsy (TLE) frequently affects clinically‐classified ictal consciousness, which the 2025 International League Against Epilepsy (ILAE) classification operationalizes through clinical assessment of awareness and responsiveness. It remains uncerta...

Optical microscopy predictions of focal recurrence in glioblastoma

A hallmark of glioblastoma (GBM) is disease recurrence that occurs in all patients despite resection, radiation, and chemotherapy. A critical challenge in GBM treatment is the management of recurrent disease for which no standard of care exists. Predicting the location of GBM rec...

Fibrinoid-associated neutrophils promote invasive placentation and neutrophil reprogramming at the maternal-fetal interface

Successful early pregnancy depends on coordinated interactions between the placenta and maternal immune cells, but the mechanisms underlying this interplay remain incompletely understood. Placenta-derived extravillous trophoblasts (EVTs) invade the decidua basalis and remodel mat...

Atlas of cell types and regulatory elements underlying human facial diversity

Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we create...

Long-term survival after allogeneic stem cell transplantation in patients with acute myeloid leukemia

Abstract Allogeneic hematopoietic cell transplantation (HCT) is the only curative treatment for patients with higher-risk acute myeloid leukemia (AML), but survival is limited by recurrent malignancy and complications such as organ toxicity and infections. This study evaluated ov...

Structural validity and measurement invariance of the WHO-5 Well-Being Index among young adolescents in a family-focused prevention context in Southeastern Europe

Abstract Background The World Health Organization Five Well-Being Index (WHO-5) is a widely used, open-access measure of subjective well-being. However, evidence on its psychometric properties among young adolescents participating in preventive interventions in low- and middle-in...

Approaches and challenges in the development and production of films related to suicide: qualitative interview study of filmmakers’ perspectives

Abstract Background The portrayal of suicide is a common theme in the film industry, and the accurate and safe portrayal is a public health priority. However, insight into how film crews experience the development and production of a short film about suicide is lacking. In a coll...

Real-World Experience With the Extravascular Implantable Cardioverter Defibrillator Through 1 Year: The Enlighten Post Approval Registry Study

BACKGROUND: The extravascular implantable cardioverter defibrillator (EV-ICD) was developed to provide defibrillation and antitachycardia pacing therapy without the need for intravascular lead placement. Premarket clinical trials reported EV-ICD safety and efficacy through 3 year...

Mild autonomous cortisol secretion (MACS) is associated with increased mortality in patients with adrenal adenomas only in the presence of type 2 diabetes: a retrospective cohort study

Abstract Background Hypercortisolism and type 2 diabetes mellitus (T2D) independently contribute to an increased burden of cardiometabolic morbidity and mortality. However, data on the interaction of hypercortisolism and T2D are scarce—thus, we aimed to assess the cortisol-associ...

Mental health and substance use in Europe: initial steps towards a common European approach

BACKGROUND AND AIMS: Comorbid substance use and other mental health disorders contribute to more than one million years lived with disability in Europe according to the Global Burden of Disease study. They require a comprehensive approach, yet, in Europe, there is considerable va...

Memory of the renin-angiotensin system following heart transplantation or implantation of a left ventricular assist device

Abstract Background Renin-angiotensin system (RAS) inhibitors, while not routinely recommended after heart transplantation (HT), are advised in left ventricular assist device (LVAD) recipients to promote reverse remodeling and support myocardial recovery. Whether restoring hemody...

Thermodynamics of driven systems with explicitly broken detailed balance

Abstract In systems with detailed balance, the stationary distribution and the equilibrium distribution are identical, creating a clear connection between energetic and entropic quantities. Many driven systems violate detailed balance and still pose a challenge for a consistent t...

Lived experiences of women undergoing emergency hysterectomy following uterine rupture in Ethiopia: a descriptive phenomenological study

Uterine rupture is a life-threatening obstetric emergency that often requires immediate surgical intervention to prevent maternal death and severe morbidity. In some cases, hysterectomy is performed as a life-saving procedure. Although hysterectomy can save women’s lives, it may...

Classifying adult-type diffuse glioma using 7T magnetic resonance spectroscopic imaging

Abstract Objectives Established clinical MR imaging offers limited accuracy for the precise classification of adult-type diffuse glioma. The purpose of this study was to identify robust 7T MRSI metabolic markers that distinguish glioblastoma, IDH-wildtype (GBM); astrocytoma, IDH-...

Multiligament Injury, Medial Meniscus Tear, Hyperextension‐Type Bone Bruise Pattern, and Younger Age Predict Magnetic Resonance Imaging‐Defined Tear Location in Acute, Complete Posterior Cruciate Ligament Injuries

Purpose To characterize the epidemiology of posterior cruciate ligament (PCL) tear locations and identify clinicodemographic and injury‐related predictors. Methods This retrospective cohort study at a single institution included patients with acute, complete PCL injuries between...

Patient-reported outcomes after surgical treatment of spontaneous intracranial hypotension: a cross-sectional study

Abstract Background Spontaneous intracranial hypotension (SIH) can cause substantial functional and psychosocial impairment, but patient-reported outcomes after surgical treatment remain incompletely understood. This study aimed to describe postoperative symptom burden, functiona...

Dental Procedure-Related Emphysema: A Scoping Review of Clinical Presentation, Anatomical Distribution, Management, and Outcomes

Background/Objectives: Dental procedure-related emphysema is an infrequently reported complication of dental care that may extend from superficial facial tissues into deep cervical, mediastinal, orbital, thoracic, intracranial, or vascular compartments. This revised scoping revie...