McMaster University

P1.173. Endoscopic Resection Versus Esophagectomy for T1b Esophageal Cancer – a Systematic Review and Meta-Analysis

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophagectomy remains the standard of care for most esophageal cancer. Newer evidence supports the use of endoscopic resection (ER) including endoscopic mucosal resection (EMR) or endoscopic subm...

Congenital Tuberculosis in a 2-Week-Old Neonate With an Asymptomatic Mother

Congenital tuberculosis (TB) is a rare condition, and diagnosis is challenging due to its nonspecific clinical presentation and rarity. It has a very high case-fatality rate (estimated at 30%–50%). We report the case of a 2-week-old male neonate, born from an uncomplicated diamni...

Putting Globus Into Context: Prevalence, Characteristics, and Overlap With Other Disorders of Gut‐Brain Interaction

OBJECTIVE: Globus is characterized by the sensation of a lump in the throat without dysphagia or underlying structural abnormality or major motility disorder. Reported prevalences vary considerably across studies. Globus has been linked to both heartburn and affective disorders....

Harnessing Diversity: Majority‐Group Acculturation Predicts Creativity and Flourishing Over Time

ABSTRACT Creativity and flourishing are core aims of higher education (HE) institutions and government initiatives globally. Large‐scale projects have linked creativity and flourishing with cultural diversity, yet their associations with majority‐group acculturation (i.e., how me...

Interrogating the Effects of Technologies of Pregnancy Surveillance on Queer, Trans and Nonbinary Midwifery Service‐Users

Queer, transgender and nonbinary (QTNB) people access midwifery services, yet little is known about their experiences of midwifery care. Our qualitative study used critical narrative inquiry to examine how QTNB midwifery service-users in Ontario, Canada, experience cisheteronorma...

Unlocking air cargo demand: A novel predictive model selection framework based on data characteristics

Air cargo transportation plays a key role in global trade, especially for time-sensitive and high-value products. Accurate prediction of air cargo demand is essential for informed decision-making on infrastructure planning, capacity management, and resource allocation across the...

Antegrade versus retrograde ureteroscopy for large proximal ureteric stones: a meta‐analysis

OBJECTIVES: To perform a meta-analysis comparing the outcome of antegrade versus retrograde ureteroscopy for the management of large proximal ureteric stones. METHODS: A systematic review and meta-analysis of randomized controlled trials was conducted in line with the Preferred R...

Consensus based expert recommendations for management and prevention of RSV infections in older adults in emerging market countries: results from an expert panel structured survey

BACKGROUND: Respiratory syncytial virus (RSV) can cause serious disease in older adults (OAs), particularly those with comorbidities. It is a leading cause of acute respiratory illness and lower respiratory tract infections in adults ≥60 years. Its impact on morbidity, mortality,...

A bibliometric analysis of preprints in traditional, complementary, and integrative medicine research

Abstract Background Traditional, complementary, and integrative medicine (TCIM) encompasses a wide range of healthcare practices and is of growing global interest. Preprints, scientific manuscripts posted prior to formal peer review, offer opportunities to address challenges in T...

Inadequate Reporting of Harms in RCTs of Chinese Herbal Medicine Formulas: A Systematic Survey of Leading Medical Journals

ABSTRACT Objective To evaluate harms reporting practices in placebo‐controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English‐language and Tier‐1 Chinese journals. Methods This systematic survey evaluated harms rep...

Statistical methods, outcome structures, and research designs in hybrid type II effectiveness-implementation studies: protocol for a scoping review

<ns5:p>Background Hybrid type II effectiveness-implementation studies evaluate health intervention and implementation strategy effectiveness simultaneously. While the emphasis on each “side” varies within hybrid type II studies, the focus of this review is those that attempt a mo...

Bullying victimization, language proficiency, and school belonging among Syrian refugee early adolescents in Canada: A cross‐lagged and random‐intercept cross‐lagged panel study

Abstract Refugee children's school adjustment is often associated with host country language proficiency, peer victimization, and school belonging, but longitudinal associations among these constructs may reflect both stable child differences and time‐varying school‐experience pr...

Resilience and Protective Factors for Mental Health among Indigenous Youth in Canada: A Scoping Review

Abstract Indigenous youth’s inherent strength and resilience play a vital role in their well-being and mental health. Protective factors, closely linked to resilience, spanning individual, family, and community levels reinforce positive mental health outcomes. The purpose of the...

The Association Between Intranasal Steroids and Length of Stay in Children With Orbital Infections

OBJECTIVE: Little is known about the use of intranasal agents in the management of orbital infections in children. This study aims to describe intranasal corticosteroid use in children hospitalized with orbital infections and to determine whether an association exists between int...

AI-driven design and electrothermal actuation of 4D-Printed carbon fiber-reinforced composites

This study presents a data-driven framework for the design, prediction, and optimization of electrothermally actuated composite structures based on continuous carbon-fiber reinforced shape memory polymers (CCF-SMPs). A Multiphysics model was developed and calibrated against exper...

MRI‐based deep learning models match or surpass physician performance for early detection and staging of avascular necrosis of the femoral head: A systematic review

PURPOSE: Efficient and reliable magnetic resonance imaging (MRI)-based diagnosis of early avascular necrosis of the femoral head (AVNFH) is essential for guiding treatment but remains challenging due to variability in clinician experience. Deep learning (DL) models offer a promis...

Distribution-sensitive predictors of gait speed in adults aged 45–85 years in the CLSA

Gait speed, known as the ‘sixth vital sign’ is an indicator of functional health and aging. Identifying drivers of midlife gait changes is critical for timely intervention, yet most evidence focuses on older adults and overlooks non-linear, heterogeneous effects. We applied machi...

Aflibercept 8 mg in neovascular age-related macular degeneration and diabetic macular oedema: Translating clinical trials into clinical practice

Abstract Provide expert-informed guidance on the integration of aflibercept 8 mg into routine clinical care for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular oedema (DMO), based on clinical trial and real-world evidence. Sixteen retina spe...

Toward more accurate natural orbital functional approximations: Including 4-index cumulant contributions

Accurate modeling of bond breaking remains a central challenge for reduced density matrix functional theory (RDMFT). Although some modern functionals can yield reasonably accurate dissociation energies, they often fail to reproduce key properties of the dissociated fragments, suc...

CMV-specific clonal expansion in human Th1 and GZMK⁺ CD8⁺ T cells

Cytomegalovirus (CMV) is a common herpesvirus that establishes lifelong latency and becomes increasingly prevalent with age. To systematically delineate CMV-associated immune remodeling at single-cell resolution, we analysed six human cohorts (including two newly established coho...