McMaster University

Protocol for the isolation, enrichment, and culture of murine adipose progenitor cells

We present a protocol for isolating and culturing murine adipose progenitor cells (APCs) from adipose tissue. We describe steps for tissue dissection, unit-normalized enzymatic digestion, stromal vascular fraction (SVF) isolation, APC enrichment, and cell culture. We then detail...

Ultraprocessed Food Intake and Adiposity, Vascular Brain Injury, and Cognition in Middle-Aged Adults

Importance Ultraprocessed foods (UPFs) account for a substantial and increasing proportion of dietary intake in Canada. Although UPFs are consistently associated with adiposity and cardiometabolic disease, their associations with subclinical vascular brain injury (VBI) and cognit...

Screening for Early Endometriosis Detection (SEED): Co-development of a Symptom-Based Screening Measure for Canadian Young Adults in Primary Care

Background Many Canadians experience prolonged pain, uncertainty, and stigma before receiving an endometriosis diagnosis, with delays averaging 11 years from symptom onset. Endometriosis, defined by the presence of endometrial-like tissue outside the uterine cavity, impacts 10% o...

Spontaneous Nanopatterning and Strain Relaxation in SiGe Layers Grown by Oxidative Solid‐Phase Epitaxy

ABSTRACT The wafer‐scale monolithic integration of III‐V materials on Si would lead to revolutionary optoelectronic hardware for data, computing, and other applications. However, heteroepitaxy of III‐Vs on Si requires overcoming the large lattice and thermal mismatches between th...

Interferon-λ inhibits immunopathology and boosts T cell–mediated immunity in a mouse model of mucosal viral infection

Interferon lambda (IFN-λ) has emerged as a critical inducer of immune regulation in addition to its mucosal antiviral properties. However, the cellular and molecular mechanisms that govern its dual role during viral infections remain unclear. Here, we discovered that mucosal deli...

Use of Telestroke Prior to Endovascular Stroke Treatment in Canada: Results from the OPTIMISE Registry

BACKGROUND: Telestroke allows rapid assessment of acute stroke patients for intravenous thrombolysis and endovascular thrombectomy (EVT). While its safety and efficacy for thrombolysis are well established, evidence regarding EVT decision-making via telestroke is scarce. METHODS:...

Self-organized spectral adjustment in echolocation sounds within group-flying bats

Self-organized behaviour has been extensively studied in group dynamics in animals, with a strong focus on movement coordination in species like fish and birds. By contrast, far less attention has been paid to vocal interactions within animal groups. Here, we unveil a self-organi...

Exploration of the genetic architecture of ANCA-associated vasculitis

Background Antineutrophil cytoplasmic antibody-associated vasculitis (AAV) is a complex autoimmune disease with distinct clinical and serological subtypes. Previous genome-wide association studies (GWAS) have identified several susceptibility loci, particularly within the major h...

Combined Effects of Sports Bra Support and Running Shoe Cushioning Influence Breast and Running Biomechanics in Female Runners

Background: Sports bras play a critical role in running, with implications for breast discomfort, pain, performance, potential injury risk, and exercise participation for many women. While breast movement has been analyzed across support levels, most studies focus on discrete tim...

High-Dose Gestational Irradiation Disrupts Fetal Mouse Brain Structure and Region-Specific Transcriptomic Profiles

Background/Objectives: Prenatal exposure to ionizing radiation can disrupt neurodevelopment, yet the region-specific structural and molecular responses of the developing brain remain incompletely understood. In particular, how gestational irradiation alters transcriptional progra...

Clinical outcomes of primary anterior cruciate ligament reconstruction with concomitant lateral meniscal posterior root tear repair versus isolated anterior cruciate ligament reconstruction: a systematic review and meta-analysis

Introduction Lateral meniscal posterior root tears (LMPRTs) commonly occur with anterior cruciate ligament (ACL) injuries, but clinical outcomes after concomitant repair remain unclear. Aim This systematic review and meta-analysis compared postoperative outcomes after ACL reconst...

Microfluidic Engineering of Microgels: A Review of Emerging Technologies, Materials, Fabrication Strategies, and Applications

Microparticles of hydrogels, also known as microgels, have garnered extensive attention due to their versatile properties and wide range of applications in different fields of science, technology, and medicine. Among the developed technologies to produce microgels, the precise co...

Metabolic dysfunction in chronic critical illness: mechanisms, clinical consequences and therapeutic perspectives

Advances in intensive care have improved survival from acute critical illness, leading to a growing population of patients with chronic critical illness (CCI), many of whom require prolonged organ support. This condition is associated with persistent catabolism, inflammation, and...

Cohomogeneity-one ruled hypersurfaces in CP2 and CH2

In this paper, we show how to construct a special class of ruled hypersurfaces in the nonflat complex space forms ℂ ⁢ ℙ 𝑛 and ℂ ⁢ H 𝑛 . This is done by taking an arbitrary smooth curve in a totally geodesic (complex) one-dimensional submanifold and erecting an orthogonal ruling o...

Heat Treatment Effects on Additively Manufactured Polymer Matrix Composites

Additive manufacturing (AM) of polymer matrix composites (PMCs) enables the fabrication of complex, structurally efficient parts, but the layer-wise thermal history intrinsic to processes such as material extrusion, vat photopolymerization, powder bed fusion, and direct ink writi...

Interfacial Strain and Inversion Domains in Coherent AlBScN/GaN Epitaxial Interfaces

Abstract Nitride ferroelectrics are among the emerging materials with promising potential for a wide range of electronic, optoelectronic, and memory applications because of their high remanent polarization, low growth temperature, and complementary metal-oxide-semiconductor (CMOS...

Intravenous and intranasal ketamine for borderline personality disorder to treat comorbid depression, BPD symptoms and suicidality: a systematic review

While psychotherapy is the standard form of treatment for borderline personality disorder (BPD), there are no pharmacological medications approved to treat this condition. Many individuals with BPD also experience depression and suicidal ideation, highlighting the need for effect...

Chronotherapeutic considerations for antiplatelet therapy in cardiovascular risk prevention – A systematic review

Summary: Background: Cardiovascular physiology exhibits circadian rhythms, including a morning surge in platelet reactivity and cardiovascular events. Aligning the timing of antiplatelet therapy with these rhythms may be a simple, cost-effective approach to improve clinical effic...

Local and global canopy height models reveal consistent large-tree forest conservation gaps despite low spatial agreement

Canada's coastal temperate rainforests are home to some of the world's largest trees. These forests support disproportionate carbon storage, high structural complexity, and habitat for a wide range of species. Historical logging focused on the most productive stands, combined wit...

No difference in alloimmunization of pregnant adults with sickle cell disease exposed to chronic versus on‐demand transfusions: A two‐center retrospective cohort study

Abstract Background Pregnant people with sickle cell disease (SCD) experience high morbidity and mortality, even when RBC transfusion is safe and available. There is a lack of consensus on transfusion use partly due to concern for alloimmunization. This study examined alloimmuniz...