McGill University Health Centre

A community-validated tool for clinical outcome calculation in multiple sclerosis: Consensus development and scenario-specific recommendations

Background: Reproducibility and comparability of disability outcomes remain major challenges in multiple sclerosis (MS) research. Definitions of disability progression vary widely across studies, and calculation criteria are often insufficiently documented to enable replication....

Osteosarcopenia Revisited: From Mechanisms to Management

Abstract Sarcopenia and osteoporosis are characterized by insufficient mass and function of skeletal muscle and bone, and often co-occur in older persons, a condition called osteosarcopenia. Loss of bone and skeletal muscle mass and function is driven by multiple risk factors tha...

Therapies for Cardiovascular‐Kidney‐Liver‐Metabolic Syndrome: Reappraisal of Fibrates

ABSTRACT Cardiovascular disease, chronic kidney disease (CKD), type 2 diabetes mellitus (T2DM), obesity and metabolic dysfunction‐associated steatohepatitis (MASH) frequently coexist and share overlapping pathophysiology, forming the proposed cardiovascular‐kidney‐liver‐metabolic...

The Metabolic Revolution in Dermatology: Obesity, Insulin Resistance, and Ultra-Processed Diets as Drivers of Skin Inflammation

Inflammatory dermatoses are increasingly linked to systemic metabolic factors. Obesity and insulin resistance create a pro-inflammatory milieu that affects the skin. Adipose tissue functions as an endocrine organ secreting adipokines and cytokines that drive chronic inflammation...

Platform ecosystem governance and its influence on the process of formation and institutionalization of new practices for development

This study examined how platform ecosystem governance mechanisms, as enacted through human intermediaries, influenced the formation and institutionalization of new practices among smallholder farmers in an ICT4D context. We conceptualize platform ecosystems as socio-technical sys...

Introducing Mid‐Level Dental Providers in Iran: Challenges and Opportunities

ABSTRACT Objectives The WHO Global Strategy and Action Plan on Oral Health 2023–2030 encourages innovative approaches such as shifting tasks from dentists to Mid‐level Dental Providers (MLDPs), who work independently to improve access to and equity in oral health. This study aime...

Statistical methods, outcome structures, and research designs in hybrid type II effectiveness-implementation studies: protocol for a scoping review

<ns5:p>Background Hybrid type II effectiveness-implementation studies evaluate health intervention and implementation strategy effectiveness simultaneously. While the emphasis on each “side” varies within hybrid type II studies, the focus of this review is those that attempt a mo...

Exploring Immersive Virtual Reality as an Approach to Improve School Participation–Related Constructs in Children With ADHD

ABSTRACT Background School participation is frequency and involvement from person–environment transactions, not diagnosis, per the International Classification of Functioning, Disability and Health (ICF) and the family of participation‐related constructs (fPRC). In this framework...

PTPN1 and PTPN2 cooperatively set interferon responsiveness thresholds that govern cancer immune evasion

Immune evasion by cancer cells remains a major barrier to the success of immune checkpoint blockade (ICB). In recent years, Protein tyrosine phosphatase non-receptor type 2 (PTPN2) has emerged as a promising and druggable target for cancer immunotherapy. Small-molecule agents cur...

MRI‐based deep learning models match or surpass physician performance for early detection and staging of avascular necrosis of the femoral head: A systematic review

PURPOSE: Efficient and reliable magnetic resonance imaging (MRI)-based diagnosis of early avascular necrosis of the femoral head (AVNFH) is essential for guiding treatment but remains challenging due to variability in clinician experience. Deep learning (DL) models offer a promis...

A Scoping Review on the Evidence for Virtual Reality Simulation in Surgical Training

Objective Simulation has become a mainstay in surgical education as it is proven to improve trainees’ surgical skills. Virtual reality is a relatively new technology that allows for high-fidelity surgical simulation for many surgical procedures across many specialties. However, t...

In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer

Metastatic cancer remains the leading cause of cancer-related mortality, yet tumor cell–intrinsic mechanisms restraining metastatic dissemination remain incompletely defined. Here, we perform an unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer x...

Acute respiratory distress syndrome in scrub typhus: a systematic review and meta-analysis

PURPOSE: Acute respiratory distress syndrome (ARDS) is an important complication of scrub typhus and is associated with substantial mortality. The primary objective of this systematic review and meta-analysis was to estimate the proportion of hospitalised patients with microbiolo...

A qualitative study on how and why families engage with diverse antenatal care systems in rural eastern Zimbabwe

Antenatal care (ANC) pluralism—meaning, pregnancy-related care and support drawing on local indigenous and biomedical forms of care—is essential to reducing pregnancy-related morbidity and mortality in culturally appropriate ways in sub-Saharan Africa. Yet, many current intervent...

Use of Hypnosis for Intra-Articular Steroid Injections in Children with Juvenile Idiopathic Arthritis

Objectives Intra-articular steroid (IAS) injections are a common treatment for Juvenile Idiopathic Arthritis (JIA) but can cause anxiety in children, particularly due to needle fear. To facilitate cooperation, general anesthesia is often used for younger children or those requiri...

Neonatal Point-of-Care Lung Ultrasonography: Techniques and Normal Findings

Point-of-care lung ultrasonography (POC-LUS) has become a routine bedside tool for evaluating respiratory status in many neonatal intensive care units. This article walks neonatologists through the fundamentals of its application-probe selection, system setup, and image acquisiti...