Mahidol University

Interfacial Electronic Regulation of GO/Na0.5Bi2.5Nb2O9 Aurivillius-Layered Perovskite Heterointerfaces for Enhanced Photocatalysis

Constructing heterointerfaces between semiconductor photocatalysts and carbonaceous materials is an effective strategy for enhancing photocatalytic performance. However, the role of graphene oxide (GO) in modulating the interfacial electronic properties of Aurivillius-layered per...

Estimating enteric fever seroincidence in rural western Cambodia: Findings from a population-based cross-sectional serosurvey

Background: Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi, remains an important cause of febrile illness in low- and middle-income countries (LMIC). However, the exact burden is difficult to estimate due to limitations in diagnosis and surveillance.Met...

Comparative Finite Element Modal Analysis of Reinforced Concrete Cantilever Beams with Four- and Six-Bar Longitudinal Reinforcement Layouts

This study compares the elastic modal characteristics of reinforced-concrete cantilever beams containing four and six 12 mm longitudinal reinforcing bars using three-dimensional finite element analysis (FEA) and an exploratory machine learning (ML) exercise. Beam geometry, materi...

Design Strategies for Heterologous Molecule Display Using Macrobrachium rosenbergii Nodavirus-like Particles: A Systematic Review

Virus-like particles (VLPs) are nanoscale platforms that can be engineered for heterologous molecule display. Among the available VLP platforms, Macrobrachium rosenbergii nodavirus-derived VLPs (MrNV VLPs) have emerged as a promising system for this purpose. Following the Preferr...

A novel framework for quantifying the clinical impact of substandard and falsified antimicrobials: Application to typhoid fever

Substandard and falsified (SF) medicines are a neglected public health threat, with an estimated 7% of antimicrobials in low- and middle-income countries being SF. However, quantifying their clinical impact remains challenging. We developed a general framework for estimating popu...

Assessing agricultural water scarcity at the sub basin level using AWARE and water scarcity footprint in the Phetchaburi River Basin Thailand

Water scarcity is an increasingly critical constraint on sustainable agricultural development in Thailand, where irrigation accounts for most freshwater consumption. This study applied the Available Water Remaining (AWARE) index and the Water Stress Index (WSI) to assess water sc...

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will p...

Prothrombin complex concentrate (PCC) vs. non-PCC strategies for warfarin reversal in left ventricular assist device recipients: A systematic review and meta-analysis

Background Left ventricular assist devices (LVADs) prolong survival in end-stage heart failure, and warfarin thromboprophylaxis is recommended to prevent device thrombosis and thromboembolic complications. When bleeding occurs or emergency surgery is required, rapid anticoagulati...

NECTIN2 depletion impairs migration and invasion in MDA-MB-231 breast cancer cells through LIMK1-associated cytoskeletal remodeling

Breast cancer (BC) is the most commonly diagnosed malignancy in women, with triple-negative breast cancer (TNBC) representing the most aggressive subtype that is associated with poor clinical outcomes. Identifying novel biomarkers or therapeutic targets is therefore of great impo...

Medication errors in home care settings: a 13-year retrospective cohort study in the Ramathibodi Poison Center

INTRODUCTION: Medication errors are a leading cause of preventable harm worldwide, yet evidence has predominantly focused on healthcare settings, with limited data from home care, particularly in Southeast Asia. METHODS: We conducted a retrospective cohort study using 2011-2023 d...

The effect of the respiratory rate on mechanical power and patient outcomes – a systematic review

INTRODUCTION: Mechanical power (MP) is associated with worse clinical outcomes. Respiratory rate (RR) is a key component of MP. The aim of this systematic review was to assess whether, among mechanically ventilated adult ICU patients, a low versus high RR is associated with diffe...

Gamma irradiation-induced metabolic reprogramming as a determinant of radiation tolerance in thai rice germplasm for space agriculture

Abstract Radiation beyond Earth’s atmosphere poses a major challenge for space agriculture by affecting seed viability and plant establishment. As a controllable terrestrial analogue of cosmic radiation, gamma (γ) irradiation provides a practical model for evaluating crop resilie...

Shared and Distinct T-Cell Receptor Characteristics of CD4+ and CD8+ Drug-Specific T-Cells In Vitro Generated from Healthy Donors and Hypersensitive Patients

Abstract The initiation of T-cell-mediated drug hypersensitivity reaction requires the formation of a human leukocyte antigen (HLA)-peptide-drug-T-cell receptor (TCR) complex. While specific interactions between HLA molecules and drug antigens are well-defined, the characteristic...

Global Prevalence and Specificity of Red Blood Cell Antibodies in Blood Donors: A Systematic Review and Meta-Analysis

Background: Red blood cell (RBC) antibody screening in blood donors is a key component of transfusion safety. However, reported prevalence and antibody specificities vary widely across studies, and a consolidated global estimate remains limited. This study aimed to quantify the p...

Single-cell morphological responses as predictors of ciprofloxacin resistance in Acinetobacter baumannii

ABSTRACT The rise of antimicrobial resistance (AMR) coincides with a declining pipeline of new antibiotics, underscoring the urgent need for rapid and accurate antibiotic susceptibility testing (AST). Single-cell AST approaches offer the potential to shorten diagnostic turnaround...

Human scFv inhibiting broad coronavirus replication: a pandemic preparedness candidate

The ongoing emergence of zoonotic coronaviruses (CoVs) and the rapid evolution of viral variants underscore the need for broadly active antiviral agents. The relatively conserved S2 subunit of the coronavirus spike protein is an attractive target for developing pan-coronavirus th...

Discovery of Bis-ThioureaDerivatives as Human DNATopoisomerase IIα Inhibitors with Potent Anticancer Effects

Abstract DNA topoisomerase IIα (Topo IIα) is essential for maintaining genomic stability during DNA replication and mitosis and is highly expressed in cancer cells, making it a promising target for anticancer therapy. In this study, bis-thiourea derivatives were investigated for...

When Clinicaland Metabolomics Data Work Together:A Comparative Framework for Multimodal Disease Classification acrossMachine and Deep Learning

Abstract Disease classification using clinical and metabolomics data increasingly relies on multimodal integration, yet the complementary and comparative contributions of these modalities remain poorly understood. Most existing frameworks prioritize predictive performance without...

Thai Modified Dental Anxiety Scale (Thai-MDAS): cross-cultural adaptation, psychometric validation, and preliminary diagnostic accuracy

Dental anxiety is a prevalent barrier to dental care worldwide. The Modified Dental Anxiety Scale (MDAS) is a widely used, brief self-report measure with established cross-cultural validity in numerous languages, yet no validated Thai-language version currently exists. This study...

Technical note: reconstructing dose distributions from manually planned electron boosts in breast radiotherapy

Purpose In breast radiotherapy, delivery of manually-calculated electron boosts limits retrospective dose–response analyses as dose distribution is unavailable. This work evaluates the feasibility of reconstructing dose distributions from manually planned electron boosts in breas...