Mahidol University

Integrative molecular identification and mitochondrial genetic diversity of cryptic Anopheles vectors in malaria hotspots of northwestern Thailand

The Anopheles barbirostris complex comprises several sibling species capable of transmitting malaria and lymphatic filariasis and is increasingly recognised as a potential contributor to residual malaria transmission in the Greater Mekong Subregion (GMS). However, the morphologic...

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...

Implicit Health Beliefs and Suicidal Ideation in Chinese College Students: The Serial Mediating Roles of Lifestyle Behaviors and Anxiety Symptoms

The growing prevalence of mental health problems and suicidality among university students highlights the need to identify potentially modifiable psychological pathways that can inform preventive interventions. This study investigated the association between implicit health belie...

Seeking Common Ground While Respecting Differences

This study aimed to systematize and validate a conflict resolution framework for Thai Sunni Muslims, particularly the Salaf, based on Muhammad Rashid Rida’s principle of “seeking common ground while respecting differences.” The framework was first constructed through normative sy...

Environmental and host-associated determinants of microbiome variation in the brown dog tick Rhipicephalus linnaei in Thailand

Abstract Background The brown dog tick, Rhipicephalus linnaei , is an important vector of veterinary and zoonotic pathogens worldwide. The composition of the tick-associated microbiome may influence tick physiology, adaptation, and vector competence; however, factors shaping the...

Prey restoration facilitates early tiger recolonization in a human‐dominated protected area of Thailand

Abstract Introduction Rewilding is an important ecological restoration practice for sustaining ecosystem function. Reintroduction of large‐ and medium‐sized prey can facilitate recolonization by predators such as tigers ( Panthera tigris ) in fragmented habitats. Objective We exa...

Advances in Organoid Technology: Bridging the Gap Between Research and Therapy

Organoids Are Us is a symposium series that provides a snapshot in time of the latest and emerging developments in organoid technology [...]

In vitro assessment of cell proliferation and migration induced by crude lychee seed extract in human gingival fibroblast cells (HGF-1)

Abstract Background: Human gingival fibroblasts (HGFs) are central regulators of oral wound healing. Oxidative stress impairs fibroblast viability and motility, potentially delaying wound healing. Lychee seeds are rich in antioxidants, such as phenolics and flavonoids. Their anti...

Development, safety profile, and wound-healing efficacy of a quality-controlled Oroxylum indicum (L.) Kurz. fruit extract ointment in non-infectious and Staphylococcus aureus-infected wound models

Pheka ( Oroxylum indicum (L.) Kurz.) is a Thai medicinal plant that has been used for traditional purposes for a long time. Pheka extracts possess significant antioxidant and antibacterial properties, yet their topical application for wound healing remains underexplored. This stu...

Toward Understanding the Subjectivity of Teacher Well-Being: An Application of Q Methodology

Abstract Although many instruments exist to assess teacher well-being (TWB), this study developed the PERMA Q Sort (PERMA-Q) and applied Q methodology to examine the subjectivity of TWB. Data were collected through a card-sorting task and semi-structured interviews with 62 Thai s...

A Scoping Review of Integrated Care Models for Managing Depression in Older Adults

Background: Depression is a major health issue among older adults and is frequently accompanied by chronic physical conditions. Conventional care of depression in older adults is delivered through primary care settings and often fails to address the complex interactions between m...

Exploratory spatial transcriptomic analysis of compartment-specific recurrence-associated gene expression in gastric cancer

We hypothesized that the prognostic value of immune and stromal gene expression is spatially dependent—specifically, signals driving homeostasis in the superficial mucosa may differ functionally from those at the deep invasive front. We analyzed formalin-fixed paraffin-embedded s...

Uncertainty, institutional quality and strategic commitment: US MNEs’ sequential acquisitions in emerging economies

Purpose This study examines how multinational enterprises (MNEs) respond to demand and political uncertainty in emerging markets through sequential acquisition as a form of supplemental foreign direct investment (FDI). Drawing on real options theory, it investigates how host coun...

Community perceptions, trust, and experiences of malaria clinical research and participation in rural Cambodia

INTRODUCTION: Understanding community perspectives on malaria treatment and research participation is important for designing ethically appropriate community engagement strategies, strengthening informed consent, and improving the conduct of clinical research while supporting dis...

Diagnostic yield and impact of internal transcribed spacer sequencing from clinical specimens on antifungal management in patients with suspected fungal infection

Internal transcribed spacer (ITS) sequencing has been increasingly used for the diagnosis of fungal infection. However, data on its real-world clinical utility are limited. We retrospectively evaluated the diagnostic yield from direct clinical specimens using the final diagnosis...

Quality and concordance of international paediatric sepsis guidelines: a cross-sectional appraisal from the SENTINEL International study

Objectives To evaluate the methodological quality of hospital-specific paediatric sepsis clinical practice guidelines (CPGs) from sites participating in an international study using the Appraisal of Guidelines for Research and Evaluation II (AGREE II) tool and to assess the consi...

Deep3DCCS: Geometry-Driven Collision Cross Section Prediction from Multi-View Molecular Projection Tensors

Abstract Collision cross section (CCS) measurements from ion mobility–mass spectrometry improve confidence in molecular identification in metabolomics and lipidomics and reduce false-positive annotations in untargeted analyses. However, experimental CCS coverage remains incomplet...

Valve Outcomes in Temporary Tricuspid Valve Detachment for Transatrial Ventricular Septal Defect Closure

Background In ventricular septal defect (VSD) closure, accurately defining the margins of the VSD is essential for success. Transatrial tricuspid valve detachment (TVD) aims at improving visualization, which is often impaired by the tricuspid valve apparatus. However, this may af...

Perivascular immune organization and spatial architecture are associated with immunotherapy response in non-small cell lung cancer

Clinical responses to immune checkpoint inhibitors (ICIs) in non-small cell lung cancer (NSCLC) remain highly heterogeneous and PD-L1 expression alone has limited predictive performance. Emerging evidence suggests that therapeutic response depends not only on immune cell abundanc...

Rethinking Mathematical Knowledge: A Nativist Approach

This paper develops a nativist approach to mathematical knowledge as an alternative account within the philosophy of mathematics. Rather than beginning with the ontological status of mathematical objects, it argues that any satisfactory account of mathematical knowledge should ad...