Mahidol University

The anthropogenic fingerprint on emerging infectious diseases

Abstract Emerging infectious diseases are a hallmark of the Anthropocene 1,2 . Human-driven ecosystem changes and human–wildlife–livestock contact can drive the emergence of zoonotic and vector-borne diseases 3–5 , but how much these processes shape landscapes of outbreak risk is...

Changes in alcohol-consumption frequency and factors associated with the magnitude of decreases during the COVID-19 pandemic: a nationally representative cross-sectional survey in Thailand

We described changes in alcohol-consumption frequency among current drinkers in Thailand during the COVID-19 pandemic and examined factors associated with a larger decrease among those who reduced their drinking frequency. We analysed a nationally representative face-to-face cros...

A Registry-Informed Framework for Earlier Detection of Esophageal Adenocarcinoma in Thailand: Evidence from a 16-Year Cohort Study

Esophageal cancer is frequently diagnosed at an advanced stage, limiting opportunities for curative treatment and contributing to poor clinical outcomes. We aimed to identify clinicopathological predictors of advanced-stage presentation and use these findings to inform a registry...

A hypothesis-driven perspective on GLP-1R-β-catenin pathway crosstalk in astrocyte plasticity and endogenous neural repair

Astrocytes exhibit pronounced, context-dependent plasticity following central nervous system (CNS) injury; however, their capacity for fate remodeling remains constrained by chromatin architecture, lineage-stabilizing signaling networks, inflammatory and metabolic states, and dis...

Eating disorder knowledge, attitudes, and awareness among Thai high school students: a cross-sectional study highlighting gaps in oral health awareness

Abstract Objectives This study assessed high school students’ knowledge of eating disorder types and their health consequences, including oral health consequences; evaluated eating attitudes and eating disorder risk, and examined associations between participant characteristics a...

The KH-like CTD of Prp5 is conserved and essential for splicing

Pre-mRNA splicing is a fundamental process in eukaryotic gene expression. The RNA helicase Prp5 bridges U1 and U2 snRNPs during spliceosome assembly and enhances splicing fidelity. While the N-terminal domain (NTD) of Prp5 is well characterized, the C-terminal domain (CTD) remain...

Fourth-generation chimeric antigen receptor T cells targeting mucin 1 for enhanced anti-tumor activity against breast cancer

Breast cancer (BC) is the leading cause of cancer-related mortality worldwide, and current treatments are unmet clinical needs. Although chimeric antigen receptor (CAR) T cells have been approved for hematological malignancies, their advancements in solid tumors are challenging....

Tapetal-like reflex in RPGR-associated retinal dystrophies: two cases with distinct phenotypes

Retinitis pigmentosa GTPase regulator (RPGR) mutations are associated with X-linked inherited retinal diseases (IRDs), with variable phenotypes including retinitis pigmentosa (RP), cone-rod dystrophy (CRD), and cone dystrophy (CD). Tapetal-like reflex (TLR) is commonly observed i...

Mitral Valve Lithotripsy With SmartCrack Balloon for Severe Calcified Mitral Stenosis: First‐in‐Human Experience

Background Mitral stenosis due to mitral annular calcification and calcific rheumatic heart disease (CRHD) remains challenging to treat. This first‐in‐human study evaluated the safety and feasibility of the dedicated SmartCrack lithotripsy balloon in patients with severe mitral s...

Adverse Remodeling and Prognostic Significance of the Systemic Right Ventricle Across Congenital Heart Disease Subtypes

Patients with congenitally corrected transposition of the great arteries (ccTGA), atrial-corrected transposition (acTGA), and right-ventricular-dominant univentricular heart (UVH) are predisposed to systemic right ventricular dysfunction (sRVd). However, lesion-specific differenc...

Immunogenicity and safety of high-dose versus standard-dose quadrivalent inactivated influenza vaccine in patients living with HIV: a randomized controlled trial

Influenza remains a major cause of morbidity in people living with HIV (PLWH), and despite recommendations for annual vaccination with the standard-dose (SD) quadrivalent inactivated influenza vaccine (IIV4), immune responses are often suboptimal in this population. To address th...

Effects of experimental Plasmodium collidatum infection in resident spotted doves (Spilopelia chinensis) in Thailand

Avian malaria is a mosquito-borne disease caused by Plasmodium apicomplexan protozoan parasites, such as the host-generalist P. collidatum . The disease is associated with high virulence, characterized by severe parasitemia and visceral organ damage leading to high mortality. In...

COVID-19 lockdown and coverage of maternal health and nutrition care in rural West Bengal, India: a single interrupted time-series analysis

Abstract While COVID-19 lockdowns globally disrupted healthcare, the extent of changes in India’s maternal health and nutrition services coverage in rural settings requires further empirical investigation. Utilizing data from 57,371 pregnancies recorded between January 2012 and D...

A randomized trial of nefopam for postoperative pain management in obstructive sleep apnea patients undergoing uvulopalatopharyngoplasty

Abstract Objective Uvulopalatopharyngoplasty (UPPP) is a surgical treatment for obstructive sleep apnea that often results in significant postoperative pain. Given the risks associated with opioid use in patients with obstructive sleep apnea, multimodal analgesia is preferred. Th...

Bridging historical antigenic profiling and whole-genome taxonomy in Rickettsia

Abstract Historically, rickettsial diseases were classified primarily through antigenic profiling and serotyping, an approach that was later superseded by molecular taxonomy and phylogenetics. Recent advances in whole-genome sequencing (WGS) have revealed substantial taxonomic am...

Convergence Rates of Levenberg–Marquardt Regularization Under General Source Conditions

We investigate the convergence of the Levenberg–Marquardt (LM) iterative regularization method for linear ill-posed inverse problems in Hilbert spaces under general source conditions characterized by admissible index functions. We introduce admissibility conditions tailored to th...

Phylogenetic inconsistency of pairwise SNP clustering for inferring tuberculosis transmission in a high-burden, endemic setting: a case study from Thailand

ABSTRACT Whole-genome sequence analysis is now widely used to delineate tuberculosis transmission clusters. A standard practice is to cluster bacterial isolates based on a fixed maximum genome-wide pairwise single nucleotide polymorphism (pwSNP) distance threshold. In this study,...

Randomized generic-sequence crossover pharmacokinetic study of innovator and two generic tacrolimus formulations in kidney transplant recipients according to CYP3A inhibitor co-administration

Tacrolimus is a narrow therapeutic index immunosuppressant widely used in kidney transplantation. Although generic formulations reduce treatment costs, pharmacokinetic comparability under CYP3A inhibitor co-administration remains insufficiently studied. We conducted a prospective...

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...

Integrative molecular identification and mitochondrial genetic diversity of cryptic Anopheles vectors in malaria hotspots of northwestern Thailand

The Anopheles barbirostris complex comprises several sibling species capable of transmitting malaria and lymphatic filariasis and is increasingly recognised as a potential contributor to residual malaria transmission in the Greater Mekong Subregion (GMS). However, the morphologic...