Ludwig-Maximilians-Universität München

Resolving the Performance Feedback Puzzle: CEO Psychopathy, Heterogeneous Emotional Responses to Aspiration Gaps, and Risk-Taking

Theoretical perspectives provide conflicting predictions regarding how firms adjust risk-taking in response to performance–aspiration gaps. The behavioral theory of the firm attributes increased risk-taking to problemistic search under negative gaps, whereas threat–rigidity theor...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Charting Endocrine Progenitors Across Species and Organs

ABSTRACT Hormone‐producing cells in the pancreas and intestine regulate whole‐body metabolism and are dysregulated in obesity and diabetes. A deeper understanding of endocrine lineage formation (endocrinogenesis) in these organs is essential to elucidate the healthy state and dis...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Timing of PCI in Patients Undergoing Transcatheter Aortic-Valve Implantation

BackgroundApproximately one half of patients undergoing transcatheter aortic-valve implantation (TAVI) have concomitant coronary artery disease. Although percutaneous coronary intervention (PCI) is often performed before TAVI, the preferred treatment strategy has not been establi...

Robotic-assisted compartmental dissection for retroperitoneal sarcoma: a feasibility study on cadavers with the da Vinci Xi system

Abstract Purpose Retroperitoneal sarcomas (RPS) pose major technical challenges because of their size, anatomical complexity, and need for multivisceral resection. We evaluated the feasibility of a standardized robotic approach for right- and left-sided retroperitoneal sarcoma (R...

Engineering Atomically Precise Cu 4 I 4 Nanoclusters With Integrated Adsorption and Hydrogenation Functions for Efficient Photocatalytic Nitrate‐to‐Ammonia Conversion

ABSTRACT Photocatalytic nitrate reduction to ammonia offers a sustainable route that couples environmental remediation with nitrogen resource utilization. However, this transformation suffers from sluggish kinetics and insufficient hydrogenation, leading to poor selectivity and e...

The ongoing first-line treatment race for metastatic pancreatic ductal adenocarcinomas: will a tough disease lose its horror?

Pancreatic ductal adenocarcinomas (PDACs) are found to account for more than 5% of all cancer-related deaths worldwide. The 5-year survival rates are still low (<5% for in the metastatic setting). In patients with metastatic disease, combination chemotherapy regimens are currentl...

Locomotion optimizes sensory representations through a computational principle shared by rodents and primates

Behavior modulates the activity of sensory systems in multiple ways: from gain changes in individual neurons to changing interactions in neural populations. These effects are not universal; while movement has a strong influence on sensory coding in rodents, its impact on primates...

PLASTID ENVELOPE ION CHANNELS (PEC1/2) link Ca 2+ and jasmonic acid signaling in plant cells

Plants constantly encounter adverse environmental interactions. One organelle is particularly specialized in stress signaling and phytohormone synthesis: the plastid. Calcium (Ca 2+ ), a key second messenger, is known to intersect with cellular phytohormone signaling networks. Wh...

Pediatric intensive care follow-up in Germany is rarely established and highly heterogeneous: a nationwide survey of 20 PICUs

BACKGROUND: Survival after pediatric critical illness has improved substantially, but many survivors and their families experience long-term physical, neurocognitive, psychological and social sequelae, summarized as post-intensive care syndrome in pediatrics and in families. Stru...

Disruption of sphingolipid metabolism promotes tau seeding through endolysosomal membrane rigidification and rupture

Endolysosomal dysfunction is a hallmark of Alzheimer’s disease and related tauopathies, yet underlying mechanisms remain poorly understood. This study investigates the role of sphingolipid metabolism in maintaining endolysosomal membrane integrity and its impact on tau aggregatio...

Could NQO1 genotypes impact the results of clinical trials with idebenone?

Carelli et al. argue that new insights into how NQO1 influences the response to idebenone warrant reevaluating the results of previous clinical trials, including those in Friedreich ataxia and Duchenne muscular dystrophy, using patient stratification by NQO1 genotype.

Psychological symptoms in individuals with Spinal Muscular Atrophy (SMA) and their caregivers – results from a nation-wide study in Germany

Abstract Background This study investigates the prevalence and associations of psychological symptoms in individuals with Spinal Muscular Atrophy (SMA) and their caregivers, utilizing data from a cross-sectional, observational assessment conducted in Germany. Participants were re...

Community: Component based differential cell communication analysis in large multi-sample case-control scRNAseq datasets

Abstract Cell-cell communication is essential for physiological tissue function. In disease, communication often gets disbalanced by changes in the tissue cell type composition, fraction of cells engaged in communication, and changes in expression levels of ligands, receptors and...

Social Media Savvy? The Use and Effectiveness of Political Parties’ Issue Strategies Across Platforms in the German Federal Election Campaign 2025

How does the ever-growing relevance of social media shape political campaigning? A vibrant public and academic debate addresses the role of social media in elections and democratic processes. Yet, despite a surge in research, we still know little about the extent to which politic...

Effect of periprosthetic greater trochanter fractures (Vancouver AG) on primary stability of the femoral stem in total hip arthroplasty: a biomechanical micromotion analysis

Abstract Purpose Primary stability is a crucial factor for the long-term success of cementless total hip arthroplasty (THA). Periprosthetic fractures represent an important cause of loss of primary implant stability. While Vancouver AG fractures rarely lead to stem loosening, the...

Proving Total Correctness of Top-Down Solvers with Widening and Narrowing

Abstract The top-down solver TD is a generic fixpoint algorithm that can be used to compute partial post-solutions of equation systems for abstract interpretation. We consider two extensions of the TD to deal with infinite strictly ascending chains. For the TD extended with warro...

A comparison of body image components, including attentional bias and body appraisal, in adolescents with anorexia nervosa or depression, and non-clinical controls

Abstract Background Body image disturbance (BID) is increasingly recognized as a transdiagnostic factor. Beyond its established role in anorexia nervosa (AN), specific components of BID are also associated with the development and maintenance of psychopathology in adolescent Majo...

The cesium oxidometalate hydroxides Cs 5 [ M O 4 ][OH] with M = Ge, Cr

Abstract Two cesium oxidometalate hydroxides were synthesized by hydrolysis of the respective cesium oxidometalates. Cs 5 [CrO 4 ][OH] crystallizes in the monoclinic space group C 2/ m with a = 7.8534(4) Å, b = 11.5276(7) Å, c = 12.8187(7) Å, β = 106.346(3)°, V = 1,113.58(11) Å 3...