Ludwig-Maximilians-Universität München

Conservative and surgical treatment of wrist osteoarthritis: a systematic review

INTRODUCTION: Wrist osteoarthritis leads to pain and functional impairment. Despite conservative treatment options, surgery remains a central therapeutic component. In Germany, the number of patients rose from over 472,000 cases in 2018 to more than 580,000 in 2024. This review e...

Clinical Longitudinal Evaluation After Regimen Stop (CLEAR) of Dupilumab in Chronic Rhinosinusitis With Nasal Polyps (CRSwNP)

ABSTRACT Background Long‐term management strategies for severe chronic rhinosinusitis with nasal polyps (CRSwNP) increasingly include biologic therapy targeting Type 2 inflammation. However, data on outcomes after complete discontinuation of dupilumab following sustained disease...

Exploring the effect of a science-themed career exhibition on South African children’s perceptions of scientists

Abstract Background The Draw-a-Scientist Test (DAST) has been widely employed to explore individuals' perceptions of scientists, aiming to identify stereotypical images that could influence attitudes towards science-related career decisions. Purpose This study examines young chil...

Disentangling surface and bulk properties of Ta3N5 photoanodes

Abstract Understanding how material and defect characteristics govern photoelectrochemical performance is essential for developing efficient and stable photoelectrodes. Although bulk properties are often emphasized, surfaces and interfaces can equally determine activity and stabi...

Motivation to Change, Therapeutic Alliance and Outcome—A Complex Interaction in Patients With Anorexia Nervosa

ABSTRACT Objective The role of the therapeutic alliance (TA) in treatment outcomes of anorexia nervosa (AN) appears to be less substantial than in other disorders. However, the therapeutic process is a complex trajectory with many variables influencing each other. Hence, investig...

Data-driven mapping of known and novel fluid biomarker progression profiles in genetic frontotemporal lobar degeneration

Abstract Introduction Recent proteomic studies have identified both established and novel proteins in genetic frontotemporal lobar degeneration (FTLD). However, it remains unclear at what point in the disease these proteins deviate from normal levels and how their trajectories re...

Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert®MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries

Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organisation (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRD...

Impact of structured reporting on interpretability of PSMA PET/CT in prostate cancer staging—towards standardised clinical implementation

OBJECTIVE: This study assessed the impact of structured reporting (SR) compared with conventional free-text reporting (FTR) on report quality for PSMA PET/CT for diagnosis and staging of prostate cancer (PC) using a dedicated template. MATERIALS AND METHODS: Fifty consecutive pat...

Recovery of gait after ankle fracture surgery following early mobilization and weight-bearing

BACKGROUND: Ankle fractures are among the most common fractures in adults. Despite significant advancements in surgical techniques, the postoperative treatment regimens remain conservative. This study aims to objectively evaluate gait recovery following early mobilization and wei...

The World Psychiatric Association (WPA) Guideline on Schizophrenia Spectrum Disorders Management for Low- and Middle-Income Countries

There is a pressing need to address the unique challenges of managing Schizophrenia Spectrum Disorders (SSD) in Low- and Middle-Income Countries (LMICs), where mental health resources are scarce and unevenly distributed. To develop this evidence-based guideline, we conducted a sy...

Combination of antibody-based screening methods for the identification and quantification of Legionella pneumophila in process water

Legionnaires’ disease is a severe and often fatal pneumonia primarily caused by the inhalation of aerosols contaminated with the waterborne pathogen Legionella pneumophila serogroup 1. While conventional culture-based detection is often standard for monitoring evaporative cooling...

Artificial Intelligence in Orthodontics: Part 2—Data Preparation and Performance Evaluation

Artificial intelligence (AI) is increasingly integrated into orthodontic research and clinical workflows. Yet, the reliability and clinical value of these systems depend fundamentally on the quality of the data used to train them and the rigour with which their performance is eva...

What constitutes successful collaborative conjecturing-and-proving processes? Relations between beginning undergraduates’ resources, conjecturing-and-proving processes, and performance

Abstract Students’ difficulties with mathematical argumentation, conjecturing, and proving, as well as with collaborating effectively, have long been documented in the literature. While there is some research on what constitutes successful proving processes, systematic investigat...

The German media debate on taxing meat and other animal-based foods: a framing analysis

OBJECTIVE: Consumption of meat - red and processed meat in particular - exceeds recommended levels in most high-income countries. Higher taxes on meat have been proposed as a response, but have proven difficult to implement due to political controversy. We examined the role of fr...

How ice apron loss and permafrost degradation promoted the Platteikogel rock slope failure: a thermo-mechanical reconstruction

Abstract. The Alpine cryosphere changes at unprecedented speed, affecting the thermal, hydrological, and mechanical state and behaviour of rock slopes. While numerous studies investigated singular drivers for progressive rock slope failures, the knowledge of hydro-thermo-mechanic...

Reproducible analysis and structured dataset for "Toward clinical-grade deep learning in coronary angiography: a systematic review"

This record contains the structured dataset and analysis code accompanying the systematic review "Toward clinical-grade deep learning in coronary angiography". The dataset comprises extracted study characteristics and quality appraisal results for the included studies, together w...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Investigating changes in the blood-brain barrier in schizophrenia spectrum disorders: design and methodology of a longitudinal dynamic contrast-enhanced MRI study

Schizophrenia spectrum disorders (SSDs) are clinically and biologically heterogeneous and lack reliable biomarkers for stratification, treatment response and course prediction. Evidence from postmortem, fluid biomarker, and neuroimaging studies suggests that changes in the blood-...

Fostering the collaborative diagnosis of cross-domain skills in video-based simulations: An analysis of collaborative diagnostic activities

Abstract Teachers’ ability to assess pupils’ knowledge and skills is a crucial component of their daily responsibilities, as accurate diagnoses influence both the support provided to pupils and their learning outcomes. Traditionally, diagnosing pupils’ skills is an individual tas...

From Gene Editing to Exogenesis: Pigs as a Source of Immune-compatible Organs for Transplantation

The persistent shortage of human organs for transplantation has intensified efforts to develop alternative sources, specifically xenotransplantation and exogenesis. Xenotransplantation uses genetically engineered pigs to provide organs, tissues, and cells for clinical use. Signif...