Ludwig-Maximilians-Universität München

Assessment of the effectiveness of protein in critical illness: the role of statistical shortcomings in explaining discrepancies between observational studies and randomized controlled trials

Until 2023, recommendations for prescribing protein to critically ill patients were largely based on observational studies and non-randomized interventions. Several large, multicentre non-randomized studies of intervention conducted between 2009 and 2017 consistently reported tha...

Tracheal tuft cell-released leukotrienes promote antibacterial immune responses

SUMMARY Tuft cells act as crucial sentinels in the airways that detect bacterial metabolites. In response, tuft cells release signaling molecules that trigger immune responses essential for clearing the infection. The molecular mechanisms driving immune cell activation following...

The cesium oxidometalate hydroxides Cs 5 [ M O 4 ][OH] with M = Ge, Cr

Abstract Two cesium oxidometalate hydroxides were synthesized by hydrolysis of the respective cesium oxidometalates. Cs 5 [CrO 4 ][OH] crystallizes in the monoclinic space group C 2/ m with a = 7.8534(4) Å, b = 11.5276(7) Å, c = 12.8187(7) Å, β = 106.346(3)°, V = 1,113.58(11) Å 3...

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

Microvascular remodeling and endothelial dysfunction across the post-COVID-19 spectrum: a prospective observational case-control study

<title>Abstract</title> Background Post-viral diseases, including post-COVID-19 syndrome (PCS) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), cause substantial long-term morbidity. Persistent cardiovascular risk after acute infection highlights the need for acce...

Tracking funding disparities in global health aid with machine learning

Abstract Reducing the global burden of disease is crucial for improving health outcomes. However, misalignment between health aid and country-level disease burden leaves vulnerable populations without the necessary support for major health challenges, particularly in the least de...

Maribavir in lung transplant recipients with cytomegalovirus infection: real-life experience

Abstract Introduction Cytomegalovirus remains a major challenge in LTx recipients. Despite advances in antiviral therapy, refractory and resistant CMV infections persist, and real-world data on maribavir, a recently approved UL97 kinase inhibitor, are limited. Methods We retrospe...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...

Ultra-compact plasma photocathode in a hybrid wakefield accelerator

Abstract Plasma-based particle accelerators, realized by driving plasma waves with either an intense laser pulse or particle beam, offer accelerating fields orders of magnitude higher than conventional accelerators. This enables sources of highly relativistic electron beams with...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

Regression of Left Ventricular Hypertrophy in Primary Aldosteronism

BACKGROUND: Left ventricular hypertrophy (LVH) is frequently identified in patients with primary aldosteronism; determinants of LVH regression after targeted treatment are debated. We assessed LVH prevalence before and after adrenalectomy or mineralocorticoid receptor antagonist...

Brassinosteroid-regulated transcription factors confer epigenetic changes that repress plant immunity

Abstract When organisms encounter pathogens, they rapidly activate complex defense programs to ensure survival. While these immune responses are vital, they often also incur trade-offs, such as reduced growth and development and must therefore be tightly controlled 1,2 . In this...

Selective Cell Death of Adrenocortical Cells by Pharmacological Activation of Mutant KCNJ5

BACKGROUND: Primary aldosteronism is frequently caused by mutations in the KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) gene, encoding a G-protein inwardly rectifying potassium channel. These mutations disrupt the channel’s selectivity filter, permitting abn...

Elevated IL-10 is Linked With the Expansion of T-bethighCD21low B Cells in Patients With Common Variable Immunodeficiency

Abstract Common variable immunodeficiency (CVID) is frequently complicated by autoimmune and inflammatory manifestations associated with profound immune dysregulation (CVIDc), including expansion of T-bet high CD21 low B cells (CD21 low B cells). Elevated serum IL-10 levels have...

CX3CR1 Modulates Migration of Resident Microglia Towards Cortical Laser‐Induced Lesions

Microglia are innate immune cells of the central nervous system (CNS). They extend their processes and migrate toward injuries in vivo. However, how the fractalkine receptor (CX3CR1) influences microglial migration remains unknown. Label-free proteomic profiling predicted changes...

Longitudinal progression, metrics, age-dependence, and modifiers of ataxia severity in SCA27B: a multicentre study of 219 patients

Background Spinocerebellar Ataxia 27B (SCA27B) is a novel, frequent and likely treatable late-onset autosomal-dominant ataxia caused by GAA repeat-expansions in FGF14 . For understanding disease evolution and imminent trial planning, metrics of the most widely used clinical outco...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...

Patient selection for PRRT rechallenge in neuroendocrine tumors: impact of initial response duration on outcomes

BACKGROUND: Patient selection for rechallenge peptide receptor radionuclide therapy (re-PRRT) in neuroendocrine tumors (NET) remains poorly defined. As re-PRRT is increasingly considered in clinical practice, identifying patients most likely to benefit has become a critical yet u...

CODAC: Constraint-based Deep Active Clustering

Abstract Constraint-based Deep Active Clustering (CODAC) integrates actively selected pairwise constraints into deep representation learning to efficiently improve existing cluster structures, even under tight query budgets. CODAC encodes the constraint information into the embed...

AllostericInhibitors of Erythromycin Resistance MethyltransferaseReverse Antibiotic Resistance

Abstract Methylation of a critical adenine residue of the 23S rRNA residing in the nascent exit tunnel of the bacterial ribosome, by Erythromycin resistant methyltransferases (Erms), reduces binding of macrolide, lincosamide, and streptogramin B (MLSB) class of antibiotics and co...