Ludwig-Maximilians-Universität München

A comprehensive phylogenomic framework for brachiopod evolution among lophotrochozoans

Brachiopods appeared early in the Cambrian radiation and represent an important clade for understanding the origin of animal body plans and the evolution of biomineralized structures. A robust phylogenetic framework of the living representatives is needed to answer persistent que...

Endosomal Escape of siRNA Polyplexes: A Molecular Dynamics Perspective on Underlying Mechanisms

ABSTRACT To achieve a therapeutic effect, nanoparticles delivering nucleic acids must facilitate endosomal escape (EE) of their cargo. Despite extensive research, the mechanisms that lead to an effective EE are not sufficiently understood. Herein, we compare the EE behavior of fo...

Language-derived mental object load suppresses posterior alpha power

Language and vision are two primary source modalities of information for humans. To uncover shared and unique mental representations across linguistic and visual inputs, one approach is to test the extent to which a certain neural signature is shared. In the current EEG study, we...

Beyond Principlism: A Cosmopolitan and Care Ethics Approach to One Digital Health

Abstract This article examines the limitations of principlism in addressing the ethical challenges posed by One Digital Health. While principlism remains influential in bioethics, digital health, and global health policy, we argue that it is insufficient to capture the relational...

Citation accuracy, citation noise, and citation bias: a foundation of citation analysis

Abstract Citation analysis is widely used in research evaluation to assess the impact of scientific papers. These analyses rest on the assumption that citation decisions by authors are accurate, representing the flow of knowledge from cited to citing papers. However, in practice,...

Volcanic textures control the mechanical behaviour of Mesoamerican obsidians

Abstract Obsidian—natural volcanic glass—was exploited for millennia and played a central role in the technological and socio-economic development of pre-Hispanic societies across Mesoamerica. The selection of obsidian from specific deposits has been linked to differences in visu...

Convergent genome streamlining accompanies independent miniaturization in the world’s smallest fishes

Miniaturization, the reduction of adult body size to an extreme degree, has evolved repeatedly across vertebrates. Yet its genomic underpinnings remain poorly understood. Cypriniformes, the most species-rich order of freshwater fishes, contains multiple miniaturized lineages that...

GLP-1 Receptor Agonists in Dentistry: Promise, Pitfalls, and Evidence Gaps

GLP-1RAs (glucagon-like peptide-1 receptor agonists) have become one of the fastest-growing drug classes worldwide, with prescriptions for obesity treatment increasing by 587% from 2019 to 2024. While their metabolic and cardiovascular benefits are well established, the implicati...

A single transcriptional regulator is crucial for the adaptation of Staphylococcus aureus to diverse niches

Adaptation of bacterial pathogens to new hosts often involves the exchange of mobile genetic elements, or generally the highly variable accessory genome. However, adaptation to different niches is often plastic, mediated by conserved pathways in the core genome. The general stres...

Signatures of Band-like Charge Carrier Transport in a Three-Dimensional Fe-HHTP Metal–Organic Framework

Abstract Metal–organic frameworks (MOFs) offer exceptional structural and chemical tunability, and the emergence of electrically conductive variants creates new opportunities for functional optoelectronic materials. Here, we investigate charge transport in a three-dimensional (3D...

Intraoperative OCT-Based Stromal Topography in Phototherapeutic Keratectomy

Objectives: This study aims to investigate whether anterior corneal curvature can be reliably measured by combined Placido–optical coherence tomography (OCT) during phototherapeutic keratectomy (PTK) despite intraoperative stromal swelling, and to quantify the immediate smoothing...

Disease Duration Differentiates Freezing of Gait Response to Subthalamic and Nigral Stimulation for Parkinson's Disease in an Exploratory Multicenter Controlled Trial

BACKGROUND: Freezing of gait (FoG) belongs to most pressing unmet symptoms in the treatment of Parkinson's disease. OBJECTIVES: To explore whether combined subthalamic and nigral (STN + SNr) deep brain stimulation improves FoG compared with optimized STN stimulation alone; to ide...

Multiple discrimination at work and depressive symptoms in young adults

BACKGROUND: We aimed to estimate the implications of cumulative exposure to discrimination at work for mental health among young adults. Our specific objective was to investigate if experiencing multiple types of discrimination at work is associated with depressive symptoms. METH...

An update on neuro-otology and neuro-ophthalmology – focusing on new developments in the last three years

Vertigo, dizziness, and imbalance are among the most frequent presenting symptoms in primary care and in the emergency department (ED). The clinical diagnosis is based on a structured patient history and bedside examination of the vestibular system and the ocular motor system, lo...

Controlled Hydrogen Delivery by Single‐Atom Ru Accelerates Electrocatalytic Ammonia Synthesis

ABSTRACT Electrocatalytic nitric oxide reduction to ammonia (NORR) offers a dual opportunity for NO remediation and decentralized NH 3 production, yet its efficiency is often limited by competing pathways and unclear structure–function relationships. Here we introduce a reactant‐...

Controlled Hydrogen Delivery by Single‐Atom Ru Accelerates Electrocatalytic Ammonia Synthesis

ABSTRACT Electrocatalytic nitric oxide reduction to ammonia (NORR) offers a dual opportunity for NO remediation and decentralized NH 3 production, yet its efficiency is often limited by competing pathways and unclear structure–function relationships. Here we introduce a reactant‐...

In vivo DNA damage protection during cell migration across confining embryonic tissue environments

Abstract Cells migrating through confined spaces can experience nuclear deformation, nuclear envelope damage and DNA lesions, but the physiological consequences of confinement in vivo remain unclear. Using the zebrafish neural crest as a model of developmental migration, we show...

Henry E. Sigerist, (Nazi) Eugenics, and the "Ideal of Prophylaxis".

. Published online ahead of print October 8, 2026:e1-e7. https://doi.org/10.2105/AJPH.2026.308760).

Measuring the Posterior Airway Space: Inaccuracies in Taking and Interpreting Lateral Cephalograms

Abstract Objectives Although lateral cephalograms (LCs) are often used to measure the posterior airway space (PAS), little consensus has been reached on standardised PAS measurement procedures, which hinders reproducibility. This study uses LCs to evaluate the reliability of PAS...

Charge Storage and Dark Photocatalysis in Multivariate Ti‐Based Metal‐Organic Frameworks

ABSTRACT “Dark photocatalysis” decouples electron storage from photoconversion, offering a promising route to buffer solar intermittency, however requiring precise control of light‐matter interactions. Metal–organic frameworks (MOFs) provide a platform to tailor these interaction...