LMU Klinikum

Limit laws for critical dispersion on complete graphs

We consider a synchronous process of particles moving on the vertices of a graph G, introduced by Cooper, McDowell, Radzik, Rivera and Shiraga (Random Structures Algorithms 53 (2018) 561–585). Initially, M particles are placed on a vertex of G. In subsequent time steps, all parti...

High-Resolution Ex Vivo Confocal Microscopy to Distinguish Cutaneous T-Cell Lymphoma from Inflammatory Mimickers

Cutaneous T-cell lymphoma (CTCL) often clinically resembles inflammatory dermatoses such as eczema, making accurate and timely diagnosis challenging. Since early differentiation is critical for appropriate treatment and prognosis, fast and reliable diagnostic tools are needed. Ex...

Allocation of TSPO-PET signals to cellular and extracellular compartments in dependence of blood-brain barrier disruption in experimental glioblastoma

BACKGROUND: Translocator protein (TSPO)-PET imaging facilitates monitoring of glioblastoma in preclinical models and patients. However, specificity of TSPO-PET signals remains to be investigated. In this study, we aimed to decipher exact contributions of cellular and extracellula...

The German S3-level guideline for the diagnosis and management of rare dental disorders

Abstract Objectives The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be pa...

Changing the motivation for mental work with temporal interference stimulation

Successful goal-directed behavior often requires the exertion of effortful control processes. The striatum is thought to play a key role in determining whether a goal is worth the required cognitive effort, but whether and how the striatum causally influences effort-based decisio...

Results of the validated German Perceived Stress Questionnaire (PSQ) from a large German cohort of healthy adults and different disease groups compared to historical reference values

Abstract Background Reference values of the validated German Perceived Stress Questionnaire (PSQ) were published in 2005 for healthy adults and individuals with different clinical conditions. We compared historical values with PSQ from the large German cohort participating in “Ri...

Genome-wide analysis of social behaviour across social domains, reporters and developmental stages: a meta-regression approach

Abstract Social behaviour is a heritable trait linked to well-being and mental health, yet it varies across social context, including social domains, informants and development, which may shape its underlying genomic architecture. Here, we conducted a genome-wide meta-regression...

Evaluation of visual guidance techniques for augmented reality-supported assembly tasks in the medical context

Abstract Handling manual assembly tasks is a crucial part of everyday life. Especially with surgical instruments, proficient handling is critical for flawless workflows, efficiency, and overall patient safety. Markerless object pose estimation and augmented reality (AR) visualiza...

Severe antipsychotic-associated gastrointestinal hypomotility: AMSP pharmacovigilance data from 333,175 psychiatric inpatients

Abstract Background Severe courses of gastrointestinal hypomotility (GIH) are rare but potentially life-threatening adverse drug reactions (ADRs) associated with antipsychotic drugs (APDs). This study aimed to investigate the frequency, clinical characteristics, and associated dr...

The road ahead: How the future of learning is shaped through individual differences

The future of learning is often framed through technological change. Here, we show that these developments do not replace, but emphasize, long-standing questions in educational psychology, concerning why learners benefit differently from the same opportunities, how learning envir...

The series Cs 3+2 n [ M O 4 ]O n ( M = Nb, Ta; n = 1, 2) with isolated tetrahedral oxidometalate anions [ M O 4 ] 3−

Abstract Four new compounds, Cs 5 [ M O 4 ]O and Cs 7 [ M O 4 ]O 2 with M = Nb, Ta were synthesised as serendipitous products from the reaction of Cs 3 O with HgO in Nb or Ta crucibles. They contain tetrahedral [ M O 4 ] 3 − ${\left[\mathit{M}{\text{O}}_{4}\right]}^{3-}$ oxidomet...

Outcomes and adverse events of postoperative stereotactic interventional radiotherapy/brachytherapy for brain metastases: a systematic review

Postoperative radiotherapy is commonly used after resection of brain metastases, but durable local control with a low rate of adverse events (AEs) remains challenging. This systematic review summarizes outcomes and AEs of postoperative stereotactic interventional radiotherapy (S-...

EXPRESS: Detection of Mycoplasma species and respiratory pathogens in cats with rhinitis and healthy cats

Objectives: To investigate the prevalence of Mycoplasma spp. in cats with rhinitis compared to healthy cats and to evaluate factors associated with detection. Methods: A total of 46 cats with rhinitis and 37 asymptomatic controls were prospectively enrolled. Nasal swabs were coll...

Splenic regulation of systemic platelet activation state

Platelets are essential to prevent blood loss and to orchestrate inflammation. Thrombotic complications of vascular disease and hyperresponsive platelets are associated with adverse outcomes, yet physiological mechanisms counteracting systemic platelet activation are poorly defin...

Conditional deep generative modeling of blood-based infrared spectra enables controlled in-silico phenotyping studies

Abstract Infrared molecular fingerprinting of blood offers a scalable, minimally invasive window into human physiology, but limited follow-up, imbalanced cohorts, and restricted access to diverse phenotypes constrain systematic studies. Here, we introduce a conditional deep gener...

How Long and How We Judge Age: A Cross-Racial and Cross-Gender Eye-Tracking Investigation

Abstract Background Facial aging results from genetic, environmental, and lifestyle factors, leading to wrinkles, volume loss, and contour changes. These alterations affect perceived age, attractiveness, and self-image. Eye-tracking technology provides insights into gaze patterns...

Nuclear Factor-κB Signaling in Murine Models of Malignant Pleural Mesothelioma

Background: Malignant pleural mesothelioma (MPM) is an aggressive asbestos-associated cancer in which inflammatory pathways may contribute to tumor behavior. NF-κB signaling is a central mediator of inflammation and cell survival, but the relative contributions of its associated...

Artificial Intelligence in Orthodontics: Part 3—Cautions, Limitations and Future Prospects

ABSTRACT Artificial intelligence (AI) is increasingly affecting orthodontic practice and research, yet its adoption requires a careful understanding of both its capabilities and its limitations. As the final part of a three‐section review, this paper focuses on the practical caut...

Bimekizumab as an Effective Treatment in Darier Disease: Clinical Outcomes of a Single-Center Retrospective Analysis of Patients Treated with Biologics

Darier disease (DD) is a rare autosomal dominant genodermatosis with limited systemic therapeutic options. Retinoids are the gold standard therapy, but long-term application is frequently limited by adverse events. Case reports suggest that biologicals approved for psoriasis vulg...

Association of three different dietary patterns with the metabolomic profiles of children: the BiomarKid project

Abstract Background and aims Metabolomics offers a promising approach to objectively assess food intake and nutrition-related health risks. Three different dietary patterns (DPs) associated with cardiometabolic health were previously identified at 2 years of age in the EU Childho...