LMU Klinikum

Host Response Impairs Tissue Integration of a Fibrin Hydrogel Scaffold Containing Poly(ε-caprolactone) Nanofibers for Peripheral Nerve Repair

The development of bioengineered conduits for the repair of large peripheral nerve defects remains challenging. Here, we introduce a biomimetic fibrin hydrogel scaffold containing stacked arrays of aligned poly(ε-caprolactone) (PCL) nanofibers that mimics the naturally forming fi...

Auricular Reconstruction Following Traumatic Amputation: A Historical Review and Contemporary Treatment Algorithm

Background: Traumatic auricular amputation represents a rare but complex reconstructive challenge, and numerous surgical techniques have been developed over the past century to optimize functional and aesthetic outcomes. This historical review examines current auricular reattachm...

Procedure-related uptake on CXCR4 PET/CT: a frequent pitfall independent of time and anatomical site

Abstract Introduction As a pan-tumor tracer, chemokine receptor 4 (CXCR4)-directed [ 68 Ga]Ga-PentixaFor is frequently utilized in patients with hematological malignancies. We aimed to evaluate the impact of recent surgical and interventional procedures on uptake. Methods Patient...

Non-invasive sampling reveals distinct HPV and immune signatures associated with abnormal cytology in people living with HIV

Abstract Persistent high-risk HPV infections drive most anal cancers, disproportionately affecting people with HIV (PLH), for whom cytology-based screening remains essential. However, the biological context of abnormal anal cytology, particular regarding local immune cells, is in...

Why are most people more creative than others? Exploring the better-than-average effect in creativity

People tend to rate themselves as more creative than average, but how this better-than-average effect (BTAE) generalizes across creativity aspects and which individual differences predict it remains unclear. In two online studies (N = 700), participants evaluated themselves relat...

PSMA PET/CT-guided salvage elective nodal radiotherapy for nodal metastases after radical prostatectomy: a bi-institutional long-term outcome analysis

PURPOSE: PSMA PET/CT has transformed the detection of nodal recurrence after radical prostatectomy, yet real-world evidence on long-term outcomes of PSMA PET/CT-guided salvage elective nodal radiotherapy (ENRT) remains limited. This study evaluated oncological outcomes of PSMA PE...

Sexual Health in Psychiatry: Bridging the Communication Gap and Training Needs between Patients and Clinicians – A Cross-Sectional Exploratory Pilot Study

Sexual health is integral to mental well-being, yet it remains under-addressed in psychiatric care. Mental disorders and psychotropic medications can cause sexual dysfunctions. Despite its clinical relevance, sexual health is often not routinely assessed or discussed in psychiatr...

Threat and Remedy: AI’s Technological and Normative Role in Democratic Discourse and Counter Speech

Artificial intelligence (AI) has fundamentally transformed online discourse, serving simultaneously as a source of and a potential solution to threats to democracy. This article conceptually examines AI’s multifaceted role in digital public spheres, beginning with an analysis of...

Resolving the Performance Feedback Puzzle: CEO Psychopathy, Heterogeneous Emotional Responses to Aspiration Gaps, and Risk-Taking

Theoretical perspectives provide conflicting predictions regarding how firms adjust risk-taking in response to performance–aspiration gaps. The behavioral theory of the firm attributes increased risk-taking to problemistic search under negative gaps, whereas threat–rigidity theor...

Change in COVID-19 outcomes in lymphoma patients across pandemic waves: results of the COVID-19-lymphoma registry of the Bavarian Cancer Research Center (BZKF) 2020–2022

Abstract Patients with malignant lymphomas are at increased risk for severe COVID-19. In the general population, outcomes of COVID-19 have improved dramatically over time due to increasing immunity through vaccination or infection and due to improved clinical care. It is unclear...

Brugada Syndrome in the Pediatric Population: Diagnostic Challenges and Clinical Outcome—Results of the German Multicenter Study COGIA

ABSTRACT Introduction Diagnosis and treatment of children and adolescents with suspected Brugada syndrome (BrS) is challenging. Aim of the study was to evaluate the applicability of current diagnostic criteria for pediatric patients with suspected BrS in the German multicenter st...

Tricuspid-Valve Intervention in Heart Failure

BackgroundThe effect of transcatheter tricuspid-valve repair on clinical outcomes, including death and hospitalization for heart failure, in patients with severe tricuspid regurgitation remains uncertain. MethodsWe randomly assigned patients with symptomatic severe tricuspid regu...

Robotic-assisted compartmental dissection for retroperitoneal sarcoma: a feasibility study on cadavers with the da Vinci Xi system

Abstract Purpose Retroperitoneal sarcomas (RPS) pose major technical challenges because of their size, anatomical complexity, and need for multivisceral resection. We evaluated the feasibility of a standardized robotic approach for right- and left-sided retroperitoneal sarcoma (R...

Locomotion optimizes sensory representations through a computational principle shared by rodents and primates

Behavior modulates the activity of sensory systems in multiple ways: from gain changes in individual neurons to changing interactions in neural populations. These effects are not universal; while movement has a strong influence on sensory coding in rodents, its impact on primates...

Could NQO1 genotypes impact the results of clinical trials with idebenone?

Carelli et al. argue that new insights into how NQO1 influences the response to idebenone warrant reevaluating the results of previous clinical trials, including those in Friedreich ataxia and Duchenne muscular dystrophy, using patient stratification by NQO1 genotype.

Dual apical methyltransferases orchestrate motility initiation in apicomplexan parasites

Abstract Apicomplexan parasites such as Toxoplasma gondii initiate motility through rapid, spatially confined cytoskeletal activation at their apical end. While calcium-, lipid-, and kinase-based signalling pathways have been partially elucidated, how these cues are translated in...

A comparison of body image components, including attentional bias and body appraisal, in adolescents with anorexia nervosa or depression, and non-clinical controls

Abstract Background Body image disturbance (BID) is increasingly recognized as a transdiagnostic factor. Beyond its established role in anorexia nervosa (AN), specific components of BID are also associated with the development and maintenance of psychopathology in adolescent Majo...

Vaccine preparedness for Bundibugyo virus and lessons learned

The ongoing 2026 outbreak of Bundibugyo virus (BDBV) in the Democratic Republic of the Congo and Uganda is the largest so far on record. Despite experience from previous Ebolavirus outbreaks, the current lack of vaccines against BDBV underscores a recurring failure in proactive p...

Assessment of the effectiveness of protein in critical illness: the role of statistical shortcomings in explaining discrepancies between observational studies and randomized controlled trials

Until 2023, recommendations for prescribing protein to critically ill patients were largely based on observational studies and non-randomized interventions. Several large, multicentre non-randomized studies of intervention conducted between 2009 and 2017 consistently reported tha...

Modulation of neuronal excitability and plasticity by BHLHE41 conveys lithium non-responsiveness

Abstract Many bipolar disorder (BD) patients are non-responsive to lithium. The mechanisms underlying lithium (non-)responsiveness are largely unknown. By using gene-set enrichment analysis methods, we found that core clock gene-sets are significantly associated with lithium resp...