Kobe University

Exploring vertical genomic heterogeneity and chemotherapy response using targeted genomic sequencing in muscle-invasive bladder cancer

We performed a targeted genomic sequence of muscle-invasive bladder cancer (MIBC) tissues to investigate vertical intratumoral heterogeneity, invasion processes, and potential biomarkers of platinum-based neoadjuvant chemotherapy (NAC) efficacy in MIBC. Mutations in key genes tho...

Engineering a Highly meta -Selective Biphenyl Monooxygenase for the Biosynthesis of High-Value Polymer Precursors

Abstract The meta-selective C–H functionalization of aromatic substrates lacking meta-directing electron-withdrawing groups remains challenging. To engineer the regioselective enzymatic conversion of biphenyl (BP) to 3,3′-dihydroxybiphenyl (33DHBP), an industrial precursor to hig...