Kobe University

Age-Related Differences in Surgical Management of Giant Cell Tumor of Bone: A Nationwide Registry Analysis

Background: Giant cell tumor of bone (GCTB) rarely affects elderly individuals, and its clinical characteristics in this population remain insufficiently defined. This study aimed to investigate epidemiologic features and age-related differences in the surgical management of GCTB...

The fitness landscape of a form II rubisco in a photosynthetic bacterium guides engineering of oxygen tolerance

Abstract Rubisco is an important but challenging protein engineering target. Fast and selective rubiscos could enhance photosynthesis in plants and accelerate biobased production processes. To facilitate engineering of rubisco, we applied an in vivo screen that couples rubisco ac...

Comparative effectiveness of three treatment strategies for submacular hemorrhage secondary to age-related macular degeneration

Abstract We aimed to compare the effectiveness of three treatment strategies for extensive submacular hemorrhage (SMH) secondary to age-related macular degeneration (AMD): intravitreal anti-vascular endothelial growth factor (VEGF) monotherapy, anti-VEGF combined with sulfur hexa...

Beyond the machine: risk, fear, optimism and the foundations of public trust in AI

Abstract What drives public trust in artificial intelligence (AI)? This study examines the individual and institutional foundations of AI trust across two contrasting democracies: Japan and the United Kingdom. Drawing on original survey data ( N = 3235), we test a set of hypothes...

Where planetary solids survive sublimation around young and hot white dwarfs

Abstract All observed planetary systems orbiting single white dwarfs have lived through the hot stellar transition from an asymptotic giant branch star. In this post-nebular transition period, the initial conditions for planetary system evolution throughout white dwarf cooling ar...

Data Informativity for Stabilization of Discrete-Time Infinite-Dimensional Systems

Abstract. This paper develops a framework for data-driven stabilization of discrete-time infinite-dimensional systems. We investigate informativity for stabilization, defined as the existence of a state-feedback gain that stabilizes all systems consistent with the available input...

Heterozygous COL4A3/COL4A4 variants: diagnostic trends and clinical kidney outcomes

Abstract Background Heterozygous pathogenic variants in COL4A3 or COL4A4 are relatively common and associated with a broad clinical spectrum. However, nomenclature and risk stratification remain unsettled. We aimed to investigate temporal diagnostic trends and clinical features o...

New evidence on the 1919 FA silver cup: a forgotten chapter in Japanese football history

The Japan Football Association (JFA) was founded in 1921, following the donation of a silver cup by the Football Association (FA) in 1919. This trophy became the centerpiece of a tournament that later evolved into the prestigious Emperor's Cup. While the conventional narrative at...

Fatty acid signatures distinguish autotrophy, partial mycoheterotrophy, and full mycoheterotrophy in angiosperms

Abstract Detecting partial mycoheterotrophy in green plants remains challenging, particularly in associations with arbuscular mycorrhizal (AM) or rhizoctonia fungi, because natural-abundance stable isotope patterns often provide limited diagnostic resolution in these systems. We...

Aspirin Omission at the Time of Primary Percutaneous Coronary Intervention in STEMI

BackgroundThe safety of omitting up-front treatment with aspirin during primary percutaneous coronary intervention (PCI) in patients with ST-segment elevation myocardial infarction (STEMI) remains unclear. MethodsWe conducted a multicenter, open-label, randomized trial in Japan i...

Awareness, knowledge, and utilization of Japanese physical activity guidelines among health fitness programmers in Japan

We conducted an anonymous online survey to clarify awareness, knowledge, and utilization of Japanese physical activity (PA) guidelines among certified Health Fitness Programmers who are specialists in exercise guidance for health promotion. Responses were obtained from 415 partic...

Circadian temperature compensation is intrinsically linked with metabolism and redox signaling

Abstract Circadian rhythms are a universal property of organisms, and a defining property of these oscillators is the ability to maintain a precise period at different temperatures. Indeed, the discovery in the 1950s of this property, known as “temperature compensation,” was a wa...

Response to the Letter Regarding “Methodological Considerations in Real‐World Evaluation of Durvalumab Plus Tremelimumab for Unresectable Hepatocellular Carcinoma”

Data supporting the findings of this study are available from the corresponding author upon reasonable request, subject to institutional review board approval and execution of appropriate data sharing agreements.

Gendered cultural discourse in Japan across the prewar–postwar transition: evidence from historical word embeddings

Abstract We quantify the evolution of gender stereotypes in Japan from 1900 to 1998, covering the prewar–postwar transition, using a series of yearly word embeddings trained on historical text corpora. We define the gender stereotype value to measure the strength of a word’s gend...

Association Between PS-OCT Derived Polarimetric Entropy and RPE Cellular Metrics Measured With Adaptive Optics Imaging in Retinitis Pigmentosa

Purpose: The purpose of this study was to investigate the association between entropy values derived from the retinal pigment epithelium (RPE) layer using polarization-sensitive optical coherence tomography (PS-OCT) and RPE cellular metrics obtained by adaptive optics transsclera...

Clinical and molecular characteristics of thalamic gliomas in adults: prognostic impact of TERT promoter mutation

BACKGROUND: Adult thalamic gliomas (ATGs) are rare and biologically heterogeneous tumors. Although the 2021 World Health Organization (WHO) classification designates all diffuse midline gliomas (DMGs), H3-altered, as grade 4, accumulating evidence suggests that adult thalamic DMG...

Associations between jump-derived mechanical indicators and sprint performance across sprint sections in baseball players

The purpose of this study was to examine the relationships between sprint performance across discrete distance sections and mechanical indicators derived from ballistic and reactive jumping tasks in male collegiate baseball players. Sixty-two players performed maximal 40-m sprint...

A multidimensional analysis of CGM-derived glucose metrics in type 1 diabetes: differential associations of insulin degludec and insulin glargine U300

Ultra-long-acting basal insulins, insulin degludec (IDeg) and insulin glargine U300 (IGlarU300), are widely used in type 1 diabetes mellitus (T1DM), but their differential effects on multidimensional continuous glucose monitoring (CGM) profiles remain unclear. We aimed to identif...

Modeling user redemption behavior in complex digital incentive environment: an empirical study using large-scale transactional data

Abstract The digital economy implements complex incentive systems to retain users through point redemption. Understanding user behavior in such complex incentive structures presents a fundamental challenge, especially in estimating the value of these digital assets against tradit...

Genetic characterizations and seroprevalence of hepatitis B virus among non-human primates and human caretakers in Indonesia

Hepatitis B virus (HBV) is a major human pathogen also detected in non-human primates (NHPs), yet its cross-species and zoonotic transmission potential remains poorly defined. We screened 237 NHPs across 10 species together with 65 human caretakers from four major Indonesian isla...