Kobe University

A collaborative study evaluating the detection of virus-infected cells by transcriptomic high-throughput sequencing

High-throughput sequencing (HTS) is an agnostic virus detection technology that can replace or supplement the conventional adventitious virus assays used for safety testing of biologics. Transcriptomic HTS is particularly suitable for the detection of replicating viruses. We have...

Analytical and experimental investigation of the axial compressive behaviour of recycled brick-concrete aggregate CFST

The mixture of recycled concrete aggregate (RCA) and recycled brick aggregate (RBA) is named as recycled brick-concrete aggregate (RBCA). Filling RBCA concrete into steel tubes to form RBCA concrete-filled steel tube (RBCA-CFST) not only enhances the mechanical properties of the...

Development of a python interface for a framework of cross-reference solar-terrestrial physics simulation

Cross-reference simulation combines multiple simulation codes when one code requires data produced by another. To provide an efficient and convenient solution for cross-reference Solar-Terrestrial Physics (STP) simulation, a framework called Code-To-Code Adapter (CoToCoA) Library...

Thalamic projections from the cerebellar nuclei receiving proprioceptive signals from the jaw muscles in rats

The neural mechanisms involved in transmission of proprioceptive information from muscles are not fully understood. Proprioceptive signals from jaw-closing muscle spindles (jcms) are relayed to the supratrigeminal nucleus (Su5), and, then, from the Su5 to the thalamus including t...

Ultrahigh flow strength in shocked nanopolycrystalline diamond

Extreme pressures and temperatures create conditions that allow even hard and brittle materials to flow plastically. Despite extensive research, the limits of flow strength under such conditions remain uncertain, and the mechanisms driving deformation at the relevant stresses are...

The Forgotten Joint Score Shows High Correlation With Established Anterior Cruciate Ligament Reconstruction Patient‐Reported Outcome Measures While Capturing Joint Awareness and Functional Recovery: A Systematic Review

PURPOSE: To systematically review and analyze the existing literature on the use of the Forgotten Joint Score-12 (FJS-12) in patients undergoing anterior cruciate ligament reconstruction (ACLR), with the aim of evaluating its effectiveness as a complementary tool to traditional p...

Taxonomic study of the family Pedicellasteridae (Asteroidea: Forcipulatida) from Japanese waters, with descriptions of two new species and one new record

Two new deep-sea species of the family Pedicellasteridae from Japanese waters – Ampheraster phantasma sp. n. and Anteliaster seisuiae sp. n. – are described. These new species represent the first discovery of the genera Ampheraster and Anteliaster from this region. We also report...

Energy offsets between the Er 3+ 4 f -states and the GaAs energy levels important for photon ratchet intermediate-band solar cells

The lifetime of the carriers present in the intermediate bands is short, and thus an additional band at slightly lower energies is introduced in photon ratchet intermediate-band solar cells to reduce the impact of the intermediate-band lifetime. This so-called ratchet band should...

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations

Abstract Large-scale genome sequencing analyses have identified driver gene mutations (DGMs) in most cancers as well as their associated tumorigenic mechanisms. However, a small fraction of cancers are not positive for these canonical DGMs, leaving the mechanisms underpinning the...

Association Between Acute-Phase Occupational Therapy and Quality of Life at Hospital Discharge and 90 Days After Discharge

Background/Objectives: Early rehabilitation in critically ill patients has been associated with improved physical outcomes. However, evidence regarding the association between occupational therapy and quality of life (QOL) remains limited. This study examined the association betw...

Can Chemoradiotherapy Expand Immune Checkpoint Blockade Responsiveness in Mismatch Repair‐Proficient Rectal Cancer?

ABSTRACT Immune checkpoint blockade (ICB) has transformed the treatment of mismatch repair‐deficient (dMMR) colorectal cancer but produces no meaningful benefit in advanced mismatch repair‐proficient (pMMR) disease. In the neoadjuvant setting, however, pathological responses have...

Functional Heterogeneity of Fusobacterium nucleatum Subspecies in the Immune Microenvironment of Oral Squamous Cell Carcinoma

Oral squamous cell carcinoma (OSCC) develops through multiple pathogenic and environmental factors. Increasing evidence suggests that the oral microbiota, particularly intratumoral bacteria, is also associated with OSCC progression; however, the relationship between individual ba...

Effects of Financial Innovation on the Demand for Money: Evidence from Bangladesh

Empirical analyses of the money demand function in Bangladesh typically consider only income level and the interest rate. This study estimates the traditional money demand function alongside extended models incorporating financial innovation and the exchange rate for comparative...

A multicenter phase II trial of ramucirumab plus irinotecan for early recurrence of gastric cancer during or after adjuvant chemotherapy with docetaxel plus S-1 therapy: the RAMIEL trial (OGSG1901)

Abstract Background There is currently no established chemotherapy regimen for early recurrence of pathological stage III gastric cancer (GC) following adjuvant chemotherapy with docetaxel plus S-1 (DS) after D2 gastrectomy. We aimed to evaluate the efficacy and safety of ramucir...

Glutathione acts as an exometabolite that promotes growth recovery in fission yeast with defects in amino acid metabolism and cell polarity

ABSTRACT Microorganisms in nature form communities through diverse interactions, such as mutualism and competition, to adapt to their ecological environments. These interactions seem to be mediated by extracellular metabolites (exometabolites), yet the chemical and biological div...

Intravitreal Onchocerca sp. With Concomitant Cerebral MRI Lesion: A Case Report.

BACKGROUND Onchocerca lupi is a zoonotic filarial nematode that primarily infects canids. Human infection is rare and typically involves the eye or subcutaneous tissue. O. lupi infection should be considered in cases of unresolved uveitis or neurological symptoms. We report a dia...

Management and Outcomes of Cardiac Sarcoidosis: Insights From the Nationwide MYSTICS Registry

BACKGROUND: Cardiac sarcoidosis (CS) may lead to serious outcomes, but large-scale data are lacking because of its rarity, diagnostic uncertainty, and heterogeneous clinical presentations. Actual management and outcomes, including recurrence, are not well understood. This study a...

Photo‐Switchable Molecular Module Programming PET Biodegradation in Aquatic Environments

ABSTRACT Plastics face a durability paradox where their utility causes environmental intractability. We resolve this by embedding a photo‐controlled molecular module, a pyrrolidone carboxylamide derived from itaconic acid, directly into the polymer backbone. While stable during u...

Whole exome sequencing and transcript analysis of a PTEN splice-site variant in a child with PTEN hamartoma tumor syndrome: a case report

Introduction PTEN hamartoma tumor syndrome (PHTS) is a hereditary tumor syndrome characterized by macrocephaly, neurodevelopmental disorders, mucocutaneous lesions, and predisposition to tumors. In childhood, the characteristic mucocutaneous and tumor-related manifestations may n...

Harm Reduction-Oriented Occupational Therapy for Substance Use Disorders: A Retrospective Cohort Study

ImportanceIdentifying factors associated with sustained engagement in harm reduction-oriented occupational therapy may help inform more accessible interventions for individuals with substance use disorders (SUDs).ObjectiveTo examine participant characteristics associated with sus...