Johns Hopkins University

Distributed burst firing mediates optimized cortical encoding of natural self-motion

Accurate perception of self-motion requires that vestibular input be transformed into neural representations suitable for integrating multisensory cues to guide action. Here, we demonstrate that vestibular cortical neurons represent the self-motion stimuli encountered during ever...

Challenges and needs of people living with diabetes in self-management in Ethiopia: A qualitative exploration

Abstract Background Diabetes is unique due to its cross-cutting nature, impacting multiple organ systems and increasing the risk for other communicable and non-communicable diseases if not managed properly. Managing diabetes involves frequent blood glucose measurement, medication...

Addressing Medical Neglect in Children With Complex Chronic Conditions

In this issue of Pediatrics, Cleveland et al report a cross-sectional analysis of a 2-state, multiyear database of linked child protective services (CPS) and Medicaid claims data to characterize the prevalence and associations of complex chronic condition (CCC) status across CPS...

Association between self-reported oral health issues and autoimmune diseases: evidence from UK biobank

Oral microbiome dysbiosis may contribute to autoimmune disease development, but epidemiological evidence linking oral health and autoimmune disease risk is limited. To evaluate the association between self-reported oral health issues by questionnaire—defined as the presence of pa...

Duration of Therapeutic Hypothermia After Out-of-Hospital Cardiac Arrest

Importance Therapeutic hypothermia is widely used for neuroprotection following cardiac arrest, but clinical trials have not consistently demonstrated improved neurological outcomes, and the optimal duration of cooling remains uncertain. Objective To determine the duration of the...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Identificationof the Site of the Fe–S Clusterin CPSF30 via Metal-Coupled Oxidation-Mass Spectrometry

Abstract Cleavage and polyadenylation specificity factor 30 (CPSF30) is a zinc finger protein that plays a key role in pre-mRNA processing by recognizing specific AU-rich sequence elements to facilitate polyadenylation. CPSF30 contains five highly conserved domains made up of thr...

Going with the flow to solve for symmetry-driven PDE dynamics with physics-informed neural networks

We address a computational framework that integrates symmetry reduction into Physics-Informed Neural Networks (PINNs) for analysing symmetry-driven dynamics in nonlinear partial differential equations (PDEs). Using an auxiliary network to learn time-dependent transformations, we...

Integrative multiomic analysis identifies transcription factors and target proteins in renal cell carcinoma

Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...

Local Sustained Delivery of Temozolomide via an Injectable Poly(Anhydride-Ester) Depot for Glioblastoma Therapy

Background/Objectives: Glioblastoma (GBM) remains one of the most aggressive primary brain malignancies, with limited therapeutic progress over the past two decades. Systemic administration of temozolomide (TMZ) is a pillar of clinical management but is constrained by poor brain...

Reproducibility of Volumetric Analysis using Ultra-Low-Field Portable Magnetic Resonance Imaging

Brain volume change over time is an important imaging-based biomarker of disease. However, traditional MR scanners are associated with high direct and indirect costs both up front and over time, rendering them inaccessible to many around the world. Recently, ultra-low-field (64 m...

Structurally competent care for families facing the continuous traumatic stress of community violence and systemic racism

Abstract In racially and economically segregated communities, structural violence and chronic adversity perpetuate the risk for community violence and related trauma exposure. Despite widespread awareness of community violence, urban youth of color are among those least likely to...

Infertility service availability, geographic accessibility, and use: results from linked facility-female cross-sectional data in Burkina Faso, Côte d’Ivoire, Niger, and Uganda

Abstract Background Infertility affects millions of people globally, with the highest prevalence in Africa (16%). Despite strong evidence linking sexually transmitted infections (STIs) to infertility in sub-Saharan Africa, evidence on the availability of and accessibility to infe...

Congenital heart disease in pregnancy and severe maternal morbidity: A distributed data network study

Abstract Introduction Pregnant people with congenital heart disease (CHD) are a growing patient population in obstetrics, yet evidence on the risk for severe maternal morbidity (SMM) has largely been limited to studies that lack specificity for CHD. We conducted this study to dem...

How Equity and Quality Are Considered by Cancer Centers Offering Practice-Integrated Telehealth Visits: A Qualitative Study

INTRODUCTION: The COVID-19 pandemic forever changed health care delivery and led to a rapid uptake in telehealth visits. However, the quality and equity of these visits compared to in-person visits are unknown. This analysis interviewed oncology practitioners to understand how US...

Racial microaggressions in prenatal care settings and perceived quality of prenatal care among Black/African American women

In the United States, Black/African American (AA) women face significant health disparities, including higher rates of Adverse Pregnancy Outcomes (APOs). This is despite increased utilization of prenatal care (PNC) over time, which is a critical intervention for identifying and m...

Multiple micronutrient supplements (MMS) for adolescent girls: are we getting carried away by the hype?

Multiple micronutrient supplements (MMS) during pregnancy have gained attention in recent years due to growing evidence that they are more effective than iron and folic acid (IFA) supplements in preventing preterm birth and low birth weight. So, should MMS also replace weekly iro...

Ruling In and Ruling Out Sepsis Using Likelihood Ratios of a Host Response Assay

Overview: SeptiCyte RAPID is an FDA-cleared gene expression test that quantifies host immune response to aid in the diagnosis of sepsis. The test yields a score (the SeptiScore) ranging from 0–15, distributed across four bands (1–4) based on increased likelihood of sepsis. Each b...

Real-World Safety and Efficacy of Middle Meningeal Artery Embolization for Chronic Subdural Hematoma: A Retrospective Cohort Study of 38 049 Patients

BACKGROUND: Chronic subdural hematoma is a complex but commonly treated neurosurgical condition, particularly affecting the elderly. Traditional treatment involves open surgeries, but middle meningeal artery embolization (MMAE) has emerged as an effective, minimally invasive adju...

Diagnostic Value of Multiplane Tool in Virtual Lesion Confirmation in Augmented Fluoroscopy-Guided Navigational Bronchoscopy for Peripheral Pulmonary Lesions

BACKGROUND: The demand for minimally invasive diagnostic techniques for peripheral pulmonary lesions (PPL) is rising. Augmented fluoroscopy (AF) provides real-time guidance by overlaying CT-derived virtual targets onto fluoroscopic images, yet its diagnostic value remains poorly...