Izmir University

MRI-derived lumbosacral cerebrospinal fluid volume influences both the extent and persistence of spinal anesthesia: a prospective observational study

Considerable interindividual variability exists in the spread and duration of spinal anesthesia despite standardized anesthetic techniques. Lumbosacral cerebrospinal fluid (CSF) volume has been proposed as an important anatomical determinant of neuraxial block characteristics. Ho...

Single‐stage regenerative approach for persistent RT3 gingival recession following orthodontic improvement of tooth position

Abstract Background Management of gingival recession type 3 (RT3) defects remains a clinical challenge due to interproximal attachment loss and soft tissue deficiency. This case report describes a regenerative strategy for a malpositioned anterior tooth presenting with severe rec...

Study Clinical Characteristics and Outcomes of Candida auris Candidemia in Adult Intensive Care Unit Patients: A 30-Month Retrospective Study

Background: Candida auris (C. auris) has emerged as a multidrug-resistant fungal pathogen causing healthcare-associated outbreaks worldwide, particularly in intensive care units (ICUs). Its environmental persistence, multidrug resistance, and high mortality make it a major challe...

Prediction of pediatric lower urinary tract dysfunction using uroflowmetry data and machine learning with explainable AI techniques

<title>Abstract</title> Purpose To develop and evaluate a machine learning based approach for the interpretation of uroflowmetry in pediatric lower urinary tract dysfunction, aiming to reduce interobserver variability and improve diagnostic consistency while maintaining clinical...

Real-Time Webcam-Based Eye Tracking for AI-Assisted Reading Analysis in Web Environments

This study investigates real-time, webcam-based eye tracking as a low-cost and scalable alternative for AI-assisted reading analysis in web environments, aiming to address the limitations of hardware-dependent eye tracking systems highlighted in existing literature. The proposed...

Epigenetic reprogramming of lineage switching in cancer

Lineage plasticity develops as tumor cells overcome terminal differentiation barriers, adapt to environmental stressors, and acquire metastatic, therapy-resistant phenotypes. These phenotypic transitions are driven by nonmutational epigenetic mechanisms, including dynamic shifts...

Endoscopically assisted decompression in cubital tunnel syndrome: clinical and electrophysiological evaluation

Aim: Endoscopic decompression has become an increasingly popular technique for cubital tunnel syndrome in recent years. This study aimed to report the clinical and electrophysiological outcomes of patients treated with the endoscopy-assisted decompression technique for cubital tu...

Neuromarketing and artificial intelligence: innovative approaches to customer experience management from a firm perspective

Abstract The integration of advanced technologies has transformed marketing practices, making the roles of artificial intelligence and neuromarketing increasingly relevant to customer experience management. The aim of this study is to systematically conceptualize the interaction...

The Limits of Comorbidity Indices in TAVI: How Aggregation Dilutes the Prognostic Power of Individual Biomarkers

Objective. Heart-team decisions in transcatheter aortic valve implantation (TAVI) lean on EuroSCORE II, yet the comorbidity burden that often drives the final choice is rarely scored. We tested a specific two-part hypothesis: whether formally quantifying comorbidity burden (via t...

Comparison of modified thoracoabdominal nerve block via perichondrial approach with serratus intercostal plane block and rectus sheath block combination in laparoscopic cholecystectomy: a randomized controlled trial

Patients undergoing laparoscopic cholecystectomy (LC) may experience severe postoperative pain. Peripheral nerve blocks, as a component of multimodal analgesia, are now widely employed in postoperative pain management. This study investigated the effects of modified thoracoabdomi...

Quality of Life Outcomes in Patients with Pulmonary Hypertension Receiving Prostacyclin Therapy: Impact of Anxiety, Depression, Sociodemographic Characteristics, and Treatment-Related Factors

OBJECTIVE: Despite advances in prostacyclin therapy, pulmonary hypertension (PH) continues to impair patients' quality of life (QoL). This study aimed to identify the clinical and psychological factors associated with QoL in patients receiving prostacyclin therapy. METHOD: This c...

On-Table Versus Deferred Extubation After Paediatric Cardiac Catheterisation Under General Anaesthesia: A Retrospective Cohort Study

Purpose: Extubation timing after paediatric cardiac catheterisation under general anaesthesia remains a challenging clinical decision, particularly in children with cyanotic or haemodynamically significant congenital heart disease. This study aimed to evaluate factors associated...

A novel single‐suture cesarean uterine closure technique to prevent bleeding, resuturing and isthmocele: A three‐year follow‐up retrospective matched cohort study

OBJECTIVE: The aim of this study was to (i) describe a new single layer continuous unlocked uterine incision closure technique during cesarean delivery (Yilmaz technique) and (ii) compare it with the commonly used single layer continuous locked suture technique regarding isthmoce...

How reliable is percutaneous transforaminal endoscopic discectomy during the learning curve? A comparison of outcomes with microsurgical discectomy experiences

We aimed to share our early experience with percutaneous transforaminal endoscopic discectomy (PTED) during the initial phase of the learning curve and to compare its clinical and perioperative outcomes with microsurgical discectomy (MD) in selected patients with symptomatic lumb...

Can passive visual education improve male breast cancer awareness among male nurses? A quasi experimental study

Male breast cancer (MBC) is a rare disease that is frequently diagnosed at advanced stages because of limited awareness among both the general population and healthcare professionals. Despite nurses’ essential role in health education and early detection, evidence regarding inter...

Development and Internal Evaluation of an Integrated Patient–Embryo–Endometrial Scoring System for Predicting Biochemical Pregnancy in IVF: A Proof-of-Concept Pilot Study

Background/Objectives: Implantation in in vitro fertilization (IVF) depends jointly on patient prognosis, embryo quality and endometrial receptivity, yet these are usually assessed in isolation. We developed and internally evaluated, as a proof of concept, an index combining all...

A Novel Piezoelectric Tip for Dorsal Hump Resection: A Randomized Clinical Trial in Primary Open Septorhinoplasty

Objective: To compare the performance of a novel piezoelectric tip with that of a conventional tip for dorsal hump resection in primary open septorhinoplasty, with the hypothesis that the new design would shorten resection time without increasing postoperative edema, ecchymosis,...

A study on iNOS, eNOS, and CD71 expression in preeclampsia: findings shedding light on possible gaps in the current understanding of pathogenesis

Preeclampsia is a multisystem disorder associated with significant maternal and fetal morbidity, yet its underlying mechanisms remain incompletely understood. Oxidative stress is believed to play a central role in its pathophysiology. This study aimed to investigate the relations...

Experimental research: biomechanical evaluation of iliosacral screw fixation effects on sacral and iliac screw strain in lumbosacral and lumbopelvic constructs

Background: The biomechanical impact of iliosacral screw fixation (ISF) on lumbosacral fixation (LSF) and lumbopelvic fixation (LPF) constructs remains unclear. This study evaluates the effects of ISF on screw strain distribution and construct stability in these fixation models....

Blood Pressure and Angina-Related Health Status During Benidipine Therapy: A Multicenter Real-World Cohort Study

Background: Benidipine is a long-acting calcium channel blocker used for the treatment of hypertension and chronic coronary syndrome. Although it effectively lowers blood pressure (BP), the relationship between BP reduction and improvement in angina-related health status during b...