Parameters predicting mortality in antifibrotic-treated IPF patients: mMRC, CPI, TLCO, FVC, GAP

Abstract

BACKGROUND: Idiopathic pulmonary fibrosis(IPF) continues to be a fatal disease despite the use of antifibrotic therapy. There is limited data on the prognostic importance of parameters predicting mortality. We aimed to identify independent mortality predictors in antifibrotic-treated IPF patients. METHODS: With ethics committee approval, IPF patients receiving consecutively antifibrotic treatment between 1 January 2013-01.01.2023 at Izmir Dr Suat Seren Chest Disease and Surgery Training and Research Hospital were retrospectively screened. The clinical-demographic-radiologic data were recorded. Cox regression and Kaplan-Meier analyses explored associations with mortality; receiver-operating-characteristic (ROC) curves defined optimal cutoffs. RESULTS: = 0.048). CONCLUSION: Patients with symptom progression, mMRC >2, presence of honeycombing on radiological imaging, FVC ≤71%, and CPI >49.2 have a higher risk of mortality and should be referred for pulmonary rehabilitation and lung transplantation evaluation at an early stage.