Izmir University

Biliary Duct Invasion in Colorectal Liver Metastases: Prevalence and Clinicopathologic Correlation in a Retrospective Cohort Study

Biliary duct invasion (BDI) is an underrecognized growth pattern of colorectal cancer (CRC) liver metastases that can mimic intrahepatic cholangiocarcinoma or intraductal papillary neoplasm of the bile duct. Its prevalence and clinicopathologic associations remain unclear. This s...

Genotype–cognitive phenotype associations in Duchenne muscular dystrophy: the role of mutation location and ambulatory status in a pediatric cohort

Duchenne muscular dystrophy (DMD) is characterized by progressive motor decline as well as cognitive impairment and reduced quality of life. This study aimed to investigate the relationship between genotype, cognitive functioning, and quality of life in children with DMD. This cr...

Epidural Electrical Stimulation Within an Integrated Rehabilitation Pathway for Traumatic Cervical Spinal Cord Injury: Safety and 12-Month Functional Outcomes

Background/Objectives: Epidural electrical stimulation (EES) is an investigational, off-label neuromodulation strategy used adjunctively with rehabilitation in chronic spinal cord injury (SCI), but safety and longitudinal functional data specific to traumatic cervical SCI remain...

Potentiation of curcumin-mediated antimicrobial photodynamic therapy by sub-inhibitory concentrations of essential oils

Abstract Antimicrobial photodynamic therapy (aPDT) is an emerging alternative to conventional antimicrobials; however, its efficacy against Gram-negative bacteria with complex membrane structures remains limited. In this study, we investigated the ability of essential oils to pot...

Pediatric DOCK8 Deficiency Beyond Infections and Atopy: An Immunoactinopathy with Immune Dysregulation and Multisystem Involvement

Background/Objectives: Dedicator of cytokinesis 8 (DOCK8) deficiency is an autosomal recessive combined immunodeficiency and an actin cytoskeleton-related inborn error of immunity characterized by severe atopy, recurrent infections, and broad immune dysregulation. We aimed to des...

Aspiration-induced orthotopic lung cancer model: a non-invasive method for in vivo tumor microenvironment studies

Background Solid tumors account for the majority of cancer-associated morbidity, and the tumor microenvironment (TME) is a critical determinant of therapeutic response. However, the limited availability of optimized preclinical orthotopic cancer models that allow investigation of...

Beyond body mass index: prevalence of normal weight obesity in a primary care population in Turkey

Obesity is a chronic, recurrent, and progressive disease that impairs health due to abnormal accumulation of adipose tissue. One of the most commonly used methods for the assessment of obesity is the Body Mass Index (BMI), and individuals with a BMI value of ≥ 30 kg/m² are define...

WALANT technique versus general anesthesia in frozen shoulder manipulation: a prospective randomized controlled trial

Manipulation under anesthesia can rapidly improve pain and motion in refractory frozen shoulder but usually requires operating-room and anesthesiology resources. This trial compared an ultrasound-guided wide-awake local anesthesia no tourniquet (WALANT)-based outpatient protocol...

Retention behavior and surface alterations of ball and TRI raptor unsplinted overdenture attachments after thermomechanical aging: an in vitro study

Abstract Background To compare the time-dependent retentive-force behavior and wear-related surface alterations of two unsplinted overdenture attachment systems, a ball attachment system and a TRI Raptor Smart Box system, after standardized thermomechanical aging. Methods In this...

Maternal and neonatal outcomes following cesarean myomectomy: a comparison between fibroid-associated and fibroid-free cesarean deliveries

Objective: To compare maternal and neonatal outcomes among women undergoing cesarean section (CS) with concomitant myomectomy, women with uterine fibroids managed conservatively at cesarean delivery, and women without uterine fibroids. Material and Methods: This retrospective coh...

Turkish Cross-Cultural Adaptation of the BRIEF-MPI in Older Adults with Cancer: Convergent and Discriminative Validity Compared with the G8 and Clinical Frailty Scale

Background: Older adults with cancer represent a heterogeneous population with varying levels of frailty and multidimensional vulnerability. Rapid screening tools are needed to identify patients who may benefit from comprehensive geriatric assessment (CGA). This study aimed to tr...

Classification of Seasonal Allergic Rhinitis Patients by Prospective Patient‐Recorded Symptoms: The @ IT .2020 Project

BACKGROUND: Seasonal allergic rhinitis (SAR) has been so far classified according to frequency and severity by retrospective information based on the ARIA (Allergic Rhinitis and its Impact on Asthma) classification. Electronic symptom diaries (e-Diaries) are feasible tools to col...

A methodological framework for the standardised evaluation of olive genetic resources: GEN4OLIVE harmonized protocols

Background Olive ( Olea europaea L.) breeding initiatives rely heavily on the extensive and correct characterisation of genetic resources to successfully achieve their goals, such as addressing climate change and emerging diseases challenges. However, the historical lack of stand...

Investigation of anxiety and depression levels in nurses caring for organ transplant patients

Organ transplantation is a comprehensive care process that heavily utilizes technology and teamwork, directly impacting the quality of life of patients. In this process, nurses play a critical role not only in providing physical care but also in meeting the emotional and psycholo...

The psychosocial resilience experiences of healthcare workers following the 2023 Kahramanmaraş earthquakes: a qualitative study

This study explores the under-researched experiences of healthcare workers navigating a “dual-role” paradox, functioning simultaneously as traumatised disaster survivors and active responders during the 2023 Kahramanmaraş Earthquakes. Disasters fracture a community’s social fabri...

Visual and Semiquantitative Assessment of 123I-Ioflupane SPECT in Probable Dementia with Lewy Bodies and Its Association with Autonomic Dysfunction: A Retrospective Study

Background/Objectives: Dementia with Lewy bodies (DLB) is a clinically heterogeneous neurodegenerative disorder characterized by cognitive, neuropsychiatric, motor, and autonomic manifestations. Reduced striatal dopamine transporter availability on 123I-ioflupane single-photon em...

Innovative hybrid poppy oil‐alginate bigel material for neodymium recovery

Abstract The recovery of rare earth elements like neodymium (Nd(III)) has gained significant attention due to their critical industrial role and potential environmental impact when released into ecosystems. In this study, a novel biosorbent system combining poppy oil and alginate...

Renal outcomes following fundus fluorescein angiography in patients with diabetic nephropathy: Incidence, risk factors and three‐month kidney function changes

Abstract Aims The aim of this study was to determine the incidence of contrast‐associated acute kidney injury (CA‐AKI) after fundus fluorescein angiography (FFA) in a high‐risk diabetic nephropathy (DN) population, to identify clinical predictors of renal injury and to evaluate t...

Treatment Sequencing of CDK4/6 Inhibitors in Bone-Only Hormone Receptor-Positive Metastatic Breast Cancer: Multi-Center Real-World Data Revealing a Numerical Trend Favoring Later-Line Use

Background: Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy represent the gold standard in the first-line treatment of hormone receptor (HR)-positive, HER2-negative metastatic breast cancer (MBC). However, the optimal timing of CDK4/6i initiation...

Turkish adaptation of the Supportive and Palliative Care Indicators Tool (SPICT): a validity and reliability study

Abstract Background One of the major challenges in clinical practice in Türkiye is the lack of objective criteria for the early identification of patients requiring palliative care. The Supportive and Palliative Care Indicators Tool (SPICT™), developed by Murray SA and colleagues...