Izmir University

Reproductive cycle of invasive alien bivalve Brachidontes pharaonis (Fischer, 1870) in the Gulf of İzmir, Aegean Sea

Context The invasive Lessepsian bivalve Brachidontes pharaonis (P.Fischer, 1870) heavily aggregates on longline mussel farms in the Gulf of İzmir, causing spatial and nutritional competition on the commercially cultivated native mussel Mytilus galloprovincialis. Aims This study e...

Risk Factors for Lymphedema After Breast Cancer Surgery: A Prospective Cohort Study Evaluating Axillary Surgical Approaches

AIM: Breast cancer-related lymphedema remains a major complication that follows axillary surgery. This prospective study evaluated the effects of axillary surgical techniques and treatment-related factors on the development of lymphedema in patients undergoing breast cancer surge...

Mortality and kidney outcomes in ANCA-associated vasculitis: determinants from a real-world cohort

Abstract Introduction: ANCA-associated vasculitis (AAV) is a heterogeneous disease associated with substantial morbidity and mortality; however, data integrating both mortality and kidney outcomes within real-world cohorts remain limited. Objective: To evaluate mortality and kidn...

Association of Baseline Serum DKK-1 Levels with Subsequent Bone Metastasis in Stage III Breast Cancer

Background and Objectives: Bone metastasis is the most frequent site of distant spread in breast cancer, yet reliable biomarkers capable of identifying patients at increased risk before metastatic disease becomes clinically evident remain limited. We investigated whether baseline...

Cross-cultural adaptation and reliability, agreement, and construct validity of the Turkish neck disability 10 in patients with neck pain

PURPOSE: To cross-culturally adapt the Neck Disability 10 (ND10) into Turkish and evaluate its measurement properties in adults with neck pain and related disorders. MATERIALS AND METHODS: Following forward-backward translation, expert committee review, and cognitive debriefing,...

A Compact Unified Model for Moderate-to-Severe Carotid Artery Stenosis Using Image Segmentation: A Multicenter Study.

BACKGROUND: This study aimed to evaluate the diagnostic performance of a new artificial intelligence model, the compact unified model (CU-Model), for moderate-to-severe carotid artery stenosis using digital subtraction angiography (DSA) images compared to clinical reference stand...

Elranatamab in relapsed/refractory multiple myeloma patients on hemodialysis: A real-world case series

Background Renal impairment is a frequent and adverse prognostic factor in multiple myeloma (MM), with dialysis-dependent patients largely excluded from pivotal trials of B-cell maturation antigen (BCMA)-directed therapies. Elranatamab, a BCMA×CD3 bispecific antibody, has demonst...

Parameters predicting mortality in antifibrotic-treated IPF patients: mMRC, CPI, TLCO, FVC, GAP

BACKGROUND: Idiopathic pulmonary fibrosis(IPF) continues to be a fatal disease despite the use of antifibrotic therapy. There is limited data on the prognostic importance of parameters predicting mortality. We aimed to identify independent mortality predictors in antifibrotic-tre...

Divergent medulloblastoma chromatin states disclose KDM2B as a selective dependency

Abstract Medulloblastoma is a biologically heterogeneous childhood cerebellar tumor harboring frequent chromatin-modifying gene alterations. How these alterations promote transcriptional programs governing malignancy remains poorly defined. To address this knowledge gap, we evalu...

Is Early Fixation of Intra-Articular Calcaneal Fractures via the Sinus Tarsi Approach Safe?

Background: The aim of this study was to investigate the relationship between surgical timing and treatment outcomes in calcaneal fractures treated with the sinus tarsi approach. Methods: Eighty-eight patients with displaced intra-articular calcaneal fractures who were operated o...

Technique-stratified reintervention outcomes after surgical reconstruction for nutcracker syndrome: a single-center retrospective study

Nutcracker syndrome (NCS) is an uncommon venous compression disorder resulting from extrinsic compression of the left renal vein (LRV), either between the superior mesenteric artery (SMA) and the aorta (anterior NCS) or between the aorta and the vertebral body (posterior NCS). Ow...

Beyond optimisation: Revisiting energy demand management

Energy demand reduction (EDR) in households has re-emerged as a central pillar of climate and energy transition strategies in Europe and beyond. While energy efficiency has long dominated policy frameworks, growing evidence shows that efficiency alone is insufficient to achieve a...

Sub-THz Channel Characterization and Antenna Array Design for 6G Smart Factory Environments at 140 GHz

The ultra-high data rate and ultra-reliable low-latency communication (URLLC) requirements of Industry 4.0 and smart factory applications have made the evaluation of Sub-Terahertz (Sub-THz) frequencies, especially the 140 GHz band, in sixth-generation (6G) wireless networks a con...

Metal-reinforced PLA composites for material extrusion additive manufacturing: Interfaces and performance

Metal-reinforced polylactic acid (PLA) composites produced by fused deposition modeling/fused filament fabrication (FDM/FFF) offer thermal, electrical, magnetic, antimicrobial, biomedical, and post-processing functions. However, these benefits are often accompanied by reduced str...

Psychological resilience and suicidality in euthymic bipolar disorder: does metabolic syndrome matter?

Abstract Background Low psychological resilience has been linked to suicidality in bipolar disorder (BD), whereas the role of metabolic syndrome (metS) remains unclear. Resilience is multidimensional, yet it is not known whether its distinct components relate differently across t...

Orbitozygomatic-transsylvian approach to the insula: microsurgical anatomy and endoscopic correlation using the fiber-separation technique

Insular surgery remains technically demanding because of the region’s deep location and intimate relationships with the middle cerebral artery complex and surrounding white matter pathways. Safe resection requires precise understanding of vascular landmarks and subcortical functi...

Prognostic value of mNUTRIC and nutritional indices, including early change, for ICU mortality in older adults with AECOPD

Abstract Background Malnutrition is common in older adults with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) requiring intensive care unit (ICU) admission and is associated with adverse outcomes. We aimed to evaluate the prognostic value of the Prognostic...

Clearance of amino acids, trace elements, and carnitine during CRRT: the carnitine dichotomy

Continuous renal replacement therapy (CRRT) provides vital organ support in acute kidney injury but is associated with the inadvertent extracorporeal clearance of essential low-molecular-weight nutrients. While the loss of amino acids and trace elements is clinically recognized,...

Use of an ACL Tibial Drill Guide to Reduce Radiation Exposure During High Tibial Osteotomy: A Comparative Analysis

Background: Medial open-wedge high tibial osteotomy (HTO) is an established treatment for medial compartment osteoarthritis in patients with varus alignment. Accurate K-wire placement is essential for a safe and reproducible osteotomy, yet it often requires repeated fluoroscopic...

Genotype–cognitive phenotype associations in Duchenne muscular dystrophy: the role of mutation location and ambulatory status in a pediatric cohort

Duchenne muscular dystrophy (DMD) is characterized by progressive motor decline as well as cognitive impairment and reduced quality of life. This study aimed to investigate the relationship between genotype, cognitive functioning, and quality of life in children with DMD. This cr...