Icahn School of Medicine at Mount Sinai

Sociodemographic bias in LLMs’ clinical decision-making for dizziness

Objective As large language models (LLMs) enter clinical decision support, concerns persist about sociodemographic bias. We assessed whether LLM recommendations for dizziness vary by patient descriptors and clinical detail. Methods We conducted a cross-randomized in-silico vignet...

Peripheral Nerve Entrapment Mimics of Overuse Syndromes

Repetitive use injuries are commonly seen by musculoskeletal providers, usually in the form of tendinopathies. However, focal peripheral nerve entrapment can mimic or coexist with tendon pathology, particularly when weakness, sensory symptoms, or imaging findings are subtle or no...

A Vagal–Renal–Splenic Reflex Suppresses Renal Sympathetic Nerve Activity and Preserves Kidney Function After Ischemic Injury

Background: Acute kidney injury (AKI) is associated with maladaptive increases in renal sympathetic nerve activity (RSNA) and frequently progresses to chronic kidney disease. Neuromodulatory strategies that suppress sympathetic outflow may provide therapeutic benefit. We tested w...

Effect of Abrocitinib on the Skin Microbiome in Patients With Moderate‐to‐Severe Atopic Dermatitis

BACKGROUND: Atopic dermatitis (AD) is characterized by microbial dysbiosis, notably an overabundance of Staphylococcus species. This study aimed to evaluate the effects of abrocitinib, a Janus kinase 1-selective inhibitor, on the skin microbiome and clinical outcomes in patients...

Timing of Food Introduction and Allergy Prevention: An Update.

Recommendations about allergy prevention through diet are rapidly changing. In just the past several years, multiple organizations have provided updated guidance and recommendations about infant feeding based on recent studies and meta-analyses. In addition to the increased numbe...

Effects of early adulthood chronic sleep disruption on late life cognition, brain pathology, and microglial reactivity in the PS19 mouse model of tauopathy

Abstract A bidirectional relationship has been proposed between sleep and Alzheimer’s disease pathology, such that disruption to sleep can lead to increases in the expression of tau or its phosphorylation. Over the long term, this can potentially lead to greater expression of neu...

Context-sensitivity and longitudinal stability of the effects of depressive symptoms on social and reward decision-making

Depressive symptoms could affect decision-making in multiple ways, yet it remains unclear whether these effects are context-sensitive or stable over time. In this longitudinal study, 236 online participants (n=129 at 1-month follow-up) completed a social exchange task (Ultimatum...

Primary Cilia Regulate the Mechanical Adaptation of the Tendon and Enthesis via Hedgehog Signaling

Background: Physical loading mediates postnatal growth, homeostasis, and healing of the tendon and its attachment to bone, which is critical for rotator cuff functional integrity. Our prior studies have highlighted the mechano-sensing role of primary cilia; However, the mechanism...