Institution
Icahn School of Medicine at Mount Sinai
Recent research
- Health & MedicineOpen access
Traditional weight-based dosing results in variable rabbit anti-thymocyte globulin (rATG) clearance, delaying CD4+Tcell-immune-reconstitution (CD4 + IR) and impacting outcomes. In a retrospective pharmacokinetic/pharmacodynamic analysis of patients undergoing first T-replete hema...
- Health & MedicineOpen access
BACKGROUND: Despite continuous advancements in devices and techniques, transcatheter aortic valve implantation remains associated with complications impacting outcomes. In 2021, the Valve Academic Research Consortium (VARC) introduced the VARC-3 criteria to better classify proced...
- Climate & EnvironmentOpen access
Abstract Evidence linking ambient fine particulate matter (PM2.5) exposure to childhood neurodevelopmental disorders (NDDs) remains mixed. We conducted a cohort study (2001–2013) of 1,547,244 Medicaid-enrolled mother-child pairs to assess associations between zip-code–level PM2.5...
- Materials & EnergyOpen access
The simultaneous determination of non-metal elements in whole blood remains analytically challenging because of the complex biological matrix and the wide concentration range. This study describes a simple microwave-assisted alkaline extraction method for the determination of bor...
- Climate & EnvironmentOpen access
Wildland–urban interface (WUI) wildfires are increasingly important climate-related exposure events because they burn built infrastructure and can mobilize legacy contaminants in addition to generating smoke. Although the acute respiratory effects of wildfire smoke are well descr...
- Health & Medicine
ABSTRACT Background The VA Hospital in Home (HIH) model of care delivers acute‐level hospital care to Veterans at home across the country. We aim to examine the similarities and differences in the structure and implementation of existing HIH programs across sites to identify best...
- Climate & EnvironmentOpen access
Susceptible perinatal windows to arsenic exposure and serum antibody levels in children
Several cohorts have documented potential immunotoxic effects of arsenic in pediatric populations, however, the identification of susceptible windows to arsenic exposure remains poorly investigated in relation to vaccine-specific antibody responses. The present study examines per...
- BiologyOpen access
Abstract Advances in single-cell and -nucleus transcriptomics have enabled generation of increasingly large-scale datasets from hundreds of subjects and millions of cells. These studies promise to give unprecedented insight into the cell type specific biology of human disease. Ye...
- Society & EconomicsOpen access
A Scoping Review of Queer Health and Well-Being Technology Research
Technology has and will continue to have a significant impact on queer people’s health and well-being; however, it is not guaranteed that these implementations lead to meaningful advancements. Through a scoping review of 69 queer health technology papers in the ACM Digital Librar...
- BiologyOpen access
Single-nucleus transcriptome-wide association study of human brain disorders
Abstract Common brain disorders impose a substantial health burden, but localizing their genetic risk in the brain remains challenging 1 . Although genome-wide association studies have identified numerous loci associated with neuropsychiatric and neurodegenerative disorders, many...
- BiologyOpen access
Single-cell atlas of transcriptomic vulnerability across brain disorders
Abstract Neurodegenerative and neuropsychiatric diseases impose a considerable societal and public health burden. However, our understanding of the molecular mechanisms underlying these highly complex conditions remains limited 1,2 . Here, to gain deeper insights into the aetiolo...
- BiologyOpen access
Single-nucleus atlas of cell-type specific genetic regulation in the human brain
Abstract Genetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of th...
- BiologyOpen access
Personalized single-cell transcriptomics reveals molecular diversity in Alzheimer’s disease
Alzheimer’s disease (AD) is highly heterogeneous and driven by diverse molecular and cellular mechanisms. Functional genomics investigates these mechanisms from genetic variants to gene expression and regulation. We performed personalized functional genomics analysis on populatio...
- BiologyOpen access
Abstract Background Autistic individuals may experience elevated risk for post-traumatic stress disorder (PTSD). Although autism is more commonly diagnosed in males, females in the general population develop PTSD at approximately twice the rate, raising the question of whether au...
- Climate & Environment
BACKGROUND: Although enteric-coated aspirin is widely used instead of chewable formulations in patients with atherosclerotic cardiovascular diseases (ASCVD), its effects on cardiovascular and gastrointestinal outcomes remain uncertain. Separately, air pollution is a driver of car...
- BiologyOpen access
Lifespan single-cell transcriptomic atlas of the human prefrontal cortex
The human brain undergoes profound changes from early development through late adulthood, shaping cognition, behaviour and vulnerability to disease1,2. Understanding how these changes are organized within specific brain regions and cell types is essential for interpreting normal...
- BiologyOpen access
AI-based characterization of Alzheimer’s disease phenotypes from population-scale single-cell data
The complexity of Alzheimer’s disease (AD) manifests in diverse clinical phenotypes, including cognitive impairment and neuropsychiatric symptoms. However, the etiology of these phenotypes remains elusive. To address this, the PsychAD project generated a population-level single-n...
- Health & Medicine
Revisiting the role of lymphatics in Crohn's disease.
BACKGROUND: Early pathological observations consistently highlighted the involvement of the intestinal lymphatic system in Crohn's disease (CD), although this remains underappreciated in current conceptual models of disease pathogenesis. This narrative review synthesizes evidence...
- Health & MedicineOpen access
The DRESS/HLH Overlap Syndrome: A Systematic Review of Clinical Features, Triggers, and Outcomes
Background/Objectives: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome and hemophagocytic lymphohistiocytosis (HLH) are life-threatening conditions characterized by immune dysregulation. Several reports have identified an overlap between these entities; how...
- Health & Medicine
This study aimed to identify heterogeneous profiles of school teachers in rural China and to examine whether these profiles differed across sociodemographic, work-related, health behavior, and psychosocial factors. Participants were 513 teachers from rural schools in Hunan Provin...