Icahn School of Medicine at Mount Sinai

Erythropoietic protoporphyria life impact and genetic health trajectory (LIGHT) study in Europe: a cross-sectional online questionnaire

Abstract Background Erythropoietic protoporphyria and X-linked protoporphyria (collectively, EPP) are rare inherited metabolic disorders of the heme biosynthetic pathway characterized by severe photosensitivity and painful phototoxic reactions upon sunlight exposure. This study s...

Proteomic Immune Signatures of Severe HIV-Associated Tuberculosis in Sub-Saharan Africa: A Prospective, Multicenter Analysis From Uganda

Abstract Objective Severe tuberculosis (TB) is a major cause of critical illness and death in people living with HIV (PLWH) worldwide. Despite this, the immunopathology of severe HIV-associated TB (HIV/TB) is poorly understood. We aimed to identify an immunopathologic signature o...

Widening the therapeutic window: How tumor irradiation harnesses dendritic cells to locally amplify CAR T cells in solid tumor

Much effort has been devoted to making chimeric antigen receptor (CAR) T cell therapy as effective in solid tumors as it has become in B cell malignancies. Although clinical trials have demonstrated that doses up to 5 × 108 CAR T cells are generally safe, these doses rarely produ...

Daratumumab, lenalidomide, and dexamethasone in transplant-ineligible newly diagnosed multiple myeloma: MAIA final survival analysis

Abstract In previous analyses of MAIA, daratumumab plus lenalidomide/dexamethasone (D-Rd) significantly improved progression-free survival and overall survival (OS) versus lenalidomide/dexamethasone (Rd) in transplant-ineligible newly diagnosed multiple myeloma (NDMM). We report...

Care Team Response to Patient Portal Message Content and Writing Style

Importance Patient portal messages are an increasingly central channel for patient-clinician communication, but there are inequities in how responsive care teams are to messages sent by patients from historically marginalized groups. The reasons driving these disparities are not...

Analyzing the Effect of Nurse-Led Follow-Up Calls to Reduce Emergency Department Readmissions in Older Adults

PURPOSE: To evaluate whether nurse-led follow-up calls after emergency department (ED) discharge were associated with decreased 30-day ED revisits and hospital admissions among older adults in two geriatric practices. METHOD: The current retrospective quality improvement evaluati...

The needle-puncture mouse aortocaval AVF model: a state of the art review

Recent advances using the mouse needle-puncture aortocaval arteriovenous fistula (AVF) model have enhanced our understanding of the complex pathological changes occurring at the juxta-anastomotic area. Some of these changes include the presence of disturbed arteriovenous flow, fo...

Navigating physician-scientist careers: insights from American Board of Internal Medicine Research Pathway graduates

The American Board of Internal Medicine Research Pathway (ABIM RP) is designed to train physician-scientists by shortening postgraduate clinical training and increasing research time. We surveyed ABIM RP graduates to understand career trajectories, research engagement, and barrie...

Cutting chart-review time and improving database accuracy in inflammatory bowel disease with human-in-the-loop large language models

Abstract Background Manual abstraction of electronic health records into research databases is a major bottleneck in clinical research, limiting scalability and introducing error. This challenge is particularly acute in inflammatory bowel disease surveillance, where clinically re...

Pharmacokinetics of IL-23p19 Inhibitors: A Systematic Review Across Immune-Mediated Inflammatory Diseases

Interleukin (IL)-23p19 inhibitors are increasingly used in immune-mediated inflammatory diseases (IMIDs), particularly inflammatory bowel disease (IBD). Almost half of patients show inadequate response, partly due to pharmacokinetic (PK) variability. However, a comprehensive over...

Immunotherapeutic targeting of calreticulin mutant myeloproliferative neoplasms

Abstract Calreticulin (CALR) frameshift mutations drive the majority of JAK2 / MPL -wild-type cases of essential thrombocythemia and myelofibrosis, producing a shared novel C-terminus that activates the thrombopoietin receptor and leads to constitutive Janus kinase (JAK)/signal t...

Laser Interstitial Thermal Therapy for Brain Tumors: A Prospective Multicenter Analysis of Patients From the LAANTERN Study

Background: Laser interstitial thermal therapy is a surgical tool used to ablate brain tumors, radiation necrosis, and epileptic foci. Data from the completed LAANTERN prospective multicenter registry (NCT02392078), containing tumor patients enrolled in the study across 25 US cen...

Virtual coronary artery bypass grafting

<title>Abstract</title> Coronary artery bypass grafting (CABG) offers superior long-term survival over percutaneous coronary intervention (PCI) or medical therapy in patients with complex coronary artery disease (CAD). This prospective proof-of-concept study aims to develop and v...

Moving From Laboratory to Clinical Metrics for Diagnostic Tests

This Viewpoint explores the distinction between analytical and diagnostic performance measures.

Study protocol for first national vasa previa perinatal registry

Vasa previa is a rare but potentially catastrophic obstetric condition characterized by unprotected fetal blood vessels over or adjacent to the internal cervical os. Although advances in prenatal ultrasound have dramatically improved neonatal survival through planned cesarean del...

Acute effects of the 1-minute sit-to-stand test (STST) on immune-metabolic stress indices

Abstract Characterizing the non-pathological, exercise-induced immune-metabolic stress regulation is important for understanding physiological adaptations and distinguishing them from maladaptive responses. Because such responses are mostly studied with extensive, resource-intens...

Community-Led Operationalization of a Champion Implementation Strategy for Anal Cancer Prevention in Nigeria

Abstract Context-specific adaptation of implementation strategies is an important component of promoting evidence-based intervention use. But guidance on systematic approaches is limited. Here we described our mixed method approach to adapting (Study 1) and monitoring (Study 2) a...

Nuclear activities and interactome of the NS5 protein of tick-borne encephalitis virus

Orthoflaviviruses are RNA viruses responsible for significant diseases in humans, domesticated animals, and wildlife. Their NS5 protein is central in viral replication, functioning both as an RNA-dependent RNA polymerase and a methyltransferase, while also modulating cellular pro...

Technical note: reconstructing dose distributions from manually planned electron boosts in breast radiotherapy

Purpose In breast radiotherapy, delivery of manually-calculated electron boosts limits retrospective dose–response analyses as dose distribution is unavailable. This work evaluates the feasibility of reconstructing dose distributions from manually planned electron boosts in breas...

Targeting Oncogenic KRAS Using Peptide Nucleic Acid Oligomers Attached to Cell-Penetrating Peptides

Approximately 30% of tumors contain an activating mutation in the oncogene KRAS, leading to increased cell proliferation that often promotes non-small cell lung cancers, colorectal adenocarcinomas, pancreatic ductal adenocarcinomas (PDAC), and other cancers. Among the most common...