Icahn School of Medicine at Mount Sinai

Low-pressure pneumoperitoneum in robot-assisted radical prostatectomy: a systematic review, meta-analysis and trial sequential analysis of randomized controlled trials

Abstract Purpose Low-pressure (LP) pneumoperitoneum (intra-abdominal pressure [IAP] <12 mmHg) has been proposed to reduce pain after robot-assisted radical prostatectomy (RARP), but earlier syntheses combined randomized with non-randomized data, pooled mixed urological procedures...

Prenatal exposure to wildfire fine particulate matter and fetal growth outcomes in the United States: Findings from the ECHO Cohort

Background: Increasing exposure to wildfire fine particulate matter (PM 2.5 ) may pose unique risks to fetal development. We assessed associations between prenatal wildfire PM 2.5 exposure and fetal growth outcomes, including birth weight at term, birth weight for gestational age...

Review of Hypoxemia Quantification Methods for Assessing the Severity of Obstructive Sleep Apnea

Abstract Purpose of Review Obstructive sleep apnea (OSA) is a common nocturnal breathing disorder characterized by recurrent upper airway obstruction during sleep, leading to sleep fragmentation and intermittent hypoxemia. The apnea-hypopnea index (AHI) is the most widely used cl...

Rapid progression of coronary atherosclerosis across glycemic status: a serial coronary computed tomography angiography study from the PARADIGM registry

Rapid progression of coronary atherosclerosis is associated with an increased risk of future adverse cardiovascular events. However, evidence regarding the association between glycemic status and rapid plaque progression (RPP) in the major epicardial coronary arteries remains lim...

Functional connectivity of the locus coeruleus in anxiety and posttraumatic stress disorder reveals convergent mapping to the cingulate cortex and insula using ultra-high field 7 Tesla MRI

Abstract Cortical and subcortical correlates of anxiety and stress disorders have been well defined over recent decades. However, the role of the locus coeruleus (LC), which is responsible for synthesizing and releasing a majority of the brains’ norepinephrine, has been less wide...

Beyond Event Frequency: Respiratory Effort Reveals Mortality Risk in Obstructive Sleep Apnea

Nasim Montazeri, Ankit Parekh; Beyond Event Frequency: Respiratory Effort Reveals Mortality Risk in Obstructive Sleep Apnea, American Journal of Respirator

Intra-tumoral epigenetic heterogeneity and aberrant molecular clocks in hepatocellular carcinoma

There is limited understanding of the epigenetic drivers of tumor evolution in hepatocellular carcinoma (HCC). Here we characterize the epigenetic contribution of methylation to intra-tumoral heterogeneity (mITH) using regional enhanced reduced-representation bisulfite sequencing...

Berberine Inhibits Eczematous Skin S. aureus-Induced Mast Cell/Basophil Activation and Modulates MAPK-Associated Gene Expression

Staphylococcus aureus (S. aureus), a primary exacerbating factor in eczema, remains a prevalent pathogenic public-health threat. The mechanism of mast cell/basophil degranulation in the context of S. aureus-exacerbated eczema remains unclear. We sought to investigate the direct e...

Physics-Informed and Data-Driven Forecasting of Chaotic Dynamics Across Lorenz and Rössler Systems

Reliable finite-horizon forecasting of chaotic dynamics is challenging because small approximation errors grow rapidly during recursive prediction. This study presents a controlled comparison of data-driven and physics-regularized forecasting methods for the Lorenz and Rössler sy...

Safety and Performance of the Colovac Anastomosis Protection Device. A Pooled Analysis of Prospective Studies Compared With Diverting Loop Ileostomy (SAFE-2025)

Objective: To compare the safety and effectiveness of the Colovac Anastomosis Protection Device with standard diverting ostomy (DO) following low anterior resection (LAR) for rectal cancer. Summary Background Data: DO is standard of care (SOC) following LAR for rectal cancer but...

Identifying Contextual Factors affecting Hospital In Home Program Implementation within the Veterans Health Administration

Abstract Background and Objectives Understanding the factors that enable or hinder successful implementation is essential for improving patient outcomes. Hospital in Home (HiH) programs provide hospital-level care in patients' homes to reduce hospitalization, enhance satisfaction...

A Finite Element Model of Pregnancy Derived From Maternal Sonography: Effect of Uterine And Cervical Structural Properties on Cervical Mechanical Loading

Identification and treatment of pregnancies at risk for preterm birth is a central challenge in obstetric research. Many of the known causes of preterm birth originate from mechanical failure in reproductive tissues. To better understand the biomechanical environment of the gravi...

Cullin 3 ubiquitin ligase regulates redox defense and metabolic programs in proximal tubule cells

Abstract Background Chronic kidney disease (CKD) is characterized by proximal tubule (PT) stress, oxidative injury, and metabolic dysfunction. Human kidney single-nucleus RNA-sequencing (snRNA-seq) identified enrichment of ubiquitin-dependent protein catabolic processes in injure...

Antithrombotic therapy after percutaneous coronary intervention in patients with atrial fibrillation: an individual patient data network meta-analysis

BACKGROUND AND AIMS: Randomized trials demonstrated that in patients with atrial fibrillation (AF) undergoing percutaneous coronary intervention (PCI) direct oral anticoagulants (DOAC) and a P2Y12 inhibitor reduce bleeding compared with vitamin K antagonist (VKA) plus dual antipl...

Talquetamab for people living with relapsed/ refractory multiple myeloma: plain language summary of the MonumenTAL-1 study

Plain Language SummaryWhat is this summary about?This summary describes how well talquetamab worked and its safety at a median (midpoint) of 17–26 months follow-up from the MonumenTAL-1 study, which tested talquetamab treatment for a type of cancer called relapsed/refractory mult...

One vs twelve month aspirin after percutaneous coronary intervention for acute myocardial infarction: individual patient-data analysis of TARGET-FIRST and ULTIMATE-DAPT trials

Giuseppe Tarantini, Xiaojuan Zhang, Luca Nai Fovino, Jing Kan, Zhen Ge, Guillaume Cayla, Pieter C Smits, Benjamin Honton, Valeria Paradies, Yann Poezevara,

Prognostic performance of composite PE shock score in comparison and combination with PESI and ESC risk classification: a retrospective cohort study

PESI and ESC risk classification are widely used for early risk stratification of acute pulmonary embolism (PE). The Composite PE Shock (CPES) score has been proposed to better identify normotensive shock. We compared the prognostic performance of PESI, ESC risk class, and CPES....

CpG 1018 and alum synergistically enhance systemic and mucosal immunity to an N2 neuraminidase vaccine

Recombinant neuraminidase (rNA) is a promising target for broadly protective influenza vaccine development but typically requires adjuvants, especially for intranasal (IN) delivery. We evaluated an N2 rNA vaccine construct (globular head domain of NA, stabilized with a measles vi...

Animal-Assisted Therapy in Dementia: A Systematic Review and Meta-Analysis of Cognitive, Affective, and Behavioral Outcomes

Background/Objectives: Behavioral and psychological symptoms of dementia (BPSD) are common and represent major drivers of caregiver burden and healthcare utilization. Animal-assisted therapy (AAT) is used as a non-pharmacological intervention in dementia care, yet quantitative ev...

Ligand-Induced Stability Studies at the TSH Receptor Show the Linking Region to be a Chameleon

Glycoprotein hormone receptors (GPHRs) share a conserved architecture but the thyroid-stimulating hormone receptor (TSHR) is unique in possessing a large 141-amino-acid region called the hinge or linking region (LR) that contains a 50-amino-acid post translational cleavage site....