Icahn School of Medicine at Mount Sinai

Artificial Intelligence for Cardiac Ischemia Detection: A Review of Biosensor, Biomarker, and Imaging Applications

Ischemic heart disease is the leading cause of global mortality, yet accurate and timely detection remains constrained by incomplete signal capture, noise, operator dependence, and imperfect reference standards. Artificial intelligence (AI) may enhance cardiovascular sensing by e...

Long-Term Protection from Severe Hypoglycemia Following Pancreas Transplantation: A Single-Center Cohort Study

Background: Patients with type 1 diabetes complicated by severe hypoglycemia and impaired awareness remain at high risk of mortality despite advances in diabetes treatment. Pancreas transplantation offers definitive β-cell replacement; however, contemporary real-world data on hyp...

Short-Term Outcomes After Corticosteroid Injection in Patients with Clinically Diagnosed Subacromial Pain Suggestive of Bursitis

Background: The current diagnostic paradigm for clinically suspected subacromial bursitis is based on clinical history and physical examination. However, clinical signs frequently overlap with other pathologies. This study investigated short-term outcomes following the currently...

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

The association between COVID-19 pandemic-related birth plan changes and birth trauma symptoms in a New York City cohort

Abstract Background COVID-19-related changes to maternity care have frequently resulted in deviations from planned birth experiences. Discrepancies between expected and actual birth experiences are a risk factor for birth trauma. This study examined the associations between pande...

IncobotulinumtoxinA for Upper Limb Essential Tremor: A Randomized, Double-Blind, Placebo-Controlled Trial

This double-blind, placebo-controlled, phase II trial (NCT04766723) investigated the efficacy and safety of incobotulinumtoxinA (Xeomin®) in the treatment of essential tremor (ET) of the upper limb (UL). Adults with ET of the UL were randomized 2:1 (n = 78) and treated (n = 77) w...

Dietary nutrients and biotics protect against injury to intestinal epithelial barrier in alcohol use disorder: A narrative review

The intestinal epithelial barrier is anatomically and functionally distinct and specifically refers to the barrier formed by epithelial cells (enterocytes) and associated junctional complexes (tight junctions, adherens junctions, and desmosomes). The junctional complex is compose...

The circulating lipidome in severe obesity

Severe obesity (SevO; BMI ≥ 40 kg/m 2 ) is rising globally yet remains understudied mechanistically. To characterize lipidomic alterations at the species level, we analyzed Border Health Research Cohort participants with fasting plasma lipidomics and genetic data, comparing SevO...

Reducing Intervention and Length of Stay for Neonates With Transient Tachypnea of the Newborn

BACKGROUND AND OBJECTIVE: Transient tachypnea of the newborn (TTN) is a common respiratory disorder affecting late-preterm and term infants. Newborns with TTN are typically admitted to the neonatal intensive care unit (NICU) for medical care. Our objective was to reduce NICU leng...

Targeted Analysis of >1500 Plasma Proteoforms via Individual Ion Mass Spectrometry

Abstract Plasma proteomics has emerged as a powerful approach for interrogating human biology, identifying disease-associated proteomic changes, and advancing precision diagnostics. In recent years, affinity-based plasma proteomics platforms with predefined protein panels, such a...

Clarifying the Concept of “Unanticipated Transfer to the ICU”: A Scoping Review

Unanticipated transfer to the intensive care unit (ICU), typically defined as an unscheduled escalation of care from inpatient general wards, is widely used in clinical research as a marker of adverse events, clinical deterioration, and system failure. However, its conceptual mea...

Telecardiology bridges the gap in pediatric heart care: A systematic review

Background Geographic disparities limit access to pediatric cardiology care in rural and underserved communities, contributing to delayed diagnosis, increased transfers, higher costs, and preventable morbidity. Telecardiology has emerged as a scalable strategy to address subspeci...

Sweet syndrome and thyroid diseases: a case-based review of a possible association

Sweet syndrome, also known as acute febrile neutrophilic dermatosis, is a rare dermatological condition characterized by the abrupt onset of tender, erythematous skin lesions, often presenting with fever and systemic inflammation. It is commonly associated with infection, maligna...

Lipid Burden and Efficacy of Preventive PCI of Vulnerable Atherosclerotic Coronary Plaques: Post Hoc Analysis From the PREVENT Trial

BACKGROUND: Preventive percutaneous coronary intervention (PCI) of non–flow-limiting lesions (fractional flow reserve >0.80) that are high-risk plaques has emerged as a potential strategy to reduce cardiac events. However, identifying which lesions derive the greatest benefit fro...

Neuropsychiatry genetics in Africa

Across Africa, rising mental health needs coincide with rapid advances in genomics, digital health and continental policy reform. Yet research into the genetic, environmental and social determinants of neuropsychiatric illness remains sparse and underfunded. This review argues th...

Establishing Stakeholder Priorities for Development of a Multi‐Arm Multi‐Stage Platform Trial in Crohn's Disease

ABSTRACT Background and Aims The expanding range of advanced therapies for Crohn's disease (CD) has increased complexity in treatment selection, particularly in refractory disease. Conventional randomised controlled trials are limited in evaluating multiple treatment strategies e...

Brain signatures of body mass index predict cardiometabolic and respiratory disease status

Abstract Despite advances in brain biomarkers using neural networks, the effects of body mass on brain structure have been neglected, particularly in connection with noncommunicable diseases. Here, we isolated brain biomarkers of body mass index (BMI) and evaluated their associat...

A Multi-Stage Deep Learning Framework for Daily PM2.5 Estimation at 100 m Resolution Across the Contiguous United States, 2000–2024 (A Quarter Century of Data)

Abstract Accurate high-resolution estimation of fine particulate matter (PM2.5) remains challenging because of sparse monitoring networks and missing satellite observations. We developed a multistage deep learning framework to generate daily PM2.5 concentrations at 100 m resoluti...

Loss of the tumor suppressor p53 generates a signaling gradient that drives epithelial clonal expansion

Although tumor protein p53 ( TP53 ) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we found that p53 suppresses clonal expansion by limiting progenitor self-renewa...

Connectomic Determinants of Subcallosal Cingulate Deep Brain Stimulation for Depression

OBJECTIVE: Subcallosal cingulate (SCC) deep brain stimulation (DBS) has shown promise for treatment-resistant depression. This study retrospectively evaluated a large curated SCC-DBS dataset to identify connectomic factors associated with sustained clinical improvement across pat...