Huazhong University of Science and Technology

Is the accretion flow magnetically arrested in M87?

Abstract It is still debating on whether the disc is magnetically arrested in M87. We assume that a weak external magnetic field is dragged inwards by the accretion disc, which is substantially enhanced to drive strong jets near the black hole horizon via Blandford-Znajek mechani...

Associations of PM2.5 Components, Residential Greenness, and Heatwaves with Incident Venous Thromboembolism

Abstract Aims This study aimed to explore the associations of fine particulate matter (PM2.5) components, residential greenness, and heatwaves with incident venous thromboembolism (VTE). Methods This study included 483,610 participants from the UK Biobank (mean age 56.5 years; 54...

SGLT2 inhibitor ameliorates hypertension by regulating the CYP4A/20-HETE pathway in the kidney

Sodium-Glucose Transport Protein 2 inhibitors (SGLT2i), initially developed as antidiabetic agents and now established as foundational therapies for heart failure, have also shown antihypertensive effects in clinical trials involving patients with diabetes and heart failure. Howe...

A Poly(lactic Acid)‐Porphyrin‐Cobalt Vaccine Adjuvant System Elicits Protein‐ or Peptide‐Specific Humoral and Cellular Immunity

ABSTRACT There is growing interest in vaccine adjuvant systems that are scalable, adaptable, and capable of stimulating humoral and cellular immune responses with recombinant protein or synthetic peptide immunogens. In this study, we introduced a “plug‐and‐play” nanoadjuvant syst...

Nanomaterial engineering for recoil management and daughter-nuclide redistribution in targeted alpha therapy

Recent advances in targeted alpha therapy have highlighted a central but still unresolved nanobiotechnology problem, namely how to control the fate of recoil daughters after alpha decay. After alpha decay, recoil daughters may escape from the carrier and redistribute to non-targe...

POU4F3 variants are prevalent in Chinese patients with autosomal dominant non-syndromic hearing loss and concurrent tinnitus

POU4F3 (DFNA15) is an established causative gene for autosomal dominant non-syndromic hearing loss (ADNSHL); however, its mutational spectrum in the Chinese population remains incompletely characterized. This study aimed to expand the mutational spectrum of POU4F3 in the Chinese...

Simultaneous broad-spectrum antibacterial and regenerative therapy for diabetic wounds using sonosensitive peptide composite hydrogel

Diabetic wound infections remain highly refractory to treatment due to persistent bacterial colonization, oxidative stress, dysregulated inflammation, vascular insufficiency, and impaired extracellular-matrix remodeling. Current therapeutic strategies remain limited by poor tissu...

Learning in Lost-Sales Inventory Systems with Stochastic Lead Times and Random Supplies

Supply uncertainty, characterized by stochastic lead times and random supply quantities, has attracted increasing attention from academia, industries, and governments, particularly in the aftermath of the COVID-19 pandemic. In this paper, we consider the problem of managing lost-...

Stem Cell-Derived Extracellular Vesicles for the Treatment of Osteoporosis: A Systematic Review of Preclinical Evidence

Background: Osteoporosis is a prevalent skeletal disorder characterized by reduced bone mass and microarchitectural deterioration, resulting in an increased risk of fractures. Stem cell-derived extracellular vesicles (EVs) have emerged as a promising cell-free therapeutic strateg...

Assessing China’s COVID-19 control measures: a quantitative analysis based on a SIRD model

Abstract This paper established a Susceptible-Infected-Recovered-Dead (SIRD) model to fit and predict the COVID-19 epidemic in China. On the premise of passing the Markov Chain Monte Carlo (MCMC) robustness check, we counterfactually assessed the effectiveness of partial unlockin...

Spatial-seasonal distribution and ecological risk assessment of multiple herbicides (chloroacetamides, triazines, chlorophenoxy acids, bentazone) and their transformation products in the Yangtze River, China

Abstract Herbicides such as chloroacetamides, chlorophenoxy acids, triazines, and bentazone are widely used in agriculture, contaminating aquatic ecosystems. However, their distribution and ecological risks in the Yangtze River are not clear. Thus, we analyzed 144 surface water s...

Discharge Characteristics and Bactericidal Effects of a Self-Condensing Water-Electrode Plasma

This study proposes a self-condensing water-electrode plasma device in which ambient water vapor is condensed on a cooled needle-tip electrode within a strong electric-field region, forming continuously renewed water droplets, Taylor cones, or water-film interfaces that participa...

DSLHash: Lightweight Hash Function Based on SVSC 4D Chaotic System and Dynamic Substitution Layers

Data integrity remains a critical requirement for secure communication in IoT environments. To address this challenge for resource-constrained IoT devices, lightweight cryptographic hash functions have been widely studied. However, static substitution layers in conventional hash...

Lunar surface energy infrastructure: from in-situ resource utilization to deep space exploration

Sustainable, high-power energy infrastructure is essential for lunar bases yet must withstand the Moon’s extreme environment. This review compares power-generation, storage, and grid technologies across performance, environmental adaptation, in-situ resource utilization (ISRU) co...

Roles of spinal V3 interneurons: Roles in controlling movement in healthy and injured conditions.

Spinal V3 interneurons are glutamatergic neurons that are distributed among the dorsal, intermediate, and ventral spinal cord. They are involved in broad neural circuit connections in the central nervous system. Functionally, they play important roles in locomotion, such as the m...

Effects of continuity of care on avoidable hospitalization in hypertensive patients: a retrospective analysis in high-altitudes of China

In recent years, the hospitalization rate in China has continued to rise, with an increasing prevalence of avoidable hospitalizations. While developed countries have extensively studied avoidable hospitalization, research in China remains limited, particularly regarding the effec...

Multi-Scale CFD Investigation of Viscous Scale Effects on Bulbous Bow Slamming Pressures and Full-Scale Extrapolation

Predicting wave slamming pressures on bulbous bows is essential for ship structural safety. This study employs an overset-grid RANS-VOF framework to investigate viscous scale effects on bulbous bow slamming loads. Multi-scale simulations were conducted across four geometric scale...

Extracellular matrix remodeling upregulates hippocampal neurogenic niche stiffness and impairs neurogenesis in Alzheimer's disease

Abstract INTRODUCTION Preserving adult hippocampal neurogenesis alleviates cognitive deficits in Alzheimer's disease (AD), yet how biophysical alterations in such as stiffness in the neurogenic niche regulate neurogenesis remains unclear. METHODS Stiffness in the hippocampal dent...

A Novel Sparse Cellular Labeling System with Tunable Gradients and Long‐Term Stability

ABSTRACT The dense packing of cells within tissues poses challenges for studying cellular properties. Sparse labeling, genetically targeting a small subset of densely distributed cells, provides a powerful approach to investigate cellular morphology, connectivity, dynamics, and f...

Association of the Chinese visceral adiposity index with incident cardiovascular disease in cardiovascular-kidney-metabolic syndrome stages 0–3: a nationwide prospective cohort study

Abstract Background Cardiovascular-kidney-metabolic (CKM) syndrome integrates metabolic abnormalities, chronic kidney disease, and cardiovascular disease (CVD), with stages 0–3 representing a critical window for primary prevention. Whether the Chinese visceral adiposity index (CV...