Huazhong University of Science and Technology

Crosstalk Between CTSB + Glioblastoma Cells and S100A10 + Macrophages: A Self‐Reinforcing Circuit Promotes Immune Evasion and Limits Response to Immunotherapy

ABSTRACT Background : Glioblastoma (GBM) establishes a highly immunosuppressive microenvironment through intricate molecular dialogues with tumor‐associated macrophages (TAMs), contributing to immunotherapy resistance. Methods : We integrated advanced biological network analyses...

Lattice Dynamics Coupled at an Interface

A coupled lattice dynamical system generated by two infinite lattice differential equations meeting asymptotically at an interface is studied. This can be interpreted as a special case of dynamics on graphs with the sum of inputs and outputs at each node satisfying the Kirchhoff...

Effects of a work stress coping program based on social support theory for nurses returning to work after childbirth: a quasi-experimental study

Abstract Background Social support theory has been useful in stress management. The number of nurses returning to work after childbirth is increasing. However, return to work is often accompanied by substantial stress and return discomfort. Therefore, it is necessary to develop a...

Corilagin attenuates osteoarthritis progression by coordinating NF-κB inhibition with PI3K/AKT/mTOR-associated autophagy restoration

Background Osteoarthritis (OA) is characterized by persistent inflammation, extracellular matrix (ECM) degradation, and impaired autophagy. Corilagin is a natural ellagitannin with anti-inflammatory properties, but its effects on OA remain unclear. Methods IL-1β-stimulated primar...

SPR‐UPLC‐QTOF/MS‐GNPS‐Guided Discovery of Hypermonol J as a Novel Tumor Necrosis Factor‐Binding Small‐Molecule Lead for Inflammatory Storm Intervention

ABSTRACT This study developed an integrated strategy combining surface plasmon resonance (SPR) for real‐time biomolecular interaction analysis, ultra‐performance liquid chromatography coupled with quadrupole time‐of‐flight mass spectrometry (UPLC‐QTOF/MS) for compound profiling,...

Long‐term efficacy of adjunctive cenobamate: Open‐label extension of a randomized, placebo‐controlled study in a multinational Asian population

OBJECTIVE: This study was undertaken to assess long-term efficacy, safety, and tolerability of adjunctive cenobamate in an open-label extension (OLE) of a randomized, double-blind, placebo-controlled, dose-response study (NCT04557085; YKP3089C035 [Study C035]) in Asian patients w...

Association between the ratio of serum uric acid to high-density lipoprotein cholesterol in early pregnancy and the incidence of gestational diabetes mellitus: a prospective cohort study

To investigate the ratio of uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) (UHR) in early pregnancy and the risk of gestational diabetes mellitus (GDM), and to evaluate its potential predictive value as a risk indicator for early identification of GDM among pregna...

Asian Neurogastroenterology and Motility Association and Asia-Pacific Association of Gastroenterology Chronic Constipation Consensus 2026.

Background/Aims: : Chronic constipation is a common gastrointestinal (GI) disorder in Asia, characterized by heterogeneous symptom presentation, frequent overlap with other GI symptoms, and limited access to specialized diagnostic tests in many settings. These factors contribute...

Autonomous Vehicles, Urban Deployment, and Welfare Effects

ABSTRACT This paper provides a theoretical analysis of the effects of autonomous vehicles (AVs) on the spatial structures of future cities. We consider two types of AVs, private AVs (PAVs) and shared AVs (SAVs). We assume that AVs have a lower marginal travel time cost than human...

Waltz: Temperature-Aware Cooperative Compression for High-Performance Compression-Based CSDs

Data compression is widely adopted for modern solid-state drives (SSDs) to mitigate SSD lifetime issues. Researchers have proposed compression schemes at different system layers, including device-side solutions like CCSDs ( c ompression-based c omputational S SD s) and compressio...

Sirtuin 1 Inhibition Attenuates Viral Myocarditis by Suppressing the Nuclear Translocation of Pyruvate Kinase M2 to Rebalance Th17/Th9 Differentiation

Sirtuin 1 (SIRT1) regulates CD4 + T cell differentiation, particularly Th17 and Th9 subsets, in various autoimmune and inflammatory diseases, but its role in viral myocarditis (VMC) remains poorly understood. In this study, using a coxsackievirus B3 (CVB3)-induced VMC mouse model...

The double-edged sword of co-creation in the ride-hailing economy

Purpose This paper applies service-dominant logic (SDL) to labor–capital relationships to explore how service drivers' perceived value is shaped in the presence of customer participation, under working conditions such as control and conflict in algorithm management. It analyzes t...

Collaborative Inference and Learning between Edge SLMs and Cloud LLMs: A Survey of Algorithms, Execution, and Open Challenges

As large language models (LLMs) evolve, deploying them solely in the cloud or compressing them for edge devices is increasingly inadequate due to latency, privacy, cost, and personalization concerns. This survey examines a collaborative paradigm in which cloud-based LLMs and edge...

Precision Dosing for Pediatric Growth Hormone Deficiency With Daily and Weekly Growth Hormone

ABSTRACT Pediatric growth hormone deficiency (GHD) typically requires daily injections of recombinant human growth hormone (rhGH). Long‐acting PEGylated recombinant human growth hormone (PEG‐rhGH) formulations have been developed to reduce injection frequency and improve adherenc...

Make Lemonade out of Lemons: A Learning-based ZNS SSDs with Built-in Compression

Zoned Namespace (ZNS) SSDs offer a promising approach to simplifying flash management and reducing storage costs. Enabling built-in compression in ZNS SSDs can further enhance storage efficiency and improve performance without increasing the host’s burden. However, compression in...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Targeting NOX1/4 promotes macrophage phagocytosis and improves radiotherapy via YAP1/TEAD4-CD47 in non-small cell lung cancer

Abstract Radiotherapy is a mainstay treatment option for non-small cell lung cancer (NSCLC). However, radiation remodels the tumor immune microenvironment by adaptively upregulating the immunoregulatory checkpoint CD47, leading to phagocytic evasion and radioresistance. Although...

High‐Entropy Perovskites for Oxygen Evolution Reaction: Progress, Challenges, and Prospects

ABSTRACT Electrochemical energy storage and conversion systems powered by renewables underpin the clean energy transition, yet sluggish oxygen evolution reaction (OER) severely limits energy efficiency, driving demand for efficient OER catalysts. Perovskites stand out for adjusta...

Arc-DED additive manufacturing of high-Zn-content Al-Zn-Mg-Cu alloy assisted by interlayer remelting and mechanical hammering

Arc-directed energy deposition (Arc-DED) is a promising additive manufacturing technology for fabricating medium-to-large-scale and lightweight structural components. The development of high-strength aluminum alloys is crucial for optimising the performance of these Arc-DED-manuf...

Statistical Evidence for Factors Associated With Positive Leader Branching in Long Air‐Gap Discharges

Abstract Branching is a common feature in positive leader development, which changes the channel topology and significantly influences discharge behavior. However, the factors associated with its occurrence remain poorly understood. In this study, an event‐based analytical framew...