Harbin Medical University

Prognostic Associations of BMI and Metabolic Syndrome With Outcomes After Anti‐ PD ‐1 Therapy in Recurrent or Metastatic Nasopharyngeal Carcinoma

ABSTRACT To evaluate the associations of body mass index (BMI) and metabolic syndrome (MetS) with outcomes in patients with recurrent or metastatic nasopharyngeal carcinoma (R/M‐NPC) receiving anti‐PD‐1 therapy, and to develop a prognostic model for overall survival (OS). This mu...

Tripartite motif protein 32 overexpression promotes inflammation and pyroptosis in INS-1 cells via the NF-κB/NLRP3 signaling pathway under high glucose conditions

Abstract Background: Type 2 diabetes mellitus (T2DM) is an inflammatory disease, and the primary features are insulin resistance and β-cell dysfunction. Inflammation and pyroptosis contribute to insulin resistance and β-cell dysfunction. Therefore, it is important to identify nov...

Integrated Single Cell Analysis Reveals the Transcriptional Heterogeneity of Mouse Double Negative T Cells

Double negative T cells (DNT cells) are a rare T cell population involved in immune regulation, inflammation, autoimmunity, transplantation, and tumor immunity. However, their low abundance and dispersed distribution across tissues have limited a systematic understanding of their...

Efficacy and Safety of the First Adalimumab Biosimilar in Chinese Children with Severe Plaque Psoriasis: The PISCES Study, a Multicenter Prospective Study

Adalimumab, a monoclonal antibody targeting tumor necrosis factor-alpha, has been approved for the treatment of severe plaque psoriasis in children aged 4 years and older. Data on its use in the clinical management of pediatric psoriasis in China remains limited. This study is th...

Decreased mechanosensitivity and metabolic reprogramming impair bone regeneration in type II diabetes: core mechanism and targeted scaffold design

Abstract Background Bone regeneration in individuals with type 2 diabetes mellitus (T2DM) is significantly impaired, even when autologous bone grafts are used. However, previous studies have failed to elucidate the physiological mechanism, and effective treatments are lacking. Th...

Anti-cancer drug clinical research

Abstract Malignant tumors are major diseases that seriously threaten human health, and the unmet clinical demand for treatments in the field of oncology has been persistently large. The research and development of new antineoplastic drugs has become a powerful means to address th...

Efficacy and Safety of Recibokibart, an Interleukin-36 Receptor Antibody, in Generalized Pustular Psoriasis: A Phase 2 Randomized Trial

BACKGROUND: Generalized pustular psoriasis (GPP) is a rare, severe inflammatory skin disease characterized by acute flares. Recibokibart is a humanized IgG1 monoclonal antibody targeting the interleukin-36 (IL-36) receptor. In a phase 1b open-label study, a single intravenous dos...

Crystalline topographical construction: endogenous grooves as physical cues for stem cell regulation in bone regeneration

Micro/nano-topographical cues are potent regulators of cellular behavior and function. However, conventional fabrication techniques (e.g., photolithography, nanoimprinting) rely on complex exogenous processing that often induces surface energy loss and impairs biological signal t...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

RNA-Binding Protein MBNL2 Drives Cardiac Hypertrophy and Dysfunction by Facilitating TPM3 Splicing

BACKGROUND: Cardiac hypertrophy is a major contributor to heart failure development, making its prevention and treatment critical for reducing heart failure–associated mortality. Although alternative splicing is recognized as a key regulatory mechanism in myocardial hypertrophy,...

Oxalate induces phosphatidylserine externalization, apoptosis, and crystal-cell adhesion in renal tubular epithelial cells through the ROS-ADAM17-Notch1 axis

Abstract Background Oxalate salts induce reactive oxygen species (ROS) generation, leading to phosphatidylserine (PS) externalization from renal tubule epithelial cells and the development of kidney stone. This research investigated the roles of ADAM17 (A Disintegrin and Metallop...

Interpretable Machine Learning for Predicting Radiation-Induced Hypothyroidism in Head and Neck Cancer: A Dual-Center Retrospective Study

Background/Objectives: Radiation-induced hypothyroidism (RIHT) is a frequent complication in head and neck cancer (HNC) patients following radiotherapy, significantly impacting quality of life. This study aimed to develop and validate an interpretable machine learning model for p...

TET1-mediated DNA demethylation and transcription activation of MRPS17 induces lung adenocarcinoma through PI3K-AKT-mTOR pathway

Lung adenocarcinoma (LUAD), characterized by its complex molecular heterogeneity and resistance to both conventional and targeted therapies, poses significant therapeutic challenges. Therefore, the identification of novel molecular targets is crucial for enhancing therapeutic str...

Metabolomic Profiling of Telomere Length: Associations with Aging-related Phenotypes and Modifiable Lifestyle Factors in Chinese Older Adults

BACKGROUND: Telomere length (TL) is a well-established biomarker of cellular senescence, yet the metabolic profile of TL and its associations with aging-related phenotypes and responses to modifiable lifestyle factors remain unclear. METHODS: TL was measured using quantitative re...

A phase III clinical trial of PXT3003 in Chinese patients with Charcot-Marie-Tooth disease type 1A

Charcot-Marie-Tooth disease type 1A (CMT1A) is the most common inherited peripheral neuropathy and currently lacks disease-modifying therapy. PXT3003, a low-dose oral combination targeting PMP22 overexpression, has shown efficacy in two trials, while one recent confirmatory trial...

DMFF: a deep learning-based multi-omics fusion framework for survival prediction and subtype classification in breast cancer

Intra-tumor molecular heterogeneity contributes substantially to survival differences among patients with breast cancer. Although deep learning-based multi-omics integration has shown promise for prognostic modeling, existing approaches may be affected by information leakage duri...

Initial Clinical Experience with Percutaneous Endocardial Septal Pulsed Field Ablation in Hypertrophic Obstructive Cardiomyopathy: A First-in-Human Case Series

Background: Pulsed field ablation is a nonthermal ablation modality with a potentially favorable tissue selectivity profile. However, its application in septal reduction therapy for hypertrophic obstructive cardiomyopathy remains unexplored clinically. We investigated the feasibi...

ViroSeek: a viral detection pipeline for second-generation sequencing

Abstract Arbovirus emergences represent a rising public health issue and are exacerbated by climate change and globalization. Virome analysis has become a key approach for monitoring and managing infectious diseases, yet existing tools often remain technically complex and inacces...

Single‐atom Pt‐N‐C nanozyme targets Rara/Wnt/β‐catenin axis for diabetic cardiomyopathy treatment

Abstract Background and Purpose Diabetic cardiomyopathy (DCM) lacks effective therapies because of complex mechanisms. This study aims to develop a single‐atom nanozyme for integrated antioxidant and signalling regulation in DCM. Experimental Approach A graphene quantum dot‐templ...

A Randomized Placebo-Controlled Trial of HTD1801 Monotherapy in Participants With Type 2 Diabetes

OBJECTIVE: The safety and efficacy of HTD1801 versus placebo were evaluated in participants with type 2 diabetes inadequately controlled with diet and exercise. RESEARCH DESIGN AND METHODS: Key entry criteria of this phase 3, randomized, placebo-controlled trial included type 2 d...