Harbin Medical University

A vascular calcification model enabled by an ex vivo vascular calcification perfusion system

Vascular calcification is a major feature of cardiovascular disease, but mechanistic studies are limited by slow and variable animal models and by ex vivo systems that insufficiently reflect physiological flow. Here, we established an ex vivo vascular calcification perfusion syst...

Protocol for the ACTIVE trial: a multicentre, open-label, cluster-randomized controlled trial of a quality improvement programme for older adults with hip fracture in resource-limited hospitals in China

Aims The primary aim of the Action on Hip Fracture Management Quality Improvement (ACTIVE) trial is to evaluate whether a context-tailored quality improvement programme improves health-related quality of life at 120 days after hospital admission, among adults aged 65 years or old...

Targeting NIK-mediated microglial polarization: a novel therapeutic strategy for diabetic retinopathy

Abstract Background Diabetic retinopathy (DR) is a sight-threatening microvascular complication characterized by blood-retina barrier (BRB) disruption. While inflammation is central to early DR, the role of the non-canonical NF-κB pathway remains poorly understood. Methods We est...

Stroke survivors’ health priorities and targeted interventions in home-based post-discharge rehabilitation

<title>Abstract</title> Background This study aimed to describe health problems of the stroke survivors and the corresponding nursing interventions implemented during 12-week home-based post-discharge rehabilitation. Methods This was a descriptive secondary analysis within the co...

Fuzuloparib in combination with apatinib versus fuzuloparib alone for recurrent ovarian cancer: a randomized, open-label, phase 2 trial

A randomized, open-label, phase 2 trial assessed fuzuloparib (a PARP inhibitor) plus apatinib (a vascular endothelial growth factor receptor [VEGFR] inhibitor) versus fuzuloparib alone in patients with recurrent ovarian cancer (ROC). Patients with ROC who had failed ≥ 2 lines of...

Development of a urine-based DNA methylation assay for early endometrial cancer detection: a multicenter diagnostic study

Endometrial cancer (EC) incidence is rising globally, yet diagnosis still depends on invasive procedures, which limit accessibility and delay early detection. A noninvasive, accurate, and accessible diagnostic assay is urgently needed to enable early EC detection. In this multice...

Contrast-enhanced high-resolution magnetic resonance imaging for predicting recanalization in non-acute middle cerebral artery occlusion

The potential predictive value of contrast-enhanced high-resolution magnetic resonance-vessel wall imaging (MR-VWI) for endovascular recanalization in patients with non-acute middle cerebral artery (MCA) occlusion remains unclear. We retrospectively enrolled consecutive patients...

Programmable multifunctional microrobots for synergistic cuproptosis-immunotherapy

Abstract Oral microrobots as drug carriers have shown great promise in enhancing the therapeutic efficacy of colorectal cancer (CRC). However, existing platforms frequently lack the programmable temporal precision required to execute complex, multi-stage dosing regimens. Here, we...

Machine learning-based prediction of postoperative restenosis risk following direct repair of paediatric coarctation of the aorta

OBJECTIVES: Coarctation of the aorta is a congenital cardiovascular disease with focal aortic luminal narrowing, and paediatric patients face a high postoperative restenosis risk. This study aimed to develop and validate an interpretable machine learning model for early predictin...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Dual Regulation of ACSL3 by TRIM33-Mediated Ubiquitination and NBR1-Dependent Autophagy: A Therapeutic Target for Cerebral Ischemia-Reperfusion Injury

Background: Cerebral ischemia-reperfusion injury (CIRI) is a key contributor to stroke-related neurological damage, but the functional interplay between autophagy and ferroptosis—two critical pathological processes—remains poorly understood. Methods: Using oxygen-glucose deprivat...

Yes-associated Protein Is Involved in Tubular Epithelial Cell Apoptosis and Renal Tissue Damage in Early Sepsis-Associated Acute Kidney Injury

Abstract Sepsis-associated acute kidney injury (SA-AKI) is a distinct form of acute kidney injury in critically ill patients. It is characterized by tubular epithelial cell damage and apoptosis. The Hippo-Yes-associated protein (YAP) pathway plays dual roles in renal injury and r...

Prevalence of Keshan disease at the township level in China: a cross-sectional study

Keshan disease (KD), an endemic myocardiopathy with unclear etiology, lacks primary preventive measures. This study aimed to assess the prevalence of KD at the township level using spatial epidemiology, elucidate its distribution characteristics for further precision classificati...

U-Shaped Association Between Left Ventricular Dimension and Mortality in Patients With Heart Failure

Importance Left ventricular structural assessment is fundamental in heart failure (HF). However, the independent prognostic value of left ventricular size beyond its association with ejection fraction remains poorly defined in real-world, large-scale populations. Objective To inv...

Chitosan–Unconjugated Bilirubin Microspheres Alleviate Dysbiosis, Immune Dysregulation, and Intestinal Barrier Damage in Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease marked by immune dysregulation, microbiota imbalance, and intestinal barrier damage. Unconjugated bilirubin (UCB) shows promise in treating UC due to its anti-inflammatory properties but is limited by poor solubility...

Chlorambucil-LoadedNanomicelles against HepatocellularCarcinoma

Abstract For hepatocellular carcinoma (HCC) therapy, an NQO1-responsive chlorambucil-loaded nanomicelle (CLB-AZO-mPEG5) was designed and synthesized to overcome the poor water solubility of chlorambucil and to explore its mechanism against HCC. CLB-AZO-mPEG5 was constructed by co...

Magnetotactic bacterial-reprogrammed TCR-macrophages for durable anti-tumor photoimmune therapy

Macrophage have shown great promise in the clinical treatment for head and neck cancer (HNC). However, macrophage therapies confront significant hurdles due to a deficiency of tumor-specific targets and tumor resistance. Herein, we report the development of a magnetotactic bacter...

Associations of key diet-quality indexes with trajectory of multimorbidity: a prospective study in the UK Biobank

Dietary patterns have been associated with the morbidity and mortality of individual non-communicable diseases(NCDs). However, the impacts of baseline dietary patterns among the initially healthy population on the progression from healthy to first non-communicable disease (FNCD),...

Pathways to medication adherence: a configurational analysis of psychiatric symptoms and medication attitude in patients with schizophrenia spectrum disorder receiving long-acting injectable antipsychotics

Medication non-adherence affects nearly half of patients with schizophrenia spectrum disorder and is associated with relapse and hospitalization. Long-acting injectable (LAI) antipsychotics may improve adherence, but their effectiveness likely depends on interactions between spec...

Latent profiles of health empowerment and associated factors among older adults hospitalised with stroke: a single-centre cross-sectional study

This study aims to explore the health empowerment of elderly ischemic stroke patients in China and analyze its associated factors. Ischemic stroke patients hospitalized in the Department of Neurology and Rehabilitation of a tertiary hospital in Daqing from June 2025 to March 2026...