Harbin Medical University

Association of serum 25-hydroxyvitamin D and physical frailty with cardiovascular health in US adults

Evidence on the association between cardiovascular health (CVH) and frailty remains limited, and the role of serum 25-hydroxyvitamin D (25(OH)D) in this relationship is not fully understood. This study aimed to examine the association between frailty and CVH and to investigate th...

Neutrophil to Lymphocyte Ratio and Neurological Outcome in Ischemic Stroke at 4.5 to 24 Hours: A Post Hoc Analysis of TRACE-III Trial

Whether neutrophil to lymphocyte ratio (NLR), as a marker of increased inflammatory response, modifies the efficacy and safety of tenecteplase is uncertain in patients 4.5–24 h after stroke onset. We investigated this in the Tenecteplase Reperfusion Therapy in Acute Ischemic Cere...

Eudesmane Sesquiterpenoids from Dregea Volubilis Suppress Kidney Stones via Akt Signalling to Inhibit Oxalate Biosynthesis in Drosophila

Abstract Dregea volubilis has long been used in traditional medicine for the treatment of urolithiasis, yet its bioactive constituents and molecular mechanisms remain largely undefined. Here, molecular networking-guided UPLC-ESI-MS/MS analysis enabled the isolation of ten sesquit...

Peritumoral Malignant Cellular Foci Performs Better Than Tumor Budding and Poorly Differentiated Cluster in Risk Stratification of Lymph Node Metastasis in pT1 Colorectal Cancer

As biomarkers separated by the arbitrary 5-tumor-cell cutoff at the tumor invasive front, tumor budding (TB) and poorly differentiated clusters (PDC) are recognized as high-risk factors for lymph node metastasis (LNM) in pT1 colorectal cancer (CRC). Nonetheless, relevant findings...

Targeted Perturbation of Mitochondrial Energy Metabolism via Thermoelectric Nanoflowers for Enhanced Cuproptosis Echoed With Immunotherapy

ABSTRACT Cuproptosis, a novel anti‐cancer mechanism, holds significant potential for triggering sequential immunotherapy to enhance anti‐cancer efficacy. However, this cascade effect is often limited by copper efflux mechanisms mediated by the copper‐transporting ATPase (ATP7B),...

Electronic Interactions in Co/Cu Biotomic Nanozymes for Catalytic Eradication of Gram‐Positive Bacterial Biofilms

ABSTRACT Biofilm‐associated infections caused by Gram‐positive pathogens remain highly resistant to conventional antibiotic therapy due to restricted drug penetration and persistent inflammatory microenvironments. Inspired by the catalytic versatility and biocompatibility of coba...

Distinct prognostic patterns of inflammation nutrition indices in female gastric cancer patients with different anemia statuses and construction of an XGBoost predictive model

Preoperative anemia is common in gastric cancer and may adversely affect patient outcomes, particularly among women. This study aimed to evaluate the prognostic significance of anemia and to construct a machine learning model based on inflammation–nutrition-related indices for in...

Interpretable machine learning for identifying mild cognitive impairment among Chinese patients with obstructive sleep apnea: a multicenter cross-sectional study

Mild cognitive impairment (MCI) is clinically relevant in obstructive sleep apnea (OSA). We developed and externally validated an interpretable machine-learning model for concurrent clinically defined MCI to support prioritization for formal cognitive assessment rather than diagn...

Multi‐Omics Integration Reveals Metabolic Reprogramming and EMT ‐Driven Metastasis in Triple‐Negative Breast Cancer

ABSTRACT Triple‐negative breast cancer (TNBC) is an aggressive subtype with high metastatic potential and poor prognosis, yet the molecular mechanisms driving metastasis remain incompletely understood. Here, we performed integrated transcriptomic, metabolomic, and imaging mass cy...

RBMS1 Contributes to Early Arteriovenous Fistula Neointimal Remodeling Through Modulation of VSMC Phenotypic Responses

ABSTRACT Arteriovenous fistula (AVF) creation initiates stage‐dependent remodeling of the venous outflow tract. Neointimal hyperplasia is a common component of this response, but its post‐transcriptional regulation remains unclear. Here, analyses of human AVF datasets and tissue...

Single-cell transcriptome analysis reveals onco-fetal reprogramming with implications for drug resistance and clinical outcome

Onco-fetal reprogramming of the tumor ecosystem induces fetal-like characteristics, leading to tumor growth and malignant progression. Here, we develop a robust computational pipeline to systematically identify onco-fetal (OF) cells, using single-cell transcriptomic data from cor...

gutMDisorder v3.0: an updated database for dysbiosis of the gut and oral microbiota in phenotypes and interventions

Microbiota plays an essential role in host health, and dysbiosis of microbial communities has been widely associated with diverse phenotypes and intervention responses. With the rapid development of microbiome research, microbiome studies are no longer restricted to gut-derived s...

Mapping the Tissue Architecture and Endothelial‐ PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

ABSTRACT Hepatic angiomyolipoma (HAML) is a rare variant of perivascular epithelioid cell neoplasms (PEComas). Unlike its more common renal angiomyolipoma (RAML), the unique spatial microenvironment of HAML and its specific progression mechanisms remain poorly characterized. Here...

Sex‐Specific Digital Phenotyping of Lower Urinary Tract Symptoms: A Cross‐Sectional Study of 1586 Adults From 35 Centers in China

ABSTRACT Background and Purpose Lower urinary tract symptoms (LUTS) represent a complex clinical syndrome with significant sexual dimorphism. Traditional “one‐size‐fits‐all” management often overlooks intra‐sex phenotypic heterogeneity. This study utilized unsupervised machine le...

Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients

ABSTRACT Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug‐induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (E...

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients

Genomic or transcriptomic sequencing guides the precision of cervical cancer (CC) diagnosis; however, the molecular profile of Asian patients remains poorly understood. We established a comprehensive multi-omics cohort comprising 112 tumor-normal adjacent tissue pairs from Chines...

Synthesis, Preclinical Evaluation, and Clinical Application of the FAPI‐Dimer Based on the LARM Platform

ABSTRACT Fibroblast activation protein (FAP) is a promising pan‐tumor target for theranostics, but current FAP‐targeted radioligands are limited by insufficient tumor retention and suboptimal therapeutic doses. To address these challenges, we developed a novel LARM platform and s...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Oral small-molecule GLP-1 receptor agonist safiglipron in early type 2 diabetes: a randomized, double-blind, placebo-controlled trial

Abstract Safiglipron is an oral small-molecule glucagon-like peptide-1 (GLP-1) receptor agonist administered without fasting or dietary restrictions. We evaluated its efficacy and safety in OUTSTAND-1, a phase 3, multicenter, randomized, double-blind, placebo-controlled trial at...

Hydrogen gas alleviates osteoarthritis by inhibiting oxidative stress, apoptosis, inflammation, and extracellular matrix catabolism via the Nrf2/HO-1/NOX4 signaling pathway

Osteoarthritis (OA) is a chronic degenerative and debilitating disease. Reactive oxygen species (ROS) and oxidative stress play key roles in OA. NADPH oxidase 4 (NOX4) represents a major ROS source in chondrocytes. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) activa...