Harbin Medical University

The study of selective percutaneous pulmonary artery denervation guided by high-frequency stimulation for monocrotaline-induced porcine pulmonary arterial hypertension

Percutaneous pulmonary artery denervation has recently emerged as a potential therapeutic approach for pulmonary arterial hypertension (PAH). This study aims to investigate the feasibility of selective pulmonary artery denervation guided by high-frequency stimulation mapping. Fif...

Prediction of lymph node metastasis in colorectal cancer based on clinical data, body composition, and radiomics

Abstract Objective To develop and validate a positron emission tomography/computed tomography (PET/CT)-based model integrating clinical variables, body composition indices, and radiomics features for predicting lymph node metastasis (LNM) in colorectal cancer (CRC). Materials and...

A New Perspective on the Regulation of Microglia-Mediated Inflammation in Diabetic Retinopathy: Mechanisms of NLRP3 Inflammasome Activation and Therapeutic Strategies

Diabetic retinopathy (DR) is among the most common complications of diabetes mellitus and is characterized by microangiopathy and neurodegeneration. Microglia constitute a resident immune population in the central nervous system (CNS) and play crucial roles in regulating retinal...

The stroke crisis in ageing societies: global trends, risk factors, and clinical validation

Stroke remains a major global public health challenge, particularly among the elderly population. This study aims to integrate MIMIC-IV clinical data with GBD 2021 data to analyse epidemiological trends and regional differences in stroke among people aged 70 and above, identify k...

Predictive value of maternal serum occludin for neonatal respiratory distress syndrome in spontaneous preterm birth

OBJECTIVE: This study investigates maternal serum occludin and human leukocyte antigen G (HLA-G) profiles across preterm birth subtypes and their predictive value for neonatal respiratory distress syndrome (NRDS). METHODS: This retrospective analysis was conducted at Tianjin Cent...

SRSF1 Maintains Sertoli Cell Proliferation and Survival by Regulating Alternative Splicing in Coordination With DDX5 and RBMX / RBMXL1

Sertoli cells provide essential structural and nutritional support for germ cell development and play critical roles in spermatogenesis. Post-transcriptional regulation exerts important functions in Sertoli cells. Complex alternative splicing processes exist in Sertoli cells. Thi...

Drug-drug Interaction Between Alpinetin and Glimepiride and its Potential Mechanism in Rats

Given that alpinetin possesses hypoglycemic and cardioprotective properties, it holds potential for co-administration with the antidiabetic agent glimepiride. The aim was to evaluate the impact of alpinetin on the pharmacokinetics and hypoglycemic efficacy of glimepiride, thereby...

Interpretable laboratory-trajectory phenotypes for risk stratification of in-hospital critical events in cancer inpatients

Hospitalized cancer patients accumulate dozens of routine laboratory results within the first week of admission, but these are typically used only to flag individual abnormal values, and interpretability is a prerequisite for the bedside adoption of any clinical decision-support...

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma (ESCC); however, the underlying mechanisms and associated biomarkers that determine treatment response remain unclear. Objective We delineate the mechanism...

Implementation of an emergency nursing pathway reduces emergency department length of stay in trauma

Timely, organized emergency care is critical for patients with severe trauma, particularly in primary hospitals where resources and workflows may be constrained. This study evaluated the effect of implementing an emergency nursing pathway (ENP) on emergency management of injured...

Helicobacter pylori genotypes, virulence and antibiotic resistance patterns among outpatients with gastric diseases in representative urban-rural areas of Yunnan, China

Abstract Background The epidemiological and molecular characteristics of Helicobacter pylori ( H. pylori ) across different gastric lesion stages remain unclear. This study aimed to analyse H. pylori positivity, phylogenetic lineages, virulence genotypes, and antibiotic resistanc...

Genetic and pharmacological evidence linking CB1R signaling to hippocampal GABAergic dysfunction in ASD mouse model

Autism spectrum disorder (ASD) is a neurodevelopmental disorder increasingly linked to disrupted GABAergic inhibition and altered excitatory-inhibitory balance. Cannabinoid receptor 1 (CB1R), enriched on GABAergic interneurons, modulates inhibitory tone. Whether CB1R dysfunction...

Secondhand smoke exposure in never-smokers

Chronic kidney disease (CKD) is a major global health burden, yet the association of secondhand smoke (SHS) exposure with CKD among never-smokers remains incompletely characterized. This cross-sectional and prospective cohort study analyzed 13,276 never-smoking adults from the Na...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

Breaking the Lipid Bottleneck: A Mitophagy‐Driven Nanoregulator Amplifies Ferroptosis for Colorectal Cancer Immunotherapy

ABSTRACT Colorectal cancer (CRC) therapy is severely constrained by the immunosuppressive tumor microenvironment (TME). This study presents a TME‐responsive nanometabolic regulator, ZnO 2 @Fe@HA (ZFH), designed to bridge mitochondrial dysfunction, lipid reprogramming, and ferropt...

Neoadjuvant therapy and minimally invasive surgery for pancreatic cancer: current evidence and surgical decision-making

Neoadjuvant therapy (NAT) is standard care for borderline resectable and locally advanced pancreatic cancer (PC). While minimally invasive surgery (MIS) is increasingly utilized post-NAT, surgical decision-making and technical feasibility remain debated. This review evaluates cur...

Prevalence and risk factors of comorbidities among Chinese older people living with HIV/AIDS: a cross-sectional study

With population aging among people living with HIV/AIDS (PLWHA), comorbidity has become a prominent challenge for long-term care. However, evidence on its prevalence and associated factors in Chinese community settings remains limited. We conducted a cross-sectional study among P...

Mortality-trained MRI brain age acceleration mediates sex-specific associations between health-related phenotypes and incident dementia

Abstract Background Brain age acceleration (BAA) has emerged as a promising neuroimaging marker of brain health and neurodegeneration. However, most existing brain age models are trained to predict chronological age, which may not be the most clinically relevant target. In this s...

The abscopal effect and systemic immune reprogramming: from phenomenon to therapeutic design

The classical abscopal effect is defined here as objective regression of a verified non-irradiated tumor lesion following local radiotherapy. An immune abscopal phenomenon denotes a prespecified, reproducible immune change within such a lesion that is attributable to the local in...

Thrombus-Targeted and Reactive Oxygen Species-Responsive Apigenin Liposomes for Ischemic Stroke

Abstract Ischemic stroke remains a leading cause of mortality and long-term disability, while current therapies inadequately address oxidative stress, mitochondrial dysfunction, and blood–brain barrier (BBB) disruption during ischemia and reperfusion. Here, we developed DPCT@LIP-...