Hainan Medical University

A community-based online machine learning platform for predicting rapid decline in kidney function: a nationwide cohort study

Rapid decline in kidney function (RDKF) is an early and modifiable precursor of chronic kidney disease, yet proactive risk identification remains limited in community-based populations. This study aimed to develop, validate, and deploy an interpretable machine learning model to p...

Species discordance in diatom testing for drowning diagnosis: a biological passive sampling hypothesis with forensic implications

Diatom testing is a key technique for forensic drowning diagnosis, yet species discordance between diatom taxa in victim tissues and water samples from the recovery site remains a major medico-legal challenge, often misattributed to technical errors or post-mortem contamination....

Diversity and Bioprospection of Functional Proteins from Sea Anemone Heteractis magnifica Based on Multi-Omics Approach

Sea anemone venom has attracted increasing attention in biomedical research due to its multifarious compounds with biological activities. Although the venom is predominantly made up of proteins, the diversity and complexity of these proteins remain poorly understood. In this work...

Long-term body roundness index profiles and incident diabetes in middle-aged and older Chinese adults: a longitudinal analysis of CHARLS 2011–2020

Higher body roundness index (BRI) is associated with diabetes, but trajectory classes derived from a small number of repeated measurements may primarily reflect average BRI level. We examined whether sustained BRI profiles were associated with incident diabetes and, secondarily,...

Single-cell transcriptomics uncovers HPV-driven immune evasion and establishes a TAB2-based prognostic signature in cervical cancer

Background Persistent human papillomavirus (HPV) infection is a key driver in cervical cancer, yet the molecular mechanisms linking HPV to immune escape remain incompletely understood. Methods We integrated single-cell RNA sequencing (scRNA-seq), bulk transcriptome, and clinical...

Magneto‐NIR‐II‐Programmed Cascade Nanozymes Unlocking Blood–Brain Barrier Translocation and Autophagic Resistance in Glioblastoma

ABSTRACT Glioblastoma (GBM) remains a highly aggressive central nervous system malignancy, and its treatment is hindered by poor drug accumulation across the blood–brain barrier (BBB) and autophagy‐mediated repair. To address these barriers, rare‐earth‐doped Nd 0.02 Fe 2.98 S 4 @...

Analysis of the prevalence of positivity for tuberculosis infection in formalin-fixed paraffin-embedded tissue

Abstract Background The objective of this study was to analyze the tuberculosis(TB) positivity rate of formalin-fixed paraffin-embedded (FFPE) tissue samples, to explore the difference between the positivity rates of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (E...

First detection of Leishmania infantum in dogs and wild-caught Culicoides oxystoma in Hainan Province, Southern China

Leishmaniases are neglected parasitic diseases expanding globally. In China, Leishmania infantum , which isendemic in the west, has reemerged and spread to the central part of the country, raising concerns about further potential expansion. Given limited data from southern China,...

Assessing Cultivated Land Abandonment in Hainan Island: Spatio-Temporal Differentiation and Driving Mechanism

Cultivated land abandonment poses a growing threat to regional food security and sustainable land resource allocation in tropical island regions, making the accurate identification of its spatio-temporal characteristics and driving mechanisms an urgent research priority. This stu...