Hainan Medical University

Targeting MDA5 induces immunogenic cell death and promotes anti-tumor immunity

Identifying targets to enhance tumor immunity is an urgent need. Although nucleic acid sensors play critical roles in promoting tumor immune clearance, their exceptionally low mutation rate in cancers suggests potential unexplored roles in tumor progression. Here, we demonstrate...

Regarding “Increased Elbow Valgus Torque During Pitching Is Not a Risk Factor for Medial Elbow Injuries in Young Baseball Pitchers: A Prospective Cohort Study”

We read with great interest the study by Saito et al.1 and commend the authors for addressing an important and clinically relevant question in youth throwing injury prevention. However, we believe that several important aspects were insufficiently addressed, and we respectfully o...

Mitochondrial Protection and Neural Repair via ROS‐Responsive Biomimetic Nanoparticles in Intracerebral Hemorrhage

ABSTRACT Intracerebral hemorrhage (ICH)‐induced secondary brain injury is driven in part by oxidative stress, blood‐brain barrier disruption, mitochondrial dysfunction, and neuronal loss. Here, we developed a brain endothelial cell membrane‐coated ROS‐responsive biomimetic nanopl...

Effects and social design features of physical activity interventions on loneliness and subjective well-being in older adults: a systematic review

Physical activity is promoted in later life, yet its capacity to reduce loneliness or improve subjective well-being remains uncertain when social contact is incidental rather than intentionally designed. This review synthesised controlled intervention evidence and examined how so...

Integrated multi-omics analysis reveals the molecular landscape and therapeutic strategies in Chinese cervical cancer patients

Genomic or transcriptomic sequencing guides the precision of cervical cancer (CC) diagnosis; however, the molecular profile of Asian patients remains poorly understood. We established a comprehensive multi-omics cohort comprising 112 tumor-normal adjacent tissue pairs from Chines...

Preliminary metabolomic and genomic exploration with gene-expression validation in multiple symmetric lipomatosis

Abstract Background Multiple symmetric lipomatosis (MSL) is a rare disorder of fat metabolism with an incompletely understood pathogenesis and limited treatment options. This preliminary study explored metabolite differences and genomic characteristics in paired lesional and adja...

Tactical Paralysis: The Interplay Between Chikungunya Virus and Host Mitochondrial Dynamics in Immune Evasion and Metabolic Remodeling

Chikungunya virus (CHIKV) is an expanding alphavirus causing acute febrile illness, yet its most debilitating signature remains the refractory chronic arthralgia persisting for months or years. While traditional paradigms focused on viral-mediated host shutoff, emerging evidence...

Deciphering the AGEs-RAGE Signaling Network in Diabetes-Associated Periodontitis: Pathogenic Mechanisms and Emerging Targeted Therapies

Objectives: To summarize the role of the AGEs-RAGE axis in diabetes-associated periodontitis and evaluate potential targeted therapies. Materials and Methods: Recent literature on molecular mechanisms and therapeutic strategies involving the AGEs-RAGE pathway in diabetic periodon...

Artificial Intelligence in Dentistry: Integrated Applications and Specialty-Specific Advances

Artificial intelligence (AI) is transitioning from a supportive tool to a core component of clinical decision-making in dentistry. This review synthesizes advances in deep learning and machine learning for oral disease diagnosis, orthodontic treatment prediction, pediatric oral h...

Interpretable machine learning-based model for predicting postoperative urinary tract infection after minimally invasive surgery for upper urinary tract calculi: development and external validation

This study sought to develop and externally validate an interpretable machine learning–based model to predict the risk of urinary tract infection (UTI) following minimally invasive surgery (MIS) in patients with upper urinary tract calculi. Clinical data from patients suffering u...

Osm-9/OCR-2 can reverse the grk-2 mutation inducing swimming obstacle in C. elegans

Caenorhabditis elegans (C. elegans ) has become a pivotal model organism in unraveling the regulatory mechanisms behind rhythmic movement due to its characteristic rhythmic movement pattern. This study aims to explore the mechanism by which the grk-2 mutation causes swimming defi...

Maternal and fetal risk factors for hypospadias: a hospital-based case-control study in Southern China

Hypospadias is a frequent congenital anomaly in male infants, defined by the urethral meatus opening on the ventral surface of the penis. Although its causes have been examined for many years, the underlying aetiology in most affected children remains unclear. Maternal factors su...

Cell and tissue xenotransplantation: clinical purpose determines translational strategy and therapeutic endpoints

Solid organ xenotransplantation is moving into early clinical use, whereas living xenogeneic cells and tissues are being developed for distinct therapeutic tasks. Product-based discussions can obscure differences in required functional duration, immune exposure, consequences of p...

Features and a specific pattern of cerebral perfusion in patients with Lewy body dementia: Diagnostic ability and clinical correlations

Cerebral perfusion changes have been observed in patients with both dementia with Lewy bodies and Parkinson’s disease dementia. In this study, features of cerebral blood flow (CBF) and a specific perfusion pattern measured using arterial spin labeling (ASL) MRI for Lewy body deme...

Timing of surgery for a melioidosis-associated abdominal aortic pseudoaneurysm: a case report

BACKGROUND: Melioidosis is a tropical infectious disease caused by Burkholderia pseudomallei. Although vascular involvement is rare, melioidosis-associated abdominal aortic pseudoaneurysm can rapidly progress and carries a high risk of rupture and mortality. Due to nonspecific ea...

Multi-omics integration of gut microbiome and plasma metabolome in MASLD: a Hainan-based observational case-control study

Metabolic dysfunction-associated steatotic liver disease (MASLD) affects nearly one-quarter of adults worldwide and has emerged as a leading cause of chronic liver disease. This study aimed to characterize gut microbial composition and plasma metabolite alterations in MASLD patie...

Triglyceride-glucose-sarcopenia index and risk of cardiovascular diseases in multinational prospective cohorts

Abstract Background Muscle tissue dictates insulin-driven glucose uptake; muscle dysfunction paired with insulin resistance can trigger a compound cardiometabolic failure. However, whether this dual pathology confers incremental long-term cardiovascular risk stratification is yet...

Sleep quality is associated with gut microbiome signatures of hyperuricemia in Chinese elderly adults: a community-based case–control study

Hyperuricemia (HUA) has become a global health issue due to its rapidly increasing prevalence. Growing evidence from population and animal studies suggests that gut microbial dysbiosis and lifestyle changes are involved in serum uric acid metabolism. However, most existing studie...

Multi-omics analysis reveals TCA cycle and mitochondrial metabolic remodeling associated with astragaloside IV-mediated cardioprotection

Diabetic cardiomyopathy (DCM) is a major complication of diabetes and is closely related to metabolic dysfunction. Astragaloside IV (ASIV), as an effective component of Astragalus membranaceus (Fisch.) Bunge, which is both edible and medicinal, plays an important role in the prev...

Cross-sectional assessment of cerebral hemodynamics in individuals with type 2 diabetes and orthostatic hypotension

This cross-sectional study investigated the cerebral hemodynamics of patients with type 2 diabetes (T2DM) with varying orthostatic hypotension (OH) statuses. Using transcranial Doppler (TCD), we assessed cerebral blood flow velocities (CBFv) and pulsatility index (PI) during a su...