Hainan Medical University

Fabrication and in Vitro Evaluation of Photothermal‐Responsive Nanofibers Loaded With Tannic Acid‐Copper Complexes

ABSTRACT The excessive use of antibiotics has led to an increasingly serious problem of bacterial resistance, which poses challenges for the clinical treatment of skin wound infections and urgently requires the development of new antibacterial strategies. This study synthesized t...

Comparing the efficacy of bronchial artery chemoembolization combined with anlotinib versus anlotinib alone in the treatment of advanced non-small cell lung cancer

To compare the clinical effectiveness and safety of addition of anlotinib to bronchial artery chemoembolization (BACE) compared to anlotinib alone in the treatment of stage IIIA-IIIB non-small cell lung cancer (NSCLC) with no mutated driver genes. The clinical data of patients wi...

Intranasal delivery of BDNF-enriched small extracellular vesicles ameliorates cognitive impairment and Alzheimer’s disease-like pathology in APP/PS1 mice

Alzheimer’s disease (AD), the leading cause of dementia, still lacks broadly effective disease-modifying therapies. Here, we engineered brain-derived neurotrophic factor (BDNF)-enriched small extracellular vesicles (BDNF-sEVs) from human induced pluripotent stem cell-derived mese...

Photoredox-Enabled Difluoromethylation Cyclization and Quinoxalin-2(1 H )-one Integration: Access to gem -Difluoro-Quinolines

Abstract Herein, a novel protocol for the photoredox-enabled intramolecular difluoromethylation cyclization and intermolecular domino quinoxalin-2(1H)-one integration is established. This version allows facile access to structurally diverse gem-difluoro-quinolines. A wide substra...

Optimal control of spiral waves in heterogeneous excitable media: non-monotonic efficacy of localized optogenetic inhibition

Structural heterogeneity stabilizes spiral waves in excitable media, yet how its spatial architecture, ranging from diffuse interstitial deposition to focal scar patterns, modulates the efficacy of localized optogenetic control remains poorly understood. Using a two-dimensional c...

Treatment of bleeding from endogenous heparin-like substances after traumatic injury with protamine: a case report

Abstract Background To provide reference for clinical treatment of trauma-induced coagulopathy. Persistent bleeding caused by endogenous heparin-like substances is difficult to identify and diagnose. This report describes the clinical manifestations and management of patients wit...

Contribution of social determinants of health to racial disparities in metabolic dysfunction-associated steatotic liver disease among US adults

Abstract Background Racial and ethnic disparities in metabolic dysfunction-associated steatotic liver disease (MASLD) persist in the US population. We studied the impact of social determinants of health (SDOH) on the likelihood of developing MASLD and explored the contribution of...

A Poly(lactic Acid)‐Porphyrin‐Cobalt Vaccine Adjuvant System Elicits Protein‐ or Peptide‐Specific Humoral and Cellular Immunity

ABSTRACT There is growing interest in vaccine adjuvant systems that are scalable, adaptable, and capable of stimulating humoral and cellular immune responses with recombinant protein or synthetic peptide immunogens. In this study, we introduced a “plug‐and‐play” nanoadjuvant syst...

T-cell–driven immune modulation in osteoarthritis: deciphering the hADSC–macrophage cross-talk

Abstract Osteoarthritis (OA) has traditionally been regarded as a mechanically driven degenerative joint disorder. However, recent advances in single-cell sequencing, spatial omics, and immunohistochemical analyses have revealed that OA is also characterized by persistent low-gra...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...

Identification of Senescence‐Associated β‐Galactosidase With Single‐Molecule Resolution

ABSTRACT The majority of human senescent cells exhibit overexpression of senescence‐associated β‐galactosidase (SA‐β‐gal), rendering this enzyme the most extensively utilized biomarker of senescence and a key prodrug target for intervening in aging. However, strategies for the au...

Communication support for older adults with age-related hearing loss in acute care settings

Age-related hearing loss is frequently overlooked in acute care settings despite its negative effects on communication, care experience and patient safety. This literature review synthesises recent evidence on interventions, practices and approaches relevant to supporting older a...

Recipient-driven and donor-driven determinants of delayed graft function in paired kidney transplantation: evidence from a Chinese cohort

Background Delayed graft function (DGF) is a frequent complication of kidney transplantations. When both kidneys from a single deceased donor are transplanted into two recipients, DGF outcomes may be discordant, affecting only one recipient, or concordant, affecting both recipien...

Fertility support needs of reproductive-age women based on the Kano model and ERG theory: a cross-sectional study

Amidst the declining fertility rate and population aging, providing effective fertility supports for reproductive-age women is urgently needed. Hence, understanding their fertility support needs is paramount. An observational design was implemented and the STROBE Checklist was ad...

Comparison of three interpretation criteria for [⁶⁸Ga]Ga-DOTATATE PET/CT in suspected pheochromocytoma and paraganglioma of the adrenal gland or retroperitoneal space

Pheochromocytomas and paragangliomas (PPGLs) frequently overexpress somatostatin receptor subtype 2 (SSTR2), making [ 68 Ga]Ga-DOTATATE PET/CT a promising functional imaging modality. However, the optimal interpretation criteria for distinguishing PPGL from non-PPGL lesions in cl...

A nose-to-brain circuit underlies anxiety regulation by nasal afferent frequency in mice

Slow nasal breathing alleviates negative moods, but the precise nose-to-limbic pathways and their causal contributions remain unclear. Here, we identify a pathway in mice from olfactory sensory neurons (OSNs) in the nasal cavity to mitral cells in the olfactory bulb (OB), then to...

Mental health knowledge-stigma profiles among primary healthcare workers involved in severe mental disorder management in Hainan, China

Under China’s Project 686 and the National Basic Public Health Service Program, primary healthcare workers play a central role in the community management of severe mental disorders. However, little is known about heterogeneity in mental health knowledge and perceived public stig...

Latent subtypes and gender differences in the comorbidity of depression and sleep disturbances among adolescents: insights from network analysis and latent profile analysis

This study aimed to explore potential subtypes, influencing factors, and gender differences in the associations between adolescent depression and sleep disorders. A cross-sectional study was conducted among adolescents utilizing the Center for Epidemiologic Studies Depression Sca...

The relationship between preoperative anxiety, self-efficacy, and positive coping style in lung cancer patients undergoing video-assisted thoracoscopic surgery: a cross-sectional study

Abstract Background Patients with lung cancer undergoing video-assisted thoracoscopic surgery (VATS) may experience preoperative anxiety arising from cancer-related uncertainty and surgery-related concerns. Although VATS is less invasive than conventional thoracotomy, patients ma...

Dysbiosis of gut fungi and bacteria in patients with HBV with low-level viremia compared with sustained virologic responders and healthy controls

Although bacterial dysbiosis in chronic hepatitis B (CHB) is well established, the role of the gut mycobiome-particularly its functional interplay with bacteria during virological remission versus treatment failure remains unexplored. In this study, the gut bacteriome and mycobio...