Guangzhou University of Chinese Medicine

Pseudo-trust behavior-based consensus methodology with asymmetric costs for social network group decision-making

In intelligent decision-making systems, the coupling effect of information fuzziness with multiple constraints-including social network restrictions, pseudo-trust behavior interference, and fairness imbalance, not only amplifies the positional divergences among decision-makers bu...

Osm-9/OCR-2 can reverse the grk-2 mutation inducing swimming obstacle in C. elegans

Caenorhabditis elegans (C. elegans ) has become a pivotal model organism in unraveling the regulatory mechanisms behind rhythmic movement due to its characteristic rhythmic movement pattern. This study aims to explore the mechanism by which the grk-2 mutation causes swimming defi...

Machine learning combined with multidimensional validation identifies SNCA and NR2F2 as key hubs implicated in paraquat and rotenone co-exposure-induced Parkinson’s disease

Combined exposure to pesticides, such as paraquat (PQ) and rotenone (Rot), is a significant risk factor for Parkinson’s disease (PD). However, the synergistic pathogenic mechanisms underlying their co-exposure remain largely elusive. This study aimed to elucidate the key molecula...

Baicalein Ameliorates Postmenopausal Osteoporosis With Iron Accumulation by Inhibiting Osteoclastogenesis via Nrf2 Activation

ABSTRACT Postmenopausal osteoporosis (PMOP) is frequently complicated by iron accumulation, which exacerbates bone loss. Baicalein, a natural flavonoid with iron‐chelating and antioxidant properties, has shown bone‐protective effects, but its role in iron‐overloaded PMOP remains...

Perioperative prediction of ideal postoperative recovery after kidney transplantation: a multicenter retrospective cohort study

Kidney transplantation is the preferred treatment for end-stage renal disease, but early postoperative outcomes remain heterogeneous. Textbook outcome (TO), a composite measure of an ideal postoperative recovery trajectory, has emerged as a meaningful indicator of surgical qualit...

Tenascin-C Promotes Fibroblast Pathogenic Features and is Associated with Synovial Inflammation in Rheumatoid Arthritis

Despite the recognized involvement of Tenascin-C (TNC), an extracellular matrix glycoprotein induced during chronic inflammation, in tissue remodeling and inflammatory disorders, its clinical significance and functional roles in rheumatoid arthritis (RA) remain incompletely under...

High tibial osteotomy for proximal tibial osteonecrosis with medial tibial plateau fracture in a patient with prior knee arthroscopy: a case report

High tibial osteotomy (HTO) is a well-established joint-preserving procedure for unloading the medial compartment of the knee. It has been applied in selected cases of spontaneous osteonecrosis or subchondral insufficiency fracture of the knee. However, the coexistence of proxima...

Tetrandrine-loaded manganese-doped ceria nanozyme for nebulized inhalation therapy of the ROS-driven inflammatory-fibrotic continuum

Pulmonary fibrosis (PF) and acute lung injury (ALI) represent mechanistically interrelated stages along a shared inflammatory-fibrotic disease continuum, both driven by dysregulated macrophage responses and reactive oxygen species (ROS)-mediated signaling. Effective intervention...

Structural and diffusion MRI markers of the choroid plexus and perivascular regions are associated with Alzheimer’s disease pathology and cognition

Abstract Background Choroid plexus (ChP) morphology and periventricular diffusion alterations have been implicated in Alzheimer’s disease (AD). However, whether ChP volume and the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provide complementar...

Remnant cholesterol predicts adverse clinical outcomes in patients with hypertension: a post hoc analysis of the ALLHAT

Background and purpose: Remnant cholesterol (RC) has been proposed to play a role in regulating the residual cardiovascular risk in individuals with atherosclerotic cardiovascular disease (ASCVD), yet the underlying mechanisms remain elusive. This study aimed to investigate the r...

Depressive Symptoms, sleep Disturbance, and Cardiometabolic Multimorbidity Among Adults With Arthritis: A Cross‐Sectional Analysis of NHANES 2013–2020

While the association between depressive symptoms and cardiometabolic disease is well established, the relationships among depressive symptoms, sleep disturbance, and cardiometabolic multimorbidity (CMM) in adults with arthritis remain insufficiently understood. This cross-sectio...

Modeling the Impact of Active Site Mutations on the Quenching Fate and Cyclization Depth of a Rare Oxidosqualene Cyclase

Abstract Oxidosqualene cyclases (OSCs) convert linear 2,3-oxidosqualene into diverse polycyclic triterpenoids. The precise control over highly reactive carbocation intermediates, particularly the ultimate quenching mechanism (deprotonation vs hydroxylation), remains a fundamental...

Follicular dendritic cell sarcoma in association with Castleman disease complicated by paraneoplastic pemphigus: a retrospective analysis of six cases

Abstract Background Follicular dendritic cell sarcoma (FDCS) arising from Castleman disease(CD) is an extremely rare entity. This study aimed to evaluate the detailed clinicopathological characterization, including histomorphology, immunohistochemical profiles, clinical presentat...

A review of power conversion and energy management technologies in rheumatoid arthritis diagnostic equipment

Purpose This study aims to investigate electrical energy management challenges across rheumatoid arthritis (RA) diagnostic devices, addressing a critical gap between large high-resolution imaging equipment and portable microsystems. The research seeks new insights into key power...

Prevalence and occupational risk factors of dry eye symptoms among Chinese healthcare workers

Healthcare workers (HCWs) in China are at a high risk of self-reported dry eye symptoms due to occupational exposures, yet population-based epidemiological data on this issue among Chinese HCWs remain scarce. This multicenter cross-sectional study aimed to quantify the prevalence...

Exploring key genes associated with metabolic cell death in ischemic stroke: a comprehensive analysis of single-cell, bulk transcriptome, and experimental validation

Metabolic cell death and ischemic stroke (IS) may be closely correlated. In this study, we identified key metabolic cell death-related genes (MCD-RGs) in IS, which may provide insight into ischemic injury and candidate targets for future therapeutic exploration. GSE163654, GSE306...

Targeted Inhibition of Intracellular Coxiella burnetii by Overcoming the Vacuolar Barrier with Autologous Exosomal Doxycycline

Abstract Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular bacterium that replicates within the Coxiella-containing vacuole (CCV), a lysosome-like compartment. The acidic microenvironment within the CCV impairs the activity of weak-base antibiotics s...

CD147 exacerbates ischemic brain injury and disrupts Wnt/β-catenin signaling and blood-brain barrier integrity

Abstract Ischemic stroke is a leading cause of death and disability, with limited therapies beyond reperfusion. CD147 (Basigin), upregulated after cerebral ischemia, participates in neuroinflammation, however, its precise contributions to blood-brain barrier (BBB) disruption and...

Shared oral microbiome signatures linking periodontitis and autoimmune thyroiditis: NHANES 2009–2012

Objective To examine the association between periodontitis severity and autoimmune thyroiditis (AIT) in a nationally representative US sample and to explore oral microbiome features shared between the two conditions.Methods We analyzed adults from NHANES 2009–2012 with complete p...

Mid-to long-term survival analysis following allograft fibular support for Japanese investigation committee type C non-traumatic osteonecrosis of the femoral head: a single-center retrospective cohort study

This study evaluated mid- to long-term femoral-head survival following allograft fibular support (AFS) for Japanese Investigation Committee (JIC) type C non-traumatic osteonecrosis of the femoral head (ONFH) at the pre-collapse or early-collapse stage and examined factors associa...