Guangzhou University of Chinese Medicine

Efficacy and safety of Shenfu injection on sepsis-induced myocardial dysfunction: a meta-analysis and trial sequential analysis

The efficacy and safety of Shenfu Injection (SFI) as an adjunctive treatment for sepsis-induced myocardial dysfunction (SIMD) remain uncertain despite preliminary investigations. Eight databases were searched for qualified randomized controlled trials (RCTs) from inception to 10...

A comparative study of large language models in responding to breast cancer–related questions

Abstract Breast cancer is one of the most common cancers among women worldwide. With advances in diagnostic and therapeutic technologies, more patients seek information about their condition. Large language models (LLMs) have attracted attention in healthcare for their ability to...

Sprayable hydrogel loaded with engineered fusion cellular vesicles for cancer recurrence suppression

Surgical resection often leaves residual lesions that lead to tumor recurrence and high mortality across various cancer types, a challenge that is particularly pronounced in oral squamous cell carcinoma. Herein, we developed a sprayable hydrogel loaded with fusion cellular vesicl...

Interpretable machine learning model for predicting the ICU readmission of patients after coronary intervention

To develop and validate an interpretable machine learning (ML) model integrated with inflammatory indicators for predicting ICU readmission in patients after coronary intervention (PCI/CABG). We used retrospective data from MIMIC-IV (training, 2196 patients) and MIMIC-III (extern...

Baseline airway dysfunction and small-airway abnormality burden are longitudinally associated with adverse ultradistal radial bone density outcomes in a 5-year cohort

Impaired pulmonary function has been linked to lower bone mineral density and higher fracture risk, but longitudinal evidence on airway dysfunction and subsequent peripheral bone-density outcomes remains limited. We investigated whether baseline airway dysfunction, FEV1/FVC, and...

An Injectable ROS‐Responsive Nanozyme Hydrogel Regulates the Uterine Microenvironment to Prevent Intrauterine Adhesions

ABSTRACT Intrauterine injury triggers a self‐reinforcing cycle of inflammation, oxidative stress, and fibrosis that culminates in intrauterine adhesions (IUA), severely impairing women's reproductive health. Current treatments, including hysteroscopic adhesiolysis combined with h...

Clinical practice guidelines for nephrotic syndrome: systematic assessment of their quality and the concordance between certainty of evidence levels and strength of recommendations

Clinical practice guidelines (CPGs) aim to provide appropriate clinical practice recommendations based on available evidence while acknowledging existing gaps and uncertainties. However, the quality of CPGs for nephrotic syndrome (NS) remains unknown, and the distribution of evid...

circBIRC6 regulates cisplatin resistance of choroidal melanoma via positively modulating ERK by sponging miR-503-3p

Abstract Background/AimscircRNA plays a key regulatory role in various human tumors. This study was carried out to investigate the molecular mechanism of circBIRC6 in the regulation of choroidal melanoma cisplatin (DDP) resistance. MethodsThe expression of circBIRC6 in choroidal...

IS 26 -mediated circular bla KPC transposon in ST2483 Pseudomonas aeruginosa

ABSTRACT The global spread of carbapenem-resistant Pseudomonas aeruginosa (CRPA) poses a critical clinical threat, with bla KPC as a key mobile carbapenem resistance gene. Here, we investigated a novel bla KPC-2 genetic element and its transmission in clinical ST2483 isolate PA10...

Merging artificial intelligence and retinal vascular geometric parameters: A novel tool for diagnosis and prognosis prediction of diabetic nephropathy

Abstract Background: Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The retinal microvasculature, as the only directly observable microvasculature, may reflect DN progression. This study aims to construct a non-invasive diagnostic and prognostic predic...

Breaking Alzheimer's Disease Barrier: The Role of Xanthoceras sorbifolia Bunge Oil in Gut‐Brain Axis and TLR4 /Myd88/ MAPK Pathway Inhibition

Alzheimer's disease (AD) is a progressive neurodegenerative disorder associated with cognitive decline and neuroinflammation. Xanthoceras sorbifolia Bunge oil (XSBO), a woody plant oil rich in bioactive fatty acids, has shown potential health benefits. This study aimed to investi...

Lateral internal sphincterotomy with skin grafting for chronic anal fissure: protocol of a multi-center randomized controlled trial

Abstract Background: Anal fissure, a prevalent anorectal disorder, is defined as a longitudinal tear in the anoderm distal to the dentate line.Chronicity develops in a substantial fraction of anal fissures despite initial conservative success, resulting in significant quality-of-...

Machine learning-based mapping of multimodal treatment allocations and prognostic implications of clinical concordance in non-small cell lung cancer

Machine learning models of non-small cell lung cancer (NSCLC) treatment usually examine one modality. We developed interpretable models of historical surgery, chemotherapy, and radiotherapy receipt in SEER. We assessed regional transportability and associations between observed t...

DUSP4 promotes anti-tumor CD8+ T cell function and boosts CAR-T cell efficacy in mouse colorectal cancer

The activation and function of CD8+ T cells, which are central for anti-tumor immunity, are tightly regulated by extracellular and intracellular signaling pathways. Dual-specificity phosphatases (DUSP), including DUSP4, dephosphorylate serine/threonine and tyrosine residues of pr...

YAP delactylation enhances therapy resistance in renal cell carcinoma

Abstract Lactylation is a novel lysine acylation modification, and its function and exact mechanisms remain unclear. The responsiveness to combined targeted and immunotherapy continues to be a major challenge in cancer treatment. Here, we discovered that lysine lactylation (Kla)...

Toeplitz-structured deep unfolding network for TomoSAR 3-D reconstruction

Urban area 3-D imaging is a key application of synthetic aperture radar (SAR). Classical compressive sensing-based tomographic SAR methods rely on iterative optimization, which is computationally expensive and sensitive to hyperparameter tuning, limiting its scalability for large...

Role of Life’s Essential 8 in the association of night shift work with cardiovascular disease and mortality: a prospective cohort study of UK Biobank participants

Background: Night shift work is linked to higher risks of cardiovascular disease (CVD) and mortality, but mechanisms remain unclear. Lifestyle, captured by the American Heart Association's Life's Essential 8 (LE8), may act as a modifiable mediator. We aimed to examine the associa...

Latent profile analysis of stigma and medical coping among patients with vaginitis: a cross-sectional study

Vaginitis is a common chronic condition among genital tract infections. Its sensitive anatomical location and tendency to recur not only impact individual health but also affect psychological well-being and coping strategies. This study aimed to identify latent profiles of stigma...

Mechanisms and therapeutic strategies of asthma: from bench to bedside

Asthma is a heterogeneous chronic airway disease arising from a complex interplay of genetic susceptibility and environmental exposures. Key pathobiological features include dysregulated immune responses (particularly type 2 inflammation), structural airway remodeling, and mucus...

An integrated bioinformatics analysis reveals that targeted activation of IL7R may reduce influenza A virus infection risk in patients with depression

Depression has been associated with increased susceptibility to influenza; however, the underlying mechanisms remain unclear. Mendelian randomization (MR) analysis was performed to assess the causal relationship between depression and influenza. Differential expression genes (DEG...