Guangzhou University of Chinese Medicine

Association of methylenetetrahydrofolate reductase C677T polymorphism with lacunar infarction: A systematic review and meta-analysis

Background: The association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and lacunar infarction (LI) remains inconclusive. Methods: The literature retrieval encompassed PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure, and Wa...

Oligodendrocyte Lineage Dysfunction in Alzheimer’s Disease: A Bidirectional, Stage-Dependent Account

Alzheimer’s disease (AD) has traditionally been framed as a neuronal disorder, yet white matter and myelin abnormalities are consistently detected in the preclinical period, before overt amyloid pathology or cognitive decline. This temporal relationship suggests that oligodendroc...

Alterations in Gut Microbiota and Serum Metabolome Are Associated with Postpartum Depression

Background: Postpartum depression (PPD) is a prevalent and debilitating disorder, with increasing evidence implicating the gut microbiota–brain axis. However, integrated alterations in gut microbiota and circulating metabolites in PPD remain insufficiently characterized. Methods:...

Ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry identifies 24 “unexpected” compounds to construct a one-for-one anti -counterfeiting quality markers system of Lianhua Qingwen capsule

Abstract The study completed the quantification of 110 compounds from Lianhua Qingwen ( LHQW ) capsule using library-aided ultra-high-performance liquid chromatography-quadrupole-orbitrap-tandem mass spectrometry under three adducting models ([M − H] - , [M + HCOO] - , and [M + H...