Guangzhou Medical University

An integrated bioinformatics analysis reveals that targeted activation of IL7R may reduce influenza A virus infection risk in patients with depression

Depression has been associated with increased susceptibility to influenza; however, the underlying mechanisms remain unclear. Mendelian randomization (MR) analysis was performed to assess the causal relationship between depression and influenza. Differential expression genes (DEG...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

Pseudocapacitive Charge‐Driven Adhesive‐Electrocoupling Hydrogels for Myocardial Infarction Repair via Interstitial Microenvironment Remodeling

ABSTRACT Myocardial infarction (MI) creates a hostile microenvironment characterized by oxidative stress, inflammation, fibrosis, and electrical conduction block, posing a multifaceted challenge for tissue repair. To address this, we developed a multifunctional hydrogel (Gel‐PDZC...

Pathogenesis of lymphangioleiomyomatosis: from TSC mutations, metabolic reprogramming, to microenvironmental interactions

Lymphangioleiomyomatosis is a rare disease primarily affecting women of reproductive age, characterized by progressive pulmonary cystic destruction and driven by TSC gene loss-induced constitutive mTORC1 activation. Current understanding of the disease extends beyond this primary...

Genomic insights into replicons and conjugative transfer systems of blaNDM-positive plasmids in the Enterobacter cloacae complex

The Enterobacter cloacae complex (ECC) represents a prominent opportunistic pathogen associated with multidrug-resistant nosocomial infections. The emergence of New Delhi metallo-β-lactamase (NDM)-producing ECC isolates presents a significant threat to public health, owing to the...

Integrative transcriptomic and functional profiling reveals neutrophil-associated immune dysregulation in bronchopulmonary dysplasia

Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants. Although inflammation is broadly recognized as a key contributor to BPD, the precise roles and underlying mechanisms of immune cells in BPD pathogenesis remain incompletely understood. Mo...

A non-invasive simplified scoring system to predict airway mucus plugs in asthma

Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....

Early prediction of preeclampsia among the advanced-age pregnant women: A retrospective multicenter study

Background Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity. Women of advanced maternal age (AMA, ≥ 35 years) constitute a rapidly expanding high-risk subpopulation in China. Existing first-trimester prediction models were derived in general obstetric...

Dual-step burr hole with periosteal anchoring technique: a robust method for ventricular catheter fixation – how I do it

Proximal catheter-related complications of ventriculoperitoneal shunt (VPS) and Ommaya reservoir implantation remain an important factor leading to reoperation rates and morbidity. Conventional fixation methods often fail to provide adequate mechanical stability. A shallow outer...

The VASN-YAP-MYL9 axis drives M2-like macrophage polarization and immune evasion in colorectal cancer

Tumor-associated macrophages (TAMs) polarized toward an M2-like phenotype are critical drivers of immunosuppression in colorectal cancer (CRC). While Vasorin (VASN) is implicated in poor prognosis, its specific role in orchestrating the tumor immune microenvironment remains elusi...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...

Sex-dimorphic phenotypic divergence in metabolically driven thyroid nodules: the interplay of systemic inflammation and adiposity

Metabolic dysfunction has been increasingly implicated in thyroid nodule development; however, the sex-specific interplay between systemic glucolipotoxicity, adiposity, inflammation, and thyroid nodule risk remains poorly understood. This study aimed to evaluate the association b...

Insomnia severity predicts suicide attempts in youth with depression in China: a 6-month prospective cohort study

Evidence linking insomnia to suicidal risk in depressed youth is largely cross-sectional, limiting inference about temporal direction. We examined whether baseline insomnia severity predicts subsequent suicide attempts in this population. We conducted a 6-month prospective cohort...

Multi-level static and dynamic graph-theoretical analyses of resting-state functional networks in a Chinese cohort of preterm neonates

Preterm birth influences early functional brain maturation at term-equivalent age. Using resting-state functional magnetic resonance imaging from a large Chinese neonatal cohort (62 term-born and 107 preterm neonates), we examined static and dynamic network organization using mul...

Tumor-targeted nanobubbles delivering PFP/siFGFR1 for US imaging and overcoming enzalutamide-resistant in prostate cancer

Enzalutamide (ENZ) resistance has emerged as a critical therapeutic hurdle in advanced prostate cancer (PCa) management. This study aims to investigate the potential of ultrasound-guided nanobubble-mediated co-delivery of small interfering RNA targeting fibroblast growth factor r...