Guangzhou Medical University

Study on the impact of meditation intervention on the white matter structure in schizophrenia

Schizophrenia is associated with abnormal white matter structural connectivity, and meditation has been investigated as an adjunctive intervention for clinical symptoms. This study examined whether an 8-month meditation intervention was associated with longitudinal changes in cli...

Mechanochemical Encapsulation of Enzymes in a Highly Hydrophilic HOF: Harnessing Pore Microenvironment for Enhanced Biocatalysis

ABSTRACT Enzymes immobilized within hydrogen‐bonded organic frameworks (HOFs) often suffer from reduced catalytic activity due to mass transfer limitations and pore channel blocking by residual organic solvents from conventional solution‐phase synthesis. In addition, the correlat...

Association between Airway Mucus Plugs on Computed Tomography and Respiratory Outcomes in Participants with COPD and with Preserved Spirometry: Findings from a Chinese Population

Abstract Rationale Airway mucus plugs are a prognostic marker in moderate-to-very severe chronic obstructive pulmonary disease (COPD), but their association with respiratory outcomes has been insufficiently evaluated among participants with preserved spirometry and asymptomatic C...

Single-cell analysis reveals immunotherapy-induced epithelial state remodeling and identifies PLAUR as a prognostic biomarker in colorectal cancer

Immune checkpoint blockade has achieved durable responses in a subset of colorectal cancer (CRC) patients; however, the majority derive limited benefit. While previous studies have largely focused on immune cell dynamics, how tumor epithelial cells adapt to immune selection press...

Phase 1 Dose-Escalation Study of the Rapid-Clearance Radioligand [ 177 Lu]Lu-P17-087 in Metastatic Castration-Resistant Prostate Cancer: Dosimetry, Safety, and Preliminary Efficacy

Given the rapid systemic clearance and favorable kinetic profile of the novel DOTA(GA)2-conjugated ligand [177Lu]Lu-P17-087, this phase 1 study aimed to systematically evaluate the safety, pharmacokinetics, dosimetry, and preliminary antitumor activity of escalating therapeutic a...

Perioperative prediction of ideal postoperative recovery after kidney transplantation: a multicenter retrospective cohort study

Kidney transplantation is the preferred treatment for end-stage renal disease, but early postoperative outcomes remain heterogeneous. Textbook outcome (TO), a composite measure of an ideal postoperative recovery trajectory, has emerged as a meaningful indicator of surgical qualit...

Causal inference maps the sex-dimorphic genetic architecture and inflammatory-metabolic networks underpinning perceived aging in UK Biobank

Self-perceived facial aging is an externally observable aging-related phenotype that may reflect both biological and psychosocial dimensions of aging. However, its genetic and molecular determinants, sex-specific heterogeneity, and relationship with systemic aging-related pathway...

Defective PDZK1 palmitoylation impairs epididymosome-mediated cholesterol transport and contributes to asthenozoospermia

Asthenozoospermia, a leading cause of male infertility characterized by impaired sperm motility, involves dysregulated cholesterol efflux during epididymal maturation, yet the underlying mechanisms remain elusive. Here, we demonstrate that PDZK1 protein level and its palmitoylati...

Tetrandrine-loaded manganese-doped ceria nanozyme for nebulized inhalation therapy of the ROS-driven inflammatory-fibrotic continuum

Pulmonary fibrosis (PF) and acute lung injury (ALI) represent mechanistically interrelated stages along a shared inflammatory-fibrotic disease continuum, both driven by dysregulated macrophage responses and reactive oxygen species (ROS)-mediated signaling. Effective intervention...

Retinoic acid maintains the primordial follicle reserve by inhibiting PI3K/Akt signaling

In female mammals, nonrenewable primordial follicles are orderly activated to maintain reproductive lifespan. However, the initiating regulator(s) of primordial follicle maintenance and activation remain poorly characterized. RA synthesis enzymes were mainly expressed in the pre-...

Osteoclastogenesis with FN1-associated cell differentiation, immune communication, and ECM remodeling in male SAMP6 mice

Early diagnosis and precise treatment of senile osteoporosis remain challenging. Herein, we apply a multi-omics strategy, integrating scRNA-seq and proteomics in the male 5-month-old senescence-accelerated mouse prone 6 (SAMP6) spontaneous aging model, to study early bone loss. T...

A biomimetic multienzyme‑mimetic Prussian blue nanozyme for catalytic ROS neutralization and macrophage reprogramming in photoacoustic imaging‑guided immunotherapy of acute lung injury

Acute lung injury (ALI) is a life‑threatening respiratory disease that lacks precise diagnostic tools and specific therapeutic interventions, highlighting an urgent need for theranostic strategies. Here, we developed a biomimetic multienzyme‑mimetic Prussian blue nanozyme (MM@HMP...

Tolerogenic dendritic cells modulate macrophage inflammatory response in Ulcerative colitis: role of IL-1RN

Abstract Background Ulcerative colitis (UC) is a chronic, idiopathic inflammatory disease whose pathogenesis involves various immune cells. Measures that suppress the inflammatory responses of intestinal macrophages are considered crucial for improving ulcerative colitis. In rece...

Structural and diffusion MRI markers of the choroid plexus and perivascular regions are associated with Alzheimer’s disease pathology and cognition

Abstract Background Choroid plexus (ChP) morphology and periventricular diffusion alterations have been implicated in Alzheimer’s disease (AD). However, whether ChP volume and the diffusion tensor imaging analysis along the perivascular space (DTI-ALPS) index provide complementar...

Ratio-preserved, spirometry-defined small airway dysfunction is associated with COPD: evidence from CT quantification and pathological assessments

This study investigated the radiologic and pathologic features of spirometry-defined small airway dysfunction (SAD) in patients with a preserved forced expiratory volume in one second to forced vital capacity ratio (FEV 1 /FVC > 0.7), providing evidence that SAD may be associated...

Non-apnea electrical impedance tomography for bedside ventilation–perfusion assessment during spontaneous breathing: a prospective cross-over validation study

Conventional saline-contrast electrical impedance tomography (EIT) perfusion imaging typically requires a brief end-expiratory apnea during saline injection to reduce respiratory interference. However, this maneuver is often difficult or impractical in spontaneously breathing pat...

Incidence, prevalence and outcomes of neonatal sepsis: a population-based cohort study of hospitalized neonates in Huai’an, China

Background This study aims to estimate the incidence, prevalence of morbidity and mortality rate (MR), associated risks, and the applicability of neonatal sequential organ failure assessment (nSOFA), of neonatal sepsis from a database of all hospitalized infants in a representati...

Interleukin-15-armed trivalent mRNA vaccine elicits robust and durable protection against lethal mpox and vaccinia virus challenges in mice

The global re-emergence of mpox virus (MPXV) poses a critical threat, particularly to vulnerable immunocompromised populations, thus highlighting an urgent need for effective and safe interventions. In this study, we developed and compared three mRNA-LNP candidates: a trivalent c...

The dual role of fibrinogen in vascular permeability and alveolar senescence reveals its potential as a pharmacological target for asthma

Fibrinogen (Fg), a critical mediator in vascular and inflammatory diseases, is poorly understood in asthma pathogenesis. Here, our data support a model in which Fg acts as a dual-function driver of asthma progression through distinct endothelial and epithelial mechanisms, and we...

Modulation of CD73 by Betulinic acid antagonizes nucleotide metabolic dysregulation in silica nanoparticle-induced pulmonary fibrosis

Silica nanoparticles (SiNPs) exposure presents a growing public-health concern. The mechanisms driving SiNPs-induced pulmonary fibrosis and effective interventions remain unclear. This study investigated the contribution of CD73 to SiNPs-induced pulmonary fibrosis and evaluated t...