Guangzhou Medical University

Analgesic efficacy of 0.75% ropivacaine versus 2% lidocaine after unilateral mandibular third molar extraction: a prospective observational cohort study

This prospective observational cohort study aimed to evaluate the clinical efficacy of 0.75% ropivacaine in unilateral mandibular third molar extraction and to compare its postoperative analgesic outcomes with those of 2% lidocaine. A total of 128 patients undergoing unilateral m...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Longitudinal MRI-based Delta-Habitat model for predicting pathological complete response to neoadjuvant chemoimmunotherapy in head and neck squamous cell carcinoma

To develop and validate a machine learning model integrating habitat imaging features before and after neoadjuvant chemoimmunotherapy (NACI) to predict pathological complete response (pCR) to NACI in head and neck squamous cell carcinoma (HNSCC). A multicenter retrospective study...

Correlation between clinical communication competence and transition shock among new nurses: a cross-sectional study

New nurses face severe transition shock when entering clinical practice. Clinical communication competence is one of the essential competencies for clinical nurses and is crucial to the quality of nursing care. However, this competence is affected by various factors, and relevant...

Nickase-based suppression of self-ligation in long sticky-end adapters for next-generation sequencing library preparation

The correctness and efficiency of the adapter connection are important factors affecting the quality and yield of the libraries in next-generation sequencing (NGS). Lengthening the sticky ends of the adapters and the targets can effectively improve the efficiency of ligation, how...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

A multi-class gastric biopsy artificial intelligence model developed from whole slide histopathological images

Pathological diagnosis of biopsies remains the gold standard for gastric diseases such as gastric carcinoma (GC), but it suffers from clinical misdiagnosis and high workload. Accurately distinguishing early-stage GC (EGC) from advanced-stage GC (AGC) and preoperatively predicting...

Pseudocapacitive Charge‐Driven Adhesive‐Electrocoupling Hydrogels for Myocardial Infarction Repair via Interstitial Microenvironment Remodeling

ABSTRACT Myocardial infarction (MI) creates a hostile microenvironment characterized by oxidative stress, inflammation, fibrosis, and electrical conduction block, posing a multifaceted challenge for tissue repair. To address this, we developed a multifunctional hydrogel (Gel‐PDZC...

Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation

Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOC...

An integrated bioinformatics analysis reveals that targeted activation of IL7R may reduce influenza A virus infection risk in patients with depression

Depression has been associated with increased susceptibility to influenza; however, the underlying mechanisms remain unclear. Mendelian randomization (MR) analysis was performed to assess the causal relationship between depression and influenza. Differential expression genes (DEG...

Genetic Predisposition and Pharmacological Effects Shape the Divergent Effects of Type 2 Diabetes on Atherosclerosis

Abstract Type 2 diabetes mellitus (T2D) increases the risk of atherosclerotic diseases, including coronary artery disease (CAD), but decreases that for abdominal aortic aneurysm (AAA), forming an intriguing diabetes-atherosclerosis paradox. We investigate how genetic underpinning...

Genomic insights into replicons and conjugative transfer systems of blaNDM-positive plasmids in the Enterobacter cloacae complex

The Enterobacter cloacae complex (ECC) represents a prominent opportunistic pathogen associated with multidrug-resistant nosocomial infections. The emergence of New Delhi metallo-β-lactamase (NDM)-producing ECC isolates presents a significant threat to public health, owing to the...

Pathogenesis of lymphangioleiomyomatosis: from TSC mutations, metabolic reprogramming, to microenvironmental interactions

Lymphangioleiomyomatosis is a rare disease primarily affecting women of reproductive age, characterized by progressive pulmonary cystic destruction and driven by TSC gene loss-induced constitutive mTORC1 activation. Current understanding of the disease extends beyond this primary...

Integrative transcriptomic and functional profiling reveals neutrophil-associated immune dysregulation in bronchopulmonary dysplasia

Bronchopulmonary dysplasia (BPD) is the most common chronic lung disease in preterm infants. Although inflammation is broadly recognized as a key contributor to BPD, the precise roles and underlying mechanisms of immune cells in BPD pathogenesis remain incompletely understood. Mo...

A non-invasive simplified scoring system to predict airway mucus plugs in asthma

Abstract Background Airway mucus plugs are a core pathological feature of severe asthma and are closely associated with airflow limitation and poor prognosis. However, rapid and efficient clinical screening tools for identifying airway mucus plugs in asthma are currently lacking....

The VASN-YAP-MYL9 axis drives M2-like macrophage polarization and immune evasion in colorectal cancer

Tumor-associated macrophages (TAMs) polarized toward an M2-like phenotype are critical drivers of immunosuppression in colorectal cancer (CRC). While Vasorin (VASN) is implicated in poor prognosis, its specific role in orchestrating the tumor immune microenvironment remains elusi...

Early prediction of preeclampsia among the advanced-age pregnant women: A retrospective multicenter study

Background Preeclampsia (PE) remains a leading cause of maternal and perinatal morbidity. Women of advanced maternal age (AMA, ≥ 35 years) constitute a rapidly expanding high-risk subpopulation in China. Existing first-trimester prediction models were derived in general obstetric...

Dual-step burr hole with periosteal anchoring technique: a robust method for ventricular catheter fixation – how I do it

Proximal catheter-related complications of ventriculoperitoneal shunt (VPS) and Ommaya reservoir implantation remain an important factor leading to reoperation rates and morbidity. Conventional fixation methods often fail to provide adequate mechanical stability. A shallow outer...

A cilia-associated epithelial alteration axis nominates ERICH3 as an entry point to PI3K engagement in lung adenocarcinoma

LUAD adopts heterogeneous oncogenic signalling states, and bias toward a PI3K–AKT–mTOR–engaged state is not fully explained by canonical pathway lesions. Because membrane-proximal spatial organization can tune receptor-proximal signalling yet is difficult to quantify in human tum...

Sex-dimorphic phenotypic divergence in metabolically driven thyroid nodules: the interplay of systemic inflammation and adiposity

Metabolic dysfunction has been increasingly implicated in thyroid nodule development; however, the sex-specific interplay between systemic glucolipotoxicity, adiposity, inflammation, and thyroid nodule risk remains poorly understood. This study aimed to evaluate the association b...