Guangzhou Medical University

Cognition, attitudes, and willingness toward biobank donation among the older adults: a cross-sectional survey of 1,143 participants in China

Abstract Background Biobanks are fundamental infrastructures for medical research, and their sustainable development depends on public participation and support. Older adults are at high risk of age-related diseases, making their biospecimens particularly valuable for scientific...

Dual pH/glucose-responsive berberine-loaded bioactive glass/carboxymethyl chitosan hydrogel for promoting diabetic wound healing

Diabetic wounds are characterized by a complex pathological microenvironment involving hyperglycemia-induced oxidative stress, persistent inflammation, bacterial infection and impaired matrix remodeling. In this study, we developed BBGgel, an injectable pH- and glucose-responsive...

Engineering Nanoparticles to Navigate Biological Barriers for Deep Tumor Penetration

Deep and spatially uniform drug delivery remains a major challenge in nanomedicine for solid tumor therapy. During delivery, nanoparticles must sequentially traverse multiple biological barriers, from systemic circulation and tumor accumulation to vascular extravasation, basement...

Single-nucleus transcriptomics reveals an early-relapse-associated epithelial–myeloid–T cell niche in advanced high-grade serous ovarian cancer

Early relapse remains a major clinical challenge in advanced HGSOC, but the tumor microenvironmental features associated with relapse timing remain poorly defined. Here, we performed snRNA-seq on treatment-naive tumors from patients with advanced HGSOC, including STDFS ( n = 4) a...

Prenatal Sonographic Features of Heterozygous DLL1 Single‐Nucleotide Variants and 6q27 Deletions: A Single Referral Center Retrospective Case Series

ABSTRACT Objective To present the prenatal sonographic features and genomic spectrum of pregnancies with fetuses with a DLL1 single‐nucleotide variant (SNV) or a pure 6q27 deletion. Methods This was a retrospective study of 20 cases with a DLL1 SNV or a pure 6q27 deletion diagnos...

A novel splice-site variant in CNKSR2 causes exon 16 skipping and X-linked syndromic intellectual developmental disorder

CNKSR2 -related neurodevelopmental disorder is an X-linked condition characterized by developmental delay, severe language impairment, intellectual disability, and early-onset epilepsy. Although splice-altering variants constitute an important proportion of pathogenic CNKSR2 vari...

Methyl eugenol increases neural microcirculation to promote nerve repair by regulating endothelial cell and Schwann cell communication via Ptn/Sdc4

Neuromicrocirculatory disorders often accompany nerve injury. Improving neural microcirculation can promote the repair of injured nerves. Methyl eugenol is a major bioactive component of Asarum heterotropoides and has been reported to exert analgesic effects in chronic pain. This...

Engineered mesenchymal stem cell-derived extracellular vesicles overexpressing miR-146a alleviate neuroinflammation in Alzheimer's disease.

Alzheimer’s disease is an inflammatory neurodegenerative disease for which no effective clinical treatment currently exists. We have previously reported that mesenchymal stem cell–derived extracellular vesicles delay retinal degeneration by exerting anti-inflammatory effects thou...

De Novo Discovery of Cysteine-Targeted Reversible Covalent Cyclic Peptides with Prolonged Residence Time via Phage Display

Abstract Reversible covalent targeting of cysteine residues offers a powerful strategy for generating potent and tunable ligands, but designing electrophiles with balanced reactivity, stability, and reversible binding remains challenging. Here, we systematically optimized reversi...

Tumor specific cytokine pattern explored in renal cell carcinoma

Renal cell carcinoma (RCC) is a common urological malignancy, yet the cytokine landscape of the tumor microenvironment, especially in early-stage tumors, remains poorly defined. Using antibody arrays, 174 tumor-related cytokines were measured in 20 sets of normal, para-cancerous,...

Review Article: Cancer Surveillance for Early Detection of Liver Cancer in Patients with HBV Infection

BACKGROUND AND AIMS: Chronic hepatitis B virus (HBV) infection remains a major cause of hepatocellular carcinoma (HCC). Although antiviral therapy reduces cirrhosis and liver failure, HCC may still develop in patients with HBV, including in non-cirrhotic livers. This review aimed...

Illness Experiences and Supportive Care Needs of Patients With Early‐Onset Colorectal Cancer: A Qualitative Systematic Review

AIMS: To synthesise the holistic illness experiences and supportive care needs of patients with early-onset colorectal cancer across the entire disease trajectory. BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed in indivi...

Haploidentical hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for severe aplastic anemia patients aged 40–65: a multicenter retrospective study

Abstract Immunosuppressive therapy (IST) plus eltrombopag (EPAG) (IST+EPAG) is the preferred first-line treatment for severe aplastic anemia (SAA) patients over 40 years. However, direct comparison between IST+EPAG and upfront haploidentical hematopoietic stem cell transplantatio...

Rigid-Flexible Coupling Pore Engineering in Covalent Organic Frameworks Enables the Selective Identification of Nucleotide Analogues

Abstract Covalent organic frameworks (COFs) offer programmable pore architectures and tunable host–guest interactions, yet their rigid channels limit the selective recognition of structurally similar biomolecules─a longstanding challenge in sensor design. Inspired by enzymatic po...

Selective Denitrificative Fluorination and Desulfurative Fluorination Controlled by AgF/AgF2

Abstract The development of novel N-fluoroalkylated phosphoramidates will enrich the toolbox of organophosphorus chemistry. Here, we report the synthesis of [19F]/[18F] phosphoramidofluoridates and N-CF3 phosphoramidates via two controllable fluorinations of phenyl phosphorylcarb...

Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity

Abstract Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to contribute to migraine...

Light‐Synergistic Enhanced Synaptic Devices Toward Superadditive In‐Sensor Computing

ABSTRACT Conventional neuromorphic devices face challenges in achieving efficient integration of light sensing and synaptic computation because of structural and material limitations. In this work, we developed an indium‐tin‐zinc oxide/transparent gelatin electrolyte synaptic tra...

A Molecularly Defined Midbrain Circuit Mechanism for Sound‐Driven Defensive Behavior and Anxiety

ABSTRACT The innate defense behaviors in response to threatening sounds play a fundamental role in survival. However, the neural circuits that detect threat‐relevant auditory cues and transform them into defensive behaviors remain poorly defined. Here, we identified Cerebellin‐2‐...

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

ABSTRACT Achieving on‐demand glucose control to prevent postprandial spikes remains a significant challenge in diabetes management. Here, we present a programmable self‐heating microneedle (PSH‐MN) patch for on‐demand, timed‑sequence insulin delivery. The patch features a three‐d...

Dual Compartmentalization of GSTA4 Suppresses Ferroptosis to Drive Antiandrogen Resistance in Prostate Cancer

ABSTRACT Resistance to second‐generation antiandrogens poses a major therapeutic challenge in castration‐resistant prostate cancer (CRPC). While ferroptosis evasion has been implicated in treatment failure, the key molecular determinants driving this evasive process are poorly un...