Guangzhou Medical University

Non-Destructive Chemoselective Labeling and Bioorthogonal Enrichment of Pseudouridine-Containing RNA via Facile N 1-Selective Functionalization

Abstract Pseudouridine (Ψ), often referred to as the “fifth nucleotide”, constitutes the most abundant post-transcriptional RNA modification and plays pivotal roles in regulating RNA structure and function. However, the precise mapping and functional investigation of Ψ remain cha...

Epigenetic training licenses naïve CD8 + T cell metabolic fitness and function

Naïve T cells maintain quiescence yet must respond rapidly to antigens, but how they prime this capacity is unclear. We identify histone variant H2A.Z as a key regulator of an epigenetic training program that licenses quiescent naïve CD8 + T cells for future activation. H2A.Z def...

Clinical features of oxcarbazepine-associated cutaneous reactions in patients with bipolar disorder: a retrospective case series

Oxcarbazepine (OXC) is a second-generation antiepileptic drug that has been used in selected clinical settings as an alternative or adjunctive treatment option for bipolar disorder (BD). However, reports describing OXC-associated cutaneous reactions in patients with BD remain lim...

Self-efficacy of psychiatric nurses and its influencing factors in Guangdong China

Self-efficacy is a critical factor influencing quality of care, particularly for psychiatric nurses at higher occupational risk; however, research on its current status and influencing factors among the nursing population in China remains scarce. This study aimed to investigate t...

Predicting dengue incidence in China using SARIMA and hybrid neural network models: insights for public health planning

Abstract Dengue fever remains a persistent public health challenge in tropical and subtropical regions of China, disproportionately affecting economically disadvantaged and resource-limited areas. Outbreaks of dengue can strain healthcare systems and hinder socio-economic develop...

Cross-Cohort Integration of Blood DNA Methylation and Sepsis Transcriptomes Prioritizes TP53INP1 as a Candidate Associated with B-Cell Transcriptomic Patterns in Pediatric HAdV-7-Associated Sepsis

Human adenovirus type 7 (HAdV-7) can cause severe pneumonia and sepsis in children, but the associated host epigenetic and immune alterations remain poorly defined. We profiled peripheral-blood DNA methylation in 11 children with HAdV-7-associated sepsis (6 survivors and 5 non-su...

Common SAEs and their impact on the prognosis of children treated with the CCCG-ALL-2015 protocol: a retrospective multicentre Chinese study

This study was intended to evaluate common serious adverse events (SAEs) and analyze their effects on the prognosis of acute lymphoblastic leukemia (ALL) children. We retrospectively collected the data of 7640 consecutive ALL children with/ without SAEs who were enrolled in CCCG-...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

The relationship between psychological contracts and university teachers’ work engagement: the moderating role of demands-abilities fit

Abstract Background The work engagement (WE) degree of university teachers is a key factor influencing the quality of higher education. This study explores the relationship between university teachers’ psychological contract (PC) and WE, as well as the moderating role of demands-...

Ring Expansion of Benzothiaselenazole-1-oxides via Five-Membered Selenonium Ion-Mediated Alkene Insertion into Se–N Bonds

Abstract Ring expansion of heterocyclic frameworks provides an efficient approach to structurally diverse bioactive molecules, yet such transformations of organoselenium heterocycles remain largely unexplored. Herein, we report a calcium-catalyzed insertion of alkenes into the Se...

Umpolung at the meta ‐Positions of Oxazino‐Pyridines Enabling Nucleophilic Pyridine Functionalization

Selective C─H functionalization of azines is of paramount importance to synthetic and medicinal chemistry. However, nucleophilic functionalization at meta-position of pyridines has remained elusive because of the intrinsic polarity mismatch. In this study, we report a mild and pr...

Safety and efficacy of the automated liquid-phase embryo storage, Hatchferti: a pilot study

To date, no fully automated liquid-phase embryo tank has been implemented in assisted reproductive technology (ART) laboratory and its impact on the safety and efficacy of embryo storage remains unknown. To evaluate its performance, the Hatchferti group (HG) stored a total of 230...

Effect of Intracameral Air Injection on Corneal Endothelial Cell Loss After Phacoemulsification for Cataracts of LOCS III Nuclear Grade 4 or Higher: A Randomised Clinical Trial

BACKGROUND: To evaluate the effect of intracameral air injection on corneal endothelial cells in patients undergoing phacoemulsification for cataracts with LOCS III nuclear grade 4 or higher. METHODS: A prospective randomised clinical trial. Patients with cataracts of LOCS III nu...

Umpolung at the meta ‐Positions of Oxazino‐Pyridines Enabling Nucleophilic Pyridine Functionalization

ABSTRACT Selective C─H functionalization of azines is of paramount importance to synthetic and medicinal chemistry. However, nucleophilic functionalization at meta‐ position of pyridines has remained elusive because of the intrinsic polarity mismatch. In this study, we report a m...

Saquinavir inhibits pyroptosis by regulating NLRP3 degradation to alleviate acute lung injury

Background In critically ill patients, sepsis can precipitate acute lung injury (ALI), a syndrome with high incidence in intensive care settings. Pyroptosis plays an important role in ALI, highlighting its potential as a drug target. The NLRP3-mediated classical pyroptosis pathwa...

Efficacy and safety of Shenfu injection on sepsis-induced myocardial dysfunction: a meta-analysis and trial sequential analysis

The efficacy and safety of Shenfu Injection (SFI) as an adjunctive treatment for sepsis-induced myocardial dysfunction (SIMD) remain uncertain despite preliminary investigations. Eight databases were searched for qualified randomized controlled trials (RCTs) from inception to 10...

PTK6 inhibition by tilfrinib hinders the proliferation and migration of ovarian cancer cells

Protein Tyrosine Kinase 6 (PTK6) has been implicated in the progression of multiple malignancies; however, its oncogenic role and therapeutic potential in ovarian cancer (OC) remain incompletely defined. This study systematically investigates the biological function and therapeut...

Disordered eating attitudes in hospitalized schizophrenia patients of Guangdong, China: prevalence, associated factors, and the exploratory mediating role of insight in the depression-eating attitude link

This study aimed to examine disordered eating attitudes and their associated factors among hospitalized patients with schizophrenia. The primary objective was to identify sociodemographic, clinical, and psychological factors associated with eating attitudes. The secondary objecti...

A Biomimetic cascade nanoreactor enabled by tumor microenvironment remodeling for precise CO release and enhanced cu-mediated chemodynamic therapy

Prostate cancer (PCa) is the most prevalent malignant tumor in the male genitourinary system. Carbon monoxide (CO) gas therapy and chemodynamic therapy (CDT) have emerged as alternative treatments for cancer. However, the therapeutic efficacy of both approaches is constrained by...

Pan-cancer screening and integrative multi-omics and deep learning reveal the prognostic significance of an IBD-CRC shared host–microbe signature in bladder urothelial carcinoma

Background The prognostic relevance of inflammatory bowel disease (IBD)–colorectal cancer (CRC) shared host–microbe signatures in non-intestinal epithelial malignancies remains unclear. This study aimed to evaluate the prognostic and biological significance of an IBD-CRC shared h...