Guangzhou Medical University

Admission-time prediction of 7-day mortality in clinician-attributed hypertensive intracerebral hemorrhage: development and external validation against the ICH score

Early mortality after intracerebral haemorrhage remains difficult to estimate at admission. We developed models for recorded mortality within 7 days after admission in two retrospective cohorts of clinician-attributed hypertensive intracerebral haemorrhage. Qingyuan records ( n =...

Nebulized lidocaine for preventing postoperative pulmonary complications in major abdominal surgery

Despite the lung-protective ventilation strategy, high incidence of postoperative pulmonary complications (PPCs) after major non-cardiac surgery remains a major concern in the perioperative care due to high morbidity and mortality. The study aimed to evaluate the efficacy and saf...

scGEN: Leveraging an Adaptive Weighting Strategy for Challenging Cell Clustering in Single‐Cell RNA‐seq

ABSTRACT Recent advancements in single‐cell RNA sequencing (scRNA‐seq) have greatly enhanced our ability to dissect cellular heterogeneity. However, unsupervised clustering often struggles to identify transitional or developmental boundary cells, as existing methods rely on highl...

Comparison and clinical validation of different centiloid processing methods in amyloid beta PET

The Centiloid (CL) scale has become a crucial quantitative metric for β-amyloid (Aβ) PET in Alzheimer's disease. However, variability in processing methods complicates its clinical adoption. This study systematically evaluated the reliability and clinical utility of different CL...

Development and application of a smartphone-based thermal contrast amplification reader for photothermal lateral flow immunoassays

The high cost and poor portability of external infrared thermal imagers have limited the widespread adoption of photothermal lateral flow immunoassays (PT-LFIAs) in on-site testing. To address this, we developed a smartphone-based handheld Thermal Contrast Amplification (TCA) Rea...

Shear Wave Elastography of the Tibial Nerve and Lower Limb Nerve‐Muscle‐Tendon Complex in Diabetic Peripheral Neuropathy

Objectives To investigate the associations among diabetic peripheral neuropathy (DPN), diabetic tendinopathy, and diabetic myopathy and their respective influencing factors using shear wave elastography (SWE). Methods This study enrolled 65 diabetic patients (22 with DPN [PN‐DM g...

Extracellular matrix–targeted TNC-scFv armoring enhances CAR T cell persistence and antitumor activity in solid tumors

Chimeric antigen receptor T cell (CAR T cell) therapy has shown limited efficacy in solid tumors, largely due to physical and immunosuppressive barriers imposed by the tumor microenvironment (TME). Tenascin-C (TNC), an extracellular matrix protein highly expressed in multiple sol...

circTNS3 accelerates bladder outlet obstruction-induced bladder remodeling by amplifying cGAS-STING signaling via the miR-510-5p/cGAS axis

Abstract Background Bladder outlet obstruction (BOO) induces progressive bladder remodeling through sustained intravesical pressure overload, leading to structural and functional impairment. Circular RNAs (circRNAs) play critical regulatory roles in diverse physiological and path...

Integrative bioinformatics analysis of Lianmei granules in diabetic nephropathy

Diabetic nephropathy (DN) is a severe complication of diabetes mellitus, leading to end-stage renal disease and significant morbidity. Current therapies are limited by efficacy and side effects, highlighting the need for novel treatments. Lianmei granules (LMG) show potential for...

Family history and education moderate adherence and knowledge in viral hepatitis patients: a cross-sectional study in Guangzhou, China

Abstract Background Hepatocellular carcinoma and cirrhosis due to viral hepatitis is a severe menace to global community health and is financially and medically significant. Despite the low level of adherence to follow-up, standardized follow-up at the long term is essential to p...

ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice

Abstract Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly...

Effects of Maternal Caffeine Exposure During Gestation on Neurobehavior, Glucose Metabolism and Circadian Rhythm in Offspring Rats

Caffeine intake can have numerous effects on neurological and cognitive impairments. However, its influences on offspring still need to be evaluated. This study aimed to investigate the effects of caffeine exposure during gestation on behavioral development, metabolic function, a...

Genetic Investigation of Pregnancies With an Isolated Fetal Pelvic Kidney

ABSTRACT Objective To explore genetic investigative results in fetuses with isolated pelvic kidney. Methods This was a retrospective study of 212 fetuses with isolated pelvic kidney diagnosed on second trimester anatomy ultrasound. All cases underwent invasive prenatal diagnosis...

Esketamine’s therapeutic effect on anhedonia in adolescents: a post-hoc of a randomized controlled trial

Abstract Background Anhedonia, a prominent symptom of major depressive disorder (MDD), severely impairs patients’ quality of life and is challenging to treat. Although esketamine has shown potential in treating anhedonia in adult treatment-resistant MDD, its effects on adolescent...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Bioinspired Hierarchical Silica Nanoarchitecture for VOCs Discrimination through Confined-Space Optical Modulation

Abstract Optical discrimination of volatile organic compounds (VOCs) commonly relies on chemically active materials or multisensor arrays, making stable signal transduction and structural integration challenging. Here, we report a bioinspired hierarchical silica nanoarchitecture...

Comparison of sevoflurane and propofol on the novel oxygenation index and respiratory mechanics in gynecological laparoscopic surgery: a randomized controlled trial

The novel oxygenation index (NOI), which incorporates mean airway pressure (Pmean) as a key respiratory parameter, is increasingly being investigated for its enhanced ability to reflect patients’ pulmonary function compared to the traditional oxygenation index (OI). This study ai...

Ultrasensitive Electrochemiluminescence Aptasensor With DNA Nanotetrahedron Amplification for Multilevel Detection of cTnI From Cells to Patients

ABSTRACT Accurate detection of myocardial injury (MI) biomarkers for assessing anticancer drug‐induced cardiotoxicity has long been constrained by insufficient capture efficiency and limited assay sensitivity. To address this challenge, we developed an electrochemiluminescence (E...

Ligustrazine Alleviates Nitroglycerin‐Induced Migraine by Regulating Mitochondrial Energy Metabolism Through the Concurrent Regulation of CypD, ANT, and PAR2

ABSTRACT To investigate the protective effects of ligustrazine (Lig) against nitroglycerin (NTG)‐induced migraine and explore its underlying mechanisms, with a particular focus on mitochondrial energy metabolism and the coordinated regulation of protease‐activated receptor 2 (PAR...

Interpretable CT-Based Radiomics for Prediction of High-Affinity Neoantigens Associated Immunogenic States in Advanced Hepatocellular Carcinoma Treated with TACE Plus Targeted Therapy and Immunotherapy

Objectives: To develop and validate a CT radiomics-based machine learning model for the noninvasive prediction of HANS status in advanced HCC and to investigate the prognostic and genomic characteristics associated with HANS status. Materials and Methods: This retrospective study...