Goethe University Frankfurt

Supporting climate change adaptation worldwide: a web application for exploring uncertain future changes in water resources

Abstract. While adaptation to changing water resources due to climate change is necessary everywhere, information about their potential future changes has not been easily accessible to most climate change adaptation processes. The free interactive web application Climate Change I...

Schizophrenia research in 2026: report from the annual meeting of the Schizophrenia International Research Society

Abstract SIRS 2026, held under the theme “Schizophrenia Research in the Era of Artificial Intelligence,” brought together researchers, clinicians, and persons with lived experience to take stock of a field whose tools for measuring, predicting, and intervening in psychosis have e...

Decoupling T cell cytotoxicity: a CCL21+ICAM1-based synthetic immune niche enhances tumor elimination by accelerating lytic hit delivery

Preserving T cell cytotoxic function during ex vivo expansion remains a major challenge for adoptive cancer immunotherapy. A synthetic immune niche (SIN) composed of immobilized CCL21 and ICAM1 was shown to improve T cell expansion while preserving cytotoxicity; however, it remai...

Impact of Oxygen Vibrations on Raman Intensity Variation in the Catalyst Fe2(MoO4)3

Abstract Iron molybdate (Fe2(MoO4)3) is a widely used commercial catalyst for oxidative dehydrogenation. Recently, the possibility that bulk oxygen atoms participate in catalytic reactions has been proposed based on the experimentally observed significant reduction in Raman inten...

Intraoperative OCT-Based Stromal Topography in Phototherapeutic Keratectomy

Objectives: This study aims to investigate whether anterior corneal curvature can be reliably measured by combined Placido–optical coherence tomography (OCT) during phototherapeutic keratectomy (PTK) despite intraoperative stromal swelling, and to quantify the immediate smoothing...

German Vowel Contrast Discrimination by Turkish–German Bilingual Preschool Children: Effects of Age, Language Status, and Type of Bilingualism

Although bilingual vowel perception has received great interest in the past, surprisingly few studies have focused on preschool children. To shed light on this understudied age group, the present study investigated 5- to 7-year-old Turkish–German bilingual children ( n = 24), age...

Current Discussion on Research Data and Research Software in Germany

A presentation on current topics in the field of research data and research software from a German perspective. The lecture was delivered by invitation on 13th October 2026, at Ilia State University in Tbilisi.

Omega-3 supplementation during pregnancy in relation to reported information sources: an exploratory cross-sectional study

Abstract Background Omega-3 fatty acid supplementation during pregnancy is recommended in certain settings and may be relevant for maternal and fetal health, yet uptake varies widely. While educational attainment is commonly considered a determinant of health behavior, the relati...

PI3Kδ is selectively inhibited by roginolisib by stabilizing the C-terminal helix kα12

Abstract Phosphoinositide 3-kinases (PI3Ks) are major regulators of cell growth, proliferation and signalling, constituting key therapeutic targets in cancer, inflammation, and other diseases. Individual class I PI3K isoforms control key cellular functions, imposing the need to g...

Mesoscale structures in signed networks

Mesoscale structures in signed networks have been studied under the limiting assumption of the validity of social balance theory, which predicts positive connections within groups and negative connections between groups. Here, we propose and apply a methodology that overcomes thi...

An Orthogonal Quantitative NMR-FRET Approach for Integrity-Resolved Analysis of Lipid Vesicle Dynamics

Abstract While lipid-based vesicles gain increasing attention as biomembrane models, artificial cells, and drug carriers, analytical investigation of their composition and integrity remains a major challenge, particularly for monitoring changes during processing and membrane tran...

The relationship between EU fiscal transfers and the European policy profile of political parties

This research note examines how fiscal transfers within the European Union shape the programmatic strategies of domestic political parties. We argue that a country’s net-contributor or net-receiving status conditions the strategies how parties articulate their positions on Europe...

Carbonic Acid (H2CO3) Decomposes to Its Monohydrate (H2CO3·H2O) and CO2 on Decompression

Abstract The presence of H2O and CO2 on the icy moons in our solar system and in potentially habitable water worlds makes the understanding of phase stabilities and structure–property relations of phases in the H2O–CO2 system highly relevant for astrophysical research. Here we sh...

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

The AMIGa complex is at the crossroads of cytochrome c oxidase and ATP synthase biogenesis

Abstract Cytochrome c oxidase (CIV) and ATP synthase are part of the oxidative phosphorylation machinery. Their modular, highly regulated assembly requires specific factors and is coordinated through a common intermediate, the Atco complex, composed of the Atp9 ring and Cox6. By...

DHODH is the key target of the KDM4 inhibitor QC6352 in glioblastoma stem cells

Abstract Histone lysine demethylase 4 (KDM4) enzymes are frequently overexpressed in cancer and are considered to be promising therapeutic targets. QC6352, which is widely used as a best-in-class KDM4 chemical probe, shows potent antitumor activity across cancer models. Using com...

Consistent estimates of carbonyl sulfide and methane stratospheric lifetimes retrieved from AirCore profiles at different latitudes

Stratospheric loss is a major sink for both carbonyl sulfide (COS) and methane (CH 4 ), but their stratospheric lifetimes and sinks remain poorly constrained because high-resolution observations of their vertical distributions in the lower stratosphere are sparse. Here, we estima...

Interdependence of dental parameters, mandibular mobility and static postural sway as well as load distribution in male subjects of advanced working age

Abstract Background Maintaining static postural sway as well as load distribution is an essential component of overall physical stability in older age. The temporomandibular system is a measurable influencing factor due to functional interdependencies, although it has not yet bee...

Healthcare Utilization and Direct Medical Costs of Hepatocellular Carcinoma Treatment — A German Claims Data Study of 2778 Patients

Hepatocellular carcinoma (HCC) is a cancer with rising incidence and economic burden. However, evidence on healthcare resource utilization (HCRU) and associated costs is scarce in Europe. This study aims to determine HCRU and costs of HCC from a German third-party payer's perspec...

Bayesian Learning of Distance Metrics Beyond RMSD for Biomolecule Alignment, Clustering, and Domain Identification

Abstract Root-mean-square deviation (RMSD) is the standard metric of structural comparison in molecular dynamics (MD) simulations. In its conventional form, RMSD assigns equal weight to all atoms regardless of mobility. Hence, flexible loops and disordered regions can dominate a...