Goethe University Frankfurt

An additional water is introduced into the manganese cluster during the formation of the S3 state of photosystem II

During photosynthetic water oxidation, the Mn4Ca cluster in Photosystem II progresses through five intermediate Si (i = 0–4) states. X-ray crystallography studies have reported the insertion of one new O ligand during the formation of the S3 state, but recent studies question the...

Efficacy and safety of fenfluramine in Dravet syndrome: The impact of patient clinical characteristics

Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...

Correlation of polygenic risk score and clinical phenotype in patients with genetic generalized epilepsy

Abstract Objective The polygenic risk score (PRS) for individuals with genetic generalized epilepsy (GGE) quantifies the common risk variants in genes identified in genome‐wide association studies. We hypothesized that the phenotype of GGE patients differs based on their GGE PRS....

Clinical characteristics, treatment patterns, and survival outcomes in ductal prostate cancer: a multicenter retrospective analysis

Abstract Purpose Prostatic ductal adenocarcinoma (PDA) is a rare, aggressive prostate cancer subtype associated with advanced disease and poorer prognosis than acinar adenocarcinoma. Small ductal components influence management and preclude active surveillance. This study analyze...

Fast-Forward: Automatic Assignment and Assessment of Bonded Parameters for the Martini Force Field

Abstract Coarse-grained molecular dynamics simulations of bio- and macromolecular systems offer a method of accessing otherwise unobtainable time and length scales, compared to atomistic simulation techniques. However, a limiting step is often the generation and validation of the...

Macrocyclization of Broad-Spectrum Kinase Inhibitor Bosutinib Leads to Potent and Selective Quinoline-Based HIPK4 Inhibitor AZ137

ABSTRACT Homeodomain-interacting protein kinase 4 (HIPK4) remains an understudied member of the dark kinome. While genetic knockout studies suggest roles for HIPK4 in spermiogenesis and cutaneous squamous cell carcinoma, whether these cellular functions can be recapitulated by ph...

European S2k guidelines for hidradenitis suppurativa/acne inversa Part 1. Epidemiology, diagnosis and clinical assessment

BACKGROUND: This first part of the S2k guidelines is an update of the 2015 S1 European guidelines based on the structured assessment of clinically relevant topics by the panel of experts. It is complemented by Part 2, which deals with treatments. OBJECTIVES: These guidelines aim...

Reconstitution of glycan-driven MHC-I recycling reveals calreticulin as mediator between TAPBPR and tapasin

Abstract Protein folding in the endoplasmic reticulum (ER) is essential for about one-third of the mammalian proteome. N-linked glycosylation and subsequent glycan remodeling barcodes glycoproteins during their maturation in the ER. Major histocompatibility complex class I (MHC I...

Initial reef building in the oceanic barrier reef of Elbingerode, Mid-Devonian, Harz Mts., Germany

Abstract The Elbingerode reef complex is a Devonian reef system in the Harz Mountains and well known for its thick and fossil-rich limestones that formed an oceanic barrier reef system in the Rhenohercynian Basin. The initial reef building of this barrier reef system, exposed in...

Glimpse into the past: Analyses of the middle and inner ear of extinct rodents (Eusciurida; Rodentia; Mammalia) with implications for their locomotory behaviour

Abstract Rodentia is the most diverse and species-rich group of mammals, inhabiting almost all regions and ecosystems on earth. One of the most specialised subgroups is the Eusciurida, composed of Sciuridae, Gliridae, and Aplodontia rufa , and characterised by arboreal, fossorial...

Electroreduction of Activated Esters Catalyzed bya Manganese Complex

Abstract Electrochemical hydrogenation (electrohydrogenation) using electrons and protons as H2 surrogates offers a sustainable alternative to conventional reduction methods. Herein, we report the manganese-catalyzed electroreduction of activated esters employing a derivative of...

Language Models as a Challenge for Business Ethics – A Partially Open-Source Approach

Abstract Large language models have become central infrastructures of contemporary digital economies while raising persistent ethical concerns regarding linguistic inequality, opacity, data governance, and the concentration of technological power. Much of the current debate on AI...

A Systematic Review and Meta-Analysis on 30-Day Readmission Rates After Endovascular Abdominal Aortic Aneurysm Repair and Open Repair

AIM: Endovascular aneurysm repair (EVAR) and open aneurysm repair (OAR) are established treatments for abdominal aortic aneurysm (AAA). This meta-analysis evaluated 30-day readmission, patient characteristics, postoperative complications, and length of stay after EVAR and OAR, an...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...

Labor Market Rigidity and Employment: Firm-level Evidence

Abstract We examine the effect of labor market rigidity on firms’ employment decisions in OECD countries using a rich firm-level panel dataset covering 164,048 firm-year observations. Exploiting intertemporal variation in country-level employment protection legislation (EPL), we...

A comprehensive look at Respiratory Syncytial Virus (RSV): from pathogenesis to prevention

Respiratory Syncytial Virus (RSV) is a formidable respiratory pathogen that particularly affects infants and children. RSV presents with diverse clinical severity, most often causing mild upper airway symptoms but sometimes progressing to severe and potentially fatal lower respir...

Seismic Constraints of the 23 November 2025 Hayli Gubbi Eruption Sequence in Afar, Ethiopia

Abstract On 23 November 2025, the Hayli Gubbi volcano in Afar (Ethiopia) erupted in a massive explosion. We present the first seismic characterization using data from 13 regional seismological stations. Seismograms reveal signals consisting of a minute‐long precursor, a main erup...

“We could do more”: exploring violance prevention measures in German outpatient primary care — a qualitative study

Healthcare workers in general practice are exposed to verbal and physical violence from patients and accompanying persons. While research has predominantly focused on hospital settings, evidence on violence prevention in primary care remains limited. General practice staff often...

Environmentally induced dynamics between intraindividual variation and trait means across vegetative, phenological, and floral traits

PREMISE: Intraindividual variation in reiterated structures (e.g., leaves) represents an important dimension of phenotypic variation that contributes to functional diversity and the dynamics of ecological communities. It can be expressed differently across plant traits, but how e...

An analysis of the socially differentiated associations between digital skills and starting an apprenticeship in Germany

Earlier research documented that youth from lower SES have lower level of digital skills compared to those from high SES. However, we still lack evidence regarding the benefits of digital skills for the transition to apprenticeship for youth with different social backgrounds. We...