Ghent University

In Vitro Pharmacological Characterization of a Series of 5‐Cyano Desnitazene Opioids or “Cyanazenes”

ABSTRACT The new synthetic opioid (NSO) market has been reshaped by the emergence of an opioid class known as “nitazenes,” 2‐benzylbenzimidazole opioids spanning a wide potency range, with several analogues surpassing the potency of fentanyl. The recently identified compound 5‐cy...

A redox-regulated RCC1-like protein controls catalase activity in Arabidopsis

Abstract Reactive oxygen species (ROS) are central regulators of plant growth and stress responses. Cellular ROS levels are tightly controlled by antioxidant systems, including the evolutionarily conserved catalases that detoxify hydrogen peroxide (H 2 O 2 ) predominantly within...

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines for antimicrobial and non-steroidal anti-inflammatory drug use in bovine respiratory disease

<ns5:p> Background Bovine respiratory disease (BRD) is a major cause of morbidity, mortality, impaired welfare, production loss, and antimicrobial use in cattle. These European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines provide evidence-based...

Improving Functional Oral Intake in Head and Neck Cancer Survivors with Chronic Radiation-Associated Dysphagia – The Multicenter Randomized Controlled HIT-CRAD Trial

This randomized controlled trial evaluated the efficacy of home-based treatment programs for chronic radiation associated dysphagia (CRAD) in head and neck cancer (HNC) patients, comparing high-volume strength training to combined strength-skill training with either real or sham...

Widespread thermophilization but weak link to climate warming in Europe’s summit plant communities

Abstract Recent changes in alpine vegetation are often attributed to climate warming, particularly community composition shifts towards more warmth-associated species, or thermophilization. Here we assess the link between thermophilization and warming across 53 European mountain...

Availability and representativeness of freshwater macroinvertebrate data to enable Europe-wide assessment of biodiversity trends

Freshwater ecosystems, though covering less than 1% of Earth's surface, harbor around 10% of all species. Pressures like pollution, water extraction, and habitat loss can exhibit complex interactions in their effects on freshwater biodiversity. Understanding the effects of these...

Integrated single-cell transcriptomic, proteomic, and tissue-level analysis defines cancer-associated fibroblast programs in pseudomyxoma peritonei

Pseudomyxoma peritonei (PMP) is an ultra-rare mucinous neoplasm with extensive stromal remodeling, yet the role of cancer-associated fibroblasts (CAFs) remains poorly defined. A PMP-derived CAF culture was established and characterized through multiple omics and phenotypic assays...

Groundwater Aquifer Characterization and Potential Assessment of the Shallow Aquifers in the Volcanic Highlands of Northwestern Ethiopia

Estimating transmissivity and hydraulic conductivity is crucial for groundwater resource assessment, flow modeling, pollution remediation, and sustainability studies. In the volcanic highlands of Ethiopia, millions rely on hand-dug wells and springs for drinking and irrigation, y...

A cooperative regulatory module between TAGL2 and JMJC1 activates specific defense genes against root‐knot nematodes in tomato

Summary Plant‐parasitic nematodes (PPNs) threaten global food security. Although epigenetic modifications are crucial for plant immunity, how histone modifiers contribute to root‐knot nematodes (RKNs, Meloidogyne incognita ) resistance remains unclear. Here, using genetic, molecu...

Effects of different volumes of a water-soluble and biodegradable nesting material on behavior, pain, glycemia, farrowing traits, and performance in crated sows

Abstract This study evaluated the effects of providing 3–15 kg of a soluble and biodegradable biopolymer-based enrichment material (blend of biodegradable polymers and natural fibers) to prepartum sows housed in farrowing crates. Fifteen sows were blocked by body weight and backf...

Larval ExposureRather than Adult Worm Burden ShapesSystemic and Mucosal Th2 Immunity in Ascaris suum Infected Pigs

Abstract Ascariasis is a prevalent parasitic infection in both humans and pigs, resulting in significant human morbidity and economic losses in the porcine industry. Experimental infections are often studied by mimicking natural settings, exposing the host to frequent, small dose...

Environmentally induced dynamics between intraindividual variation and trait means across vegetative, phenological, and floral traits

PREMISE: Intraindividual variation in reiterated structures (e.g., leaves) represents an important dimension of phenotypic variation that contributes to functional diversity and the dynamics of ecological communities. It can be expressed differently across plant traits, but how e...

MechanochemicalSynthesis of [Rh(L)(acac)(CO] Complexes(L = N-Heterocyclic Carbene or Phosphine)

Abstract The mechanochemical synthesis of well-defined [Rh(L)(acac)(CO)] (L = NHC or phosphine) complexes via planetary milling and manual grinding with a mortar and pestle is reported. This solventless protocol, which proceeds via a ligand displacement from [Rh(acac)(CO)2], was...

Integrative benchmarking and automation of clonal reconstruction of somatic mutations in single-sample tumor genome analysis

Abstract Background Accurate identification of truncal mutations, those present in all tumor cells, is essential for understanding tumor evolution and guiding downstream analyses in cancer genomics, including detection of minimal residual disease. Existing clonal reconstruction t...

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Reduced Food Availability Amplifies Behavioral Depression and Impairs Locomotor Performance After Immune Challenge in Xenopus laevis

Mounting an immune response and locomotor activity are energetically costly processes that can generate trade-offs affecting energy allocation, muscle performance, and activity patterns. The balance between these demands can be modulated by factors such as food availability and e...

KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications - Supplementary Methods

Supplementary Materials and Methods for "KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications" accepted for publication in Haematologica (2026) The published article includes an abbreviated Methods sec...

KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications - Supplementary Methods

Supplementary Materials and Methods for "KSR2 is a novel oncogene in TAL1 subtype of T-cell acute lymphoblastic leukemia with potential clinical and prognostic implications" accepted for publication in Haematologica (2026) The published article includes an abbreviated Methods sec...

Derivation of a Bioavailability-Based Environmental Quality Standard for Copper in European Freshwaters under the Water Framework Directive using an updated methodology

Copper (Cu) is a river basin specific pollutant under the European Water Framework Directive (WFD). Compliance assessment under the WFD should be based on a tiered approach that considers a bioavailability correction integrating local physico-chemistry conditions. The existing pr...

Bone Accrual During Puberty Suppression and Gender-Affirming Therapy in Transgender Adolescents

Importance Puberty is a critical window for bone mass acquisition, determining lifelong fracture risk. Gonadotropin-releasing hormone agonist (GnRHa)–based pubertal suppression followed by gender-affirming hormone therapy (GAHT) is increasingly used in transgender and gender-dive...