East China Normal University

Joint effects of air pollution and compound dry-hot extremes on cardiovascular disease risk across adults: a cohort study in China

Compound dry-hot extremes (CDHEs) and ambient air pollution are growing public health threats under global climate change, yet their joint impacts on cardiovascular disease (CVD) risk remain poorly understood. We conducted a nationwide longitudinal cohort study using data from th...

Wintertime organic carbon export provides a potential food source for zooplankton in the High Arctic

Abstract Pulsed particulate organic carbon export plays a vital role in sustaining Arctic marine ecosystems and the biological pump. Wintertime particulate organic carbon export in ice-covered Arctic waters is generally considered negligible due to light-limited local primary pro...

Palladium-CatalyzedAsymmetric Remote Hydroaminationof Internal Alkenes

Abstract Asymmetric catalytic hydroamination of alkenes represents one of the most efficient strategies for constructing chiral N-heterocycles. Herein, we realize the asymmetric intramolecular remote hydroamination of internal cis-alkenes via palladium catalysis. The reaction pro...

A Highly General Potential‐Gating Strategy for Electrocatalytic Upcycling of Waste Polyester Plastics

ABSTRACT Electrocatalytic upcycling of waste polyester plastics driven by renewable electricity offers a sustainable route for resource utilization, yet its practical implementation is hampered by the poor selectivity control stemming from the inherent complex monomer of polyeste...

Endothelial Bmal1 coordinates intrinsic and paracrine mechanisms to limit post-injury vascular restenosis

Circadian rhythms have been implicated in the regulation of cardiovascular physiology and disease. Disruption of circadian signaling has been linked to exaggerated neointimal hyperplasia and delayed endothelial repair. Bmal1, a core component of the molecular clock, plays a criti...

MedKGent: a large language model agent framework for constructing temporally evolving medical knowledge graph

The rapid expansion of medical literature challenges the scalable structuring of domain knowledge. Knowledge Graphs (KGs) offer a solution, yet current construction methods lack generalizability and ignore the temporal dynamics of evolving knowledge. To address this, we introduce...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...

State-dependent reconfiguration failure of the basal forebrain-cortical gradient in Parkinson’s disease with freezing of gait

Accumulating evidence implicates cholinergic dysfunction in freezing of gait (FOG) in Parkinson’s disease (PD). Given the basal forebrain (BF) provides the primary cholinergic input to the cortex, elucidating BF-cortical connectivity and its dynamic reconfiguration during motor c...

Resource-Efficient Simulation of Molecular Groundand Excited States Based on Contextual Subspace and Quantum SubspaceExpansion

Abstract Predicting spectra and photochemical pathways relies on the computation of molecular excited states. However, the practicality of near-term variational quantum algorithms is threatened by the prohibitive growth of measurement overheads. Integrating Quantum Subspace Expan...

The Impact of Perceived Teacher Emotional Support on Student Learning: A Meta-Analysis

Teacher emotional support (TES) has been widely recognized as an important factor influencing students’ learning and development. However, empirical studies provide inconsistent evidence regarding the strength of the relationship between those two. The present meta-analysis, ther...

The Pharmacology of CAR T Cell Therapy for Autoimmune Disease

For decades, autoimmune disease treatment depended on long-term immunosuppression, which seldom yields lasting immune tolerance and carries cumulative toxic risks. Recent cell therapies, including chimeric antigen receptor (CAR) T cells, regulatory T cells, and mesenchymal stroma...

Photo‐ and Electrochemical Chlorination for (Hetero)Aryl C( sp 2 )─Cl Bond Formation

ABSTRACT Chlorinated (hetero)arenes are key structural motifs existed in various bioactive molecules, and serve as versatile building blocks in modern organic synthesis. Classical chlorination methods generally suffer from harsh reaction conditions, corrosive chlorinated reagents...

Accessibility Evaluation and Educational Implications for Ecological Civilization Education Fields: A Case Study of the Tibet Autonomous Region, China

Ecological civilization education has become an important component of environmental education and sustainable development strategies in China. Field-based learning in real ecological environments is essential for helping students understand ecological processes and human–environ...