East China Normal University

State-dependent reconfiguration failure of the basal forebrain-cortical gradient in Parkinson’s disease with freezing of gait

Accumulating evidence implicates cholinergic dysfunction in freezing of gait (FOG) in Parkinson’s disease (PD). Given the basal forebrain (BF) provides the primary cholinergic input to the cortex, elucidating BF-cortical connectivity and its dynamic reconfiguration during motor c...

MedKGent: a large language model agent framework for constructing temporally evolving medical knowledge graph

The rapid expansion of medical literature challenges the scalable structuring of domain knowledge. Knowledge Graphs (KGs) offer a solution, yet current construction methods lack generalizability and ignore the temporal dynamics of evolving knowledge. To address this, we introduce...

From intravascular imaging to adaptive vascular care: intelligent photonics and digital twins in panvascular disease

Panvascular diseases (PVDs) stand as the leading cause of global mortality, necessitating a paradigm shift from local anatomical repair to the systemic restoration of vascular homeostasis. While intravascular optical imaging has revolutionized diagnosis, it remains a passive obse...

Resource-Efficient Simulation of Molecular Groundand Excited States Based on Contextual Subspace and Quantum SubspaceExpansion

Abstract Predicting spectra and photochemical pathways relies on the computation of molecular excited states. However, the practicality of near-term variational quantum algorithms is threatened by the prohibitive growth of measurement overheads. Integrating Quantum Subspace Expan...

The Impact of Perceived Teacher Emotional Support on Student Learning: A Meta-Analysis

Teacher emotional support (TES) has been widely recognized as an important factor influencing students’ learning and development. However, empirical studies provide inconsistent evidence regarding the strength of the relationship between those two. The present meta-analysis, ther...

Photo‐ and Electrochemical Chlorination for (Hetero)Aryl C( sp 2 )─Cl Bond Formation

ABSTRACT Chlorinated (hetero)arenes are key structural motifs existed in various bioactive molecules, and serve as versatile building blocks in modern organic synthesis. Classical chlorination methods generally suffer from harsh reaction conditions, corrosive chlorinated reagents...

The Pharmacology of CAR T Cell Therapy for Autoimmune Disease

For decades, autoimmune disease treatment depended on long-term immunosuppression, which seldom yields lasting immune tolerance and carries cumulative toxic risks. Recent cell therapies, including chimeric antigen receptor (CAR) T cells, regulatory T cells, and mesenchymal stroma...

Accessibility Evaluation and Educational Implications for Ecological Civilization Education Fields: A Case Study of the Tibet Autonomous Region, China

Ecological civilization education has become an important component of environmental education and sustainable development strategies in China. Field-based learning in real ecological environments is essential for helping students understand ecological processes and human–environ...