Cornell University

Metabolomic profiling reveals distinct and shared biology in COPD and IPF

Chronic Obstructive Pulmonary disease (COPD) and Idiopathic Pulmonary Fibrosis (IPF) are chronic pulmonary disorders with distinct pathologies but shared risk factors. Metabolomics may provide insights into mechanisms. To identify metabolites associated with COPD and IPF, and to...

DUSP4 overexpression is associated with MAPK pathway alterations in low-grade serous ovarian cancer

MAPK pathway alterations, most commonly KRAS , NRAS , and BRAF mutations, occur in approximately 50–60% of ovarian low-grade serous carcinomas (LGSCs). We sought to identify clinically translatable markers of MAPK pathway activation in LGSC samples. Differential gene expression a...

A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans

The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation...

A Dual-Component Nurse Practitioner Intervention to Improve Symptom Management for Caregivers of Persons Living With Dementia

The number of patients living with dementia (PLWD) has steadily increased, making it the fifth leading cause of death among adults. While hospice care is standard for end-of-life symptom management, predicting 6-month survival is challenging, leaving many who could benefit inelig...

Can electronic quantum criticality drive phonon-induced linear-in-temperature resistivity?

Optical phonons naturally generate linear-in-temperature ( T T ) resistivity in the equipartition regime, but their finite gap prevents this mechanism from surviving to asymptotically low temperatures. Here we analyze whether proximity to an electronic quantum critical point can...

Hypoxia-activated scleraxis a mediates epicardial progenitor differentiation into a unique cardiac perivascular cell type

Abstract The epicardium is a crucial source of progenitor cells and paracrine signals that support heart development and regeneration. However, the molecular mechanisms that guide epicardial cell fate decisions remain incompletely understood. Here, we identify the transcription f...

Mental Health Counselors’ Adaptive Functioning: Exploring Burnout, Occupational Well-Being, and Psychological Resources

Mental health counselors routinely work in emotionally demanding environments that require sustained psychological and occupational functioning. Identifying psychological resources and occupational factors that support adaptive functioning may inform strategies to enhance counsel...

General C(sp3)–C(sp3)Cross-Coupling of Primary Amines via in Situ Diazene Formation

Abstract Primary amines are among the most abundant and readily available functional groups, yet their direct use as alkyl cross-coupling partners remains underdeveloped. We report a general platform for C(sp3)–C(sp3) cross-coupling enabled by the in situ formation and visible-li...

Discovery and Characterization of Inhibitors of Ubiquitin-Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Diseases

Abstract UBA5 is the E1 enzyme that initiates UFMylation, a ubiquitin-like modification implicated in proteostasis, neurodegeneration, and cancer. Here, we report a chemical biology approach to interrogate UBA5 function through small-molecule inhibition. We developed a robust hig...

A multicenter pilot study of nivolumab with drug-eluting bead transarterial chemoembolization in patients with liver-limited hepatocellular carcinoma

Background Drug-eluting bead transarterial chemoembolization (deb-TACE) is a standard for liver-limited, locally advanced hepatocellular carcinoma (HCC) and may enhance response to immune checkpoint inhibition through tumor immune microenvironment modulation. We evaluated nivolum...

Forecast-based attribution of the role of stratospheric variability in weather extremes

Abstract. Variability of the stratospheric polar vortex, particularly its dramatic breakdown during sudden stratospheric warming (SSW) events, has been linked to a number of surface weather extremes. However, attributing the role of stratospheric variability in a specific observe...

History of divergence and gene flow shaping geographic variation in Andean warblers (Myioborus).

Studying how genetic variation is structured across space, and how it relates to divergence in phenotypic traits relevant to reproductive isolation, is important for our understanding of the speciation process. We used ddRAD-seq data to examine genetic variation across the distri...

Epidural 0.125% ropivacaine is safe but insufficient for induced tibiotarsal joint pain

Abstract Background Epidural injection of a low concentration of the local anaesthetic ropivacaine produces analgesia without neurological deficits or ileus in people. Objective To determine if epidural 0.125% ropivacaine mitigates induced hindlimb lameness in horses while preser...

Organic inputs and tillage differentially impact soil health and yield in rice–wheat systems in the eastern gangetic plain

The rice (Oryza sativa L.) – wheat (Triticum aestivum L.) rotation is the dominant cropping system of the Indo-Gangetic Plain and is experiencing challenges from a variety of environmental and socio-economic factors. Organic matter cycling and zero-tillage (ZT) have been encourag...

An argument for parsimony in differentiable hydrologic models

Abstract. Differentiable hydrologic models that use machine learning to infer parameters for process-based models show promise for both prediction and inference. However, these models are often developed with time-varying parameters, despite evidence that such flexibility can und...

Rollover motor vehicle crashes and occupant ejection: comparative analysis from a Middle Eastern trauma center

OBJECTIVES: Rollover motor vehicle crashes (ROCs) and occupant ejection (OE) are associated with worse outcomes. We studied the incidence, predictors, injury patterns, and outcomes of ROCs and OE in a rapidly developing country. METHODS: This was a retrospective analysis of the Q...

High current ultrawide bandgap AlGaN pin diodes with low on-resistance and UVC emission

We report ultrawide-bandgap AlGaN pin diodes with high forward current density and deep-ultraviolet (DUV) electroluminescence signaling efficient carrier injection. The devices incorporate a 100 nm unintentionally doped intrinsic layer between polarization-doped n- and p-type reg...

Wnt Pathway Agonism as a Therapeutic Strategy for Retinal Vascular Diseases: A Narrative Review of Evidence to Date

Breakdown of the blood–retinal barrier (BRB) is implicated in many blinding retinal diseases, including diabetic macular edema, neovascular age-related macular degeneration, and retinal vein occlusion. Anti-vascular endothelial growth factor (anti-VEGF) therapies or laser photoco...

Infectious complications following bispecific antibody or CAR T therapy in adult patients with hematologic malignancies: a retrospective database analysis

T-cell redirection therapies, including bispecific antibodies (BsAbs) and chimeric antigen receptor (CAR) T therapy, have transformed the treatment of relapsed or refractory hematologic malignancies. However, comparative data on infectious complications between these treatments r...

Haplotype phasing of de novo chromosome-level assembly of ‘Antonovka’ facilitated the identification of candidate genes for apple scab resistance

Malus genomic resources with improved quality are becoming an integral part of candidate gene identification and functional validation. Recently, we released a reference-based phased chromosome-level genome assembly of ‘Antonovka’ 172670B Malus domestica cultivar from the ‘Antono...