Copenhagen University Hospital

Perioperative Use of Vasoactive Agents in Patients Undergoing Gastrointestinal Surgery: A Protocol for a Scoping Review

BACKGROUND: Perioperative hypotension in patients undergoing gastrointestinal surgery is a known and well-described condition. Timely treatment of perioperative hypotension, regardless of the reason, is important in order to reduce the associated postoperative complications. The...

Arrest of human spermatogenesis at the pachytene stage is frequently accompanied by disruption of the piRNA pathway

Abstract Recent genetic studies have identified defects in the PIWI-interacting RNA (piRNA) pathway to cause nonobstructive azoospermia. However, limited knowledge of piRNA function in human spermatogenesis makes it difficult to quantify the number of cases affected. Central to t...

Factors Associated with Persistently Increased IL-6 Levels in People with HIV

BACKGROUND: Individuals with HIV remain at higher risk of non-communicable diseases associated with interleukin-6-specific (IL-6) inflammation compared to the background population. Despite antiretroviral therapy, some individuals exhibit persistent hyperinflammation. We characte...

Regional Variation in ADHD Treatment and Diagnosis Among Children and Adolescents in Denmark

ABSTRACT Geographic variation in ADHD treatment and diagnosis among children and adolescents is well documented, yet the system‐level factors driving such differences remain poorly understood. We examined nationwide patterns of ADHD medication use and diagnoses in Denmark in 2024...

Durability of RSV Prefusion F Vaccine Protection across Two RSV Seasons

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death among older adults. Although first-season vaccine effectiveness against RSV-related hospitalization has been demonstrated for the bivalent RSV prefusion F protein-based vaccine (RSVpr...

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

Clinical relevance of pharmacogenomic information for improving prescribing practices in acutely admitted older medical patients

AIMS: Safe prescribing and effective medication review during acute hospitalization depends on accurate information about liver and kidney function because these organs are responsible for the elimination of most medications. While estimates for kidney function are widely used, c...

The historical development of sample size estimation: from Huygens and Bernoulli to the present

This paper traces the historical development of frequentist sample size estimation from its philosophical origins to its present-day complexity. Preliminary concepts were identified by Christiaan Huygens’ work on expected value and Jacob Bernoulli’s law of large numbers , which f...

Variation in meningioma recurrence risk estimates across observational cohorts: the influence of calendar time, WHO classifications, geographical settings, and healthcare systems

Abstract Purpose Recurrence risk estimates underpin meningioma research, including molecular classification and clinical trial benchmarking, yet are often based on retrospective or historical data. The aim of this study was to assess the variation of recurrence risk estimates acr...

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis

BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...

Longitudinal Immunophenotypic Changes in Refractory Lupus Nephritis After B-cell Depletion: A 25-year Case Study

Background/Aim: Long-term management of systemic lupus erythematosus (SLE) requires a persistent balance between intensive immunosuppression and the prevention of opportunistic infections. This is particularly challenging in patients with a multi-decade disease history and evolvi...

Lessons from the Danish Vascular (DanVasc) pilot survey: patient-reported outcomes following lower extremity, carotid and aortic artery disease

Patient-reported outcomes are insufficiently studied across the three predominant vascular diseases: lower extremity artery disease (LEAD), symptomatic carotid stenosis (SCS) and abdominal aortic aneurysm (AAA). To address this gap, the Danish Vascular (DanVasc) survey was develo...

Uncovering dynamic human brain phase coherence networks

Abstract Complex cognitive functions rely on coordinated communication between distributed brain regions, yet capturing these interactions as they evolve over time remains challenging. Traditional analyses of functional brain connectivity largely rely on correlations in signal am...

Evaluation of a human slow-release buprenorphine formulation in rats – tactile sensitivity and plasma concentration

Abstract Background Opioids are considered ideal for managing moderate to severe post-operative pain in laboratory rodents, with buprenorphine being one of the most commonly used analgesics in rats. A long-acting buprenorphine formulation would be highly beneficial to avoid frequ...

Low‐Dose Fisetin Supplementation and Its Association With Chronic Inflammation in Middle‐Aged and Older Adults: Study Protocol for a Triple‐Blind, Randomised, Placebo‐Controlled Trial

ABSTRACT Systemic chronic inflammation contributes to the development of many age‐related chronic diseases and represents a promising target for interventions aiming at promoting healthy aging. Fisetin is a naturally occurring flavonoid with anti‐inflammatory, antioxidant and sen...

Patient preferences for the multidisciplinary management of endometriosis and adenomyosis: a mixed-methods survey-based study

Background: Endometriosis and adenomyosis are common, debilitating conditions frequently associated with delayed diagnosis and fragmented care-based pathways. In Denmark, two highly specialized centres provide advanced endometriosis treatment. However, it remains unclear whether...

Internet-based Emotion Regulation Individual Therapy for Adolescents (IERITA) plus treatment as usual versus treatment as usual for adolescent outpatients with non-suicidal self-injury—the TEENS multi-site trial: study protocol and statistical analysis plan for a multi-site randomised clinical trial

Non-suicidal self-injury (NSSI) is a public health concern and a widespread behaviour, especially among adolescents. NSSI is an indicator of psychological distress and a known risk factor for later suicidal behaviour and death by suicide; however, evidence-based treatment options...

OA03-RF01.05. The Safety and Efficacy of Endoscopic Submucosal Dissection for Early Esophageal Squamous Cell Carcinoma in Scandinavia (SEES-Study)

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer – early outcomes and complications Background Endoscopic submucosal dissection (ESD) is recommended for early-stage esophageal squamous cell carcinoma (ESCC). Most data on the efficacy of ESD for ESCC comes...

P1.158. Clinical Performance of a Liquid Fiducial Marker for Preoperative Marking of the Optimal Resection Line in Gastroesophageal Cancer Surgery

Abstract Topic Esophageal Cancer: Surgical Treatment of Esophageal Cancer Background Esophageal and gastroesophageal junction cancers have a poor prognosis despite improvements in curative treatment. Achieving microscopically cancer-free resection margins is essential for long-te...

Effect of thermal ablation on persistent HPV infection in Danish women ≥ 40 years of age: a quasi-randomized clinical study

Thermal ablation is a cervical heat treatment that destroys a defined area of the cervix. We evaluated whether thermal ablation facilitates HPV clearance in women with persistent high-risk human papillomavirus (HR-HPV) infection, using HPV status and FAM19A4/miR124-2 DNA methylat...