Copenhagen University Hospital

Sexual and relational challenges in men and women affected by prostate cancer: a Project SEXUS study

OBJECTIVES: To examine, in a nationally representative Danish study, a comprehensive range of sexual characteristics, dysfunctions and relational challenges among men with prostate cancer (PCa) aged ≥50 years and women married to such men, compared with unaffected men and women....

Evidence-based atlas of risk and protective factors for psychotic disorders: an umbrella review to inform personalized prognosis and prevention.

Identifying updated, evidence-based risk and protective factors for psychotic disorders is essential to advancing scientific and clinical knowledge of their etiology. Since the most recent umbrella review published in this journal, the evidence base has expanded substantially. Fo...

A Systematic Review and Meta-Analysis of the Prognostic Value of Tumor Response Measurements During Radiotherapy for Head and Neck cancers.

AIMS: This review evaluates the literature on the prognostic value of in-treatment tumor response measurements during radiotherapy for head and neck cancer, assessing the most commonly used imaging modalities through meta-analysis. MATERIALS AND METHODS: A systematic literature s...

A phosphoproteome atlas of human cell lines reveals the landscape of kinase activity

Abstract Protein phosphorylation orchestrates cellular signaling and controls most biological processes, with its dysregulation driving diseases, notably cancer. Comprehensive, high-throughput phosphoproteomics remains limited by detection sensitivity, data completeness and compu...

Exploring the Feasibility and Acceptability of Compassion and Mindfulness Training for Adolescents With Type 1 Diabetes and Their Caregivers

AIM: To examine the feasibility and acceptability of mindfulness training for adolescents with Type 1 diabetes (T1D) and compassion training for caregivers. METHODS: Adolescents aged 12-17 years with T1D, and their caregivers were recruited from two diabetes centres between 2022...

Validation of Parent‐Report Questionnaires for Large‐Scale Online Screening of Avoidant/Restrictive Food Intake Disorder in Children and Adolescents

ABSTRACT Objective Studies assessing the validity of screening measures for avoidant/restrictive food intake disorder (ARFID) remain scarce. We evaluated the diagnostic performance and validity of an online, parent‐reported screening approach for ARFID in a population‐based sampl...

Glutamate levels in antipsychotic-free, first-episode psychosis: a 7-tesla MRS study across five brain regions

Disrupted glutamatergic signaling across cortical and subcortical circuits is increasingly recognized as a critical player in the pathophysiology of psychosis. Using ultra-high-field (7 Tesla) proton MRS, we quantified glutamate levels across five brain regions in antipsychotic-f...

Major adverse cardiac events and mortality associated with ADHD and its treatment in adults with type 2 diabetes: a multi-national cohort study

Abstract Background Attention-deficit/hyperactivity disorder (ADHD) has been linked to elevated risk of type 2 diabetes (T2D). However, the impact of ADHD and ADHD medication use on prognosis and health outcomes in T2D remains unclear. This study investigates the associations of...

Short‐Term Clinical Outcomes and Complication Timing in Patients With Postoperative Delirium After Major Emergency Abdominal Surgery: A Prospective Cohort Study

ABSTRACT Background Postoperative delirium is linked to increased morbidity, mortality, and prolonged hospitalization; however, its short‐term consequences after major emergency abdominal surgery remain insufficiently studied. Methods This prospective cohort study included 752 pa...

Long-term Mortality and Shock-rate in Patients Surviving Out-of-Hospital Cardiac Arrest with and without early implantation of an Implantable Cardioverter Defibrillator

Introduction In patients who survive out-of-hospital cardiac arrest (OHCA), guidelines for implantation of an implantable cardioverter-defibrillator (ICD) are not unequivocal.Methods Patients resuscitated from OHCA of cardiac cause, without a reversible cause and an expected surv...

Operationalizing fear of cancer recurrence care: a modified Delphi study establishing a consensus-based clinical pathway for Danish cancer survivors

BACKGROUND AND PURPOSE: Fear of cancer recurrence (FCR) is a prevalent concern among cancer survivors. Although evidence-based FCR guidelines exist, their implementation requires further operationalization. This study aimed to establish expert consensus on a clinical pathway to o...

Variation in assessment of dissection plane after transanal total mesorectal excision (TaTME) among experienced colorectal pathologists

Abstract Purpose Evaluation of the dissection plane is an important measure of surgical quality in relation to rectal cancer. Although well-defined criteria exist assessments may vary. The aim of this study was to assess variation in the evaluation of dissection plane of transana...

Use of Ibuprofen Before and in Early Pregnancy Among Women With and Without Chronic Medical Diseases. A Cross‐Sectional Study

PURPOSE: While having a chronic medical disease (CMD) increases use of analgesics and anti-inflammatory drugs, sufficient knowledge regarding patterns of use during pregnancy is lacking. We aimed to describe ibuprofen use before and in early pregnancy among women with and without...

Clinical outcomes and diagnostic stability in first-episode other specified schizophrenia spectrum and other psychotic disorder: evidence for a distinct clinical entity

Research on the clinical outcomes and diagnostic stability of first-episode other specified schizophrenia spectrum and other psychotic disorder (FE-OSSO) remains very limited. This study was conducted to identify baseline demographic and clinical features and cognitive function,...

An international position statement on practical approaches for inpatient continuous glucose monitoring, insulin pumps and automated insulin delivery systems in adults

There is an urgent and unmet need for a practical clinical guideline addressing the use of continuous glucose monitoring (CGM), insulin pumps and automated insulin delivery (AID) systems in hospital settings. The goal with this position statement is to facilitate effective and sa...

Childhood body mass index trajectories and subtypes of endometrial cancer: A Danish cohort study

Background Obesity in adulthood is a well-established risk factor for endometrial cancer, a heterogeneous disease comprising several histological subtypes. Although childhood body mass index (BMI) is linked to endometrial cancer, the role of childhood growth patterns in different...

Household consumer purchases and chronic disease

Chronic disease risk stratification remains costly and often provides limited insight into modifiable exposures. Consumer purchases are routinely generated, low-burden measures of household lifestyle that can be linked to health outcomes with consent. In this Danish cohort study,...

Assisted cycling in non-ambulant adults with cerebral palsy: exploratory effects and feasibility in residential care

OBJECTIVE: Adults with cerebral palsy (Gross Motor Function Classification System, GMFCS, levels III-V) have severely impaired motor function, causing fatigue, pain, constipation, and sleep disturbance, reducing life quality. Whether standard exercise is feasible or beneficial in...

Oral vitamin C supplementation in patients with clonal cytopenia of undetermined significance or lower‐risk myeloid malignancies: Results from EVITA, a phase 2 randomized, placebo‐controlled trial

BACKGROUND: Vitamin C (VitC) is a cofactor for TET enzymes involved in DNA demethylation and epigenetic regulation. Mutations in TET2 are common drivers of leukemia. Preclinical studies suggest that VitC may delay leukemia progression. This study aimed to evaluate the biological...

Scalable clinical proteomics from DNA/RNA extraction flowthroughs enables integrated proteogenomic profiling from a single cancer biopsy

Abstract Background Precision oncology has largely relied on genomic and transcriptomic sequencing to guide therapy selection in patients with advanced cancer. However, these molecular layers do not fully capture the functional state of tumors, as proteins largely represent the a...